Coxsackie B2 Virus Infection Causing Multiorgan Failure and Cardiogenic Shock in a 42-Year-Old Man

Hopkins, Kali A.; Abdou, Mahmoud H.; Hadi, M. Azam

doi:10.14503/thij-17-6361

Cited by 12 publications

(14 citation statements)

References 17 publications

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“…CVB infections are found worldwide, and they primarily occur in children and young adults. The course of myocarditis differs between individuals, with outcomes including complete recovery and disease resolution, cardiogenic shock, atrioventricular fibrillations and sudden cardiac arrest, the development of autoimmune myocarditis, and the onset of dilated cardiomyopathy [6,31,32]. The reason for such variation in outcomes is still not fully understood.…”

Section: Enterovirusesmentioning

confidence: 99%

Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure

Martens

Accornero

2021

Viruses

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Viruses are an underappreciated cause of heart failure. Indeed, several types of viral infections carry cardiovascular risks. Understanding shared and unique mechanisms by which each virus compromises heart function is critical to inform on therapeutic interventions. This review describes how the key viruses known to lead to cardiac dysfunction operate. Both direct host-damaging mechanisms and indirect actions on the immune systems are discussed. As viral myocarditis is a key pathologic driver of heart failure in infected individuals, this review also highlights the role of cytokine storms and inflammation in virus-induced cardiomyopathy.

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Section: Enterovirusesmentioning

confidence: 99%

Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure

Martens

Accornero

2021

Viruses

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“…In addition, presence of slow-growing or intracellular microorganisms like Bartonella quintana, Staphylococcus aureus, Streptococcus equi, and Streptococcus oralis may also cause BCNE [4,5]. Helicobacter pylori, Mycoplasma pneumonia, Bacillus typhosus and Chlamydia pneumonia, and viral pathogens including fowl adenovirus serotype 4 (FAdV-4), parvovirus B19, Hepatitis C Virus (HCV), Enterovirus (Coxsackie Virus), thecytomegalovirus and herpes simplex viruses have long been known to cause coronary artery disease, myocarditis and pericarditis [6][7][8][9]. Myocarditis caused by Staphylococcus aureus often results into sepsis (bacteria growing in the blood) and may form abscesses in the heart [6].…”

Section: Important Microorganisms Causing Cardiovascular Diseasesmentioning

confidence: 99%

Microorganisms and cardiovascular diseases: importance of gut bacteria

Noor

Naz

Maniha

et al. 2021

Front. Biosci. (Landmark Ed)

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Introduction 3. Important microorganisms causing cardiovascular diseases 3.1 CVD causing pathogens 4. The gut microbiome and the protective immunity 4.1 Gut microbiome and CVD 4.2 How the gut microbiome triggers CVD? 4.3 Gut microorganisms, adaptive immunity, autoimmunity, and CVD 5. Conclusions 6. Author contributions 7. Ethics approval and consent to participate 8. Acknowledgment 9. Funding 10. Conflict of interest 11. References

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“…The usefulness of ECMO in patients with acute or fulminant viral myocarditis with hemodynamic instability has been reported in infections caused by enterovirus and Coxsackie virus [11,12]. However, there are no reports showing that ECMO support is successful in treating myocarditis secondary to SFTS.…”

Section: Electrocardiography (Ecg) At Presentation Ecg Showing a Normal Sinus Rhythm On Day 1 A Chest X-ray On Day 1 Is Also Shown (Panelmentioning

confidence: 99%

Veno-arterial extracorporeal membrane oxygenation for severe fever with thrombocytopenia syndrome with fulminant myocarditis: a case report

et al. 2021

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Background The clinical spectrum of severe fever with thrombocytopenia syndrome (SFTS) is wide, which can range from fever to multiple organ failure. Conservative therapy plays a key role in the treatment of SFTS. However, severe cases of SFTS, such as fulminant myocarditis, may require mechanical hemodynamic support. Case presentation This report presents a case of a 59-year old woman diagnosed with SFTS by reverse-transcription polymerase chain reaction. The patient had no initial symptoms of cardiac involvement and rapidly developed hemodynamic instability 3 days after hospitalization. She suffered from chest pain and had elevated cardiac enzymes. In the absence of atrio-ventricular conduction abnormalities, left ventricular dysfunction, and coronary artery abnormalities by coronary angiography, she was diagnosed with fulminant myocarditis. At that time, her pulse rate nearly dropped to 0 bpm and she developed near complete akinesia of the heart despite vasopressor administration. Veno-arterial extracorporeal membrane oxygenation (ECMO) was initiated with other supportive measures and she fully recovered after 21 days. Conclusions This case indicates that SFTS can cause fulminant myocarditis even without evidence of cardiac involvement at presentation. When symptoms and/or signs of acute heart failure develop in patients with SFTS, myocarditis should be suspected and the patient should be promptly evaluated. Additionally, mechanical hemodynamic support like ECMO can be a lifesaving tool in the treatment of fulminant myocarditis.

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Coxsackie B2 Virus Infection Causing Multiorgan Failure and Cardiogenic Shock in a 42-Year-Old Man

Cited by 12 publications

References 17 publications

Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure

Viruses in the Heart: Direct and Indirect Routes to Myocarditis and Heart Failure

Microorganisms and cardiovascular diseases: importance of gut bacteria

Veno-arterial extracorporeal membrane oxygenation for severe fever with thrombocytopenia syndrome with fulminant myocarditis: a case report

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