CpG oligodeoxynucleotide-specific duck TLR21 mediates activation of NF-κB signaling pathway and plays an important role in the host defence of DPV infection

Cheng, Da Long; Wu, Xuedong; Jia, Renyong; Wang, Mingshu; Chen, Shun; Liu, Mafeng; Zhu, Dekang; Zhao, Xinxin; Wu, Ying; Yang, Qiao; Zhang, Shaqiu; Zhang, Ling; Liu, Yunya; Yin, Zhongqiong; Jing, Bo; Cheng, Anchun

doi:10.1016/j.molimm.2018.12.019

Cited by 10 publications

(5 citation statements)

References 43 publications

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“…TLR15 is upregulated in response to bacterial pathogens in chickens (Nerren et al, 2010), and recognizes a yeast-derived agonist (Boyd et al, 2012) and diacylated lipopeptide from mycoplasma (Oven et al, 2013). TLR21 functions analogously to TLR9 in humans in that it recognizes CpG oligodeoxynucleotides (CpG ODN) in both duck (Cheng D. et al, 2019) and chicken (Brownlie et al, 2009).…”

Section: Toll-like Receptor Pathwaymentioning

confidence: 99%

Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens

Campbell

Magor

2020

Front. Cell. Infect. Microbiol.

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Mallard ducks are a natural host and reservoir of avian Influenza A viruses. While most influenza strains can replicate in mallards, the virus typically does not cause substantial disease in this host. Mallards are often resistant to disease caused by highly pathogenic avian influenza viruses, while the same strains can cause severe infection in humans, chickens, and even other species of ducks, resulting in systemic spread of the virus and even death. The differences in influenza detection and antiviral effectors responsible for limiting damage in the mallards are largely unknown. Domestic mallards have an early and robust innate response to infection that seems to limit replication and clear highly pathogenic strains. The regulation and timing of the response to influenza also seems to circumvent damage done by a prolonged or dysregulated immune response. Rapid initiation of innate immune responses depends on viral recognition by pattern recognition receptors (PRRs) expressed in tissues where the virus replicates. RIG-like receptors (RLRs), Toll-like receptors (TLRs), and Nod-like receptors (NLRs) are all important influenza sensors in mammals during infection. Ducks utilize many of the same PRRs to detect influenza, namely RIG-I, TLR7, and TLR3 and their downstream adaptors. Ducks also express many of the same signal transduction proteins including TBK1, TRIF, and TRAF3. Some antiviral effectors expressed downstream of these signaling pathways inhibit influenza replication in ducks. In this review, we summarize the recent advances in our understanding of influenza recognition and response through duck PRRs and their adaptors. We compare basal tissue expression and regulation of these signaling components in birds, to better understand what contributes to influenza resistance in the duck.

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Section: Toll-like Receptor Pathwaymentioning

confidence: 99%

Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens

Campbell

Magor

2020

Front. Cell. Infect. Microbiol.

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“…TLR21 also has a role in duck immune response against DNA and DNA viruses. Stimulation of DEFs transfected with duTLR21 with CpG-ODN activated NF-κB, followed by the increased expression of the IFN-α, IL-6, and IL-1β mRNA, whereas knockdown of duTLR21 impaired the expression of these genes (Cheng et al, 2019;Chuang et al, 2020). Furthermore, an in vitro study has indicated that ectopic expression of duTLR21 blocks the duck plague virus (DPV) replication, while knockdown of duTLR21 efficiently facilitates DPV replication (Cheng et al, 2019).…”

Section: Chtlr21mentioning

confidence: 99%

The Evasion of Antiviral Innate Immunity by Chicken DNA Viruses

2021

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The innate immune system constitutes the first line of host defense. Viruses have evolved multiple mechanisms to escape host immune surveillance, which has been explored extensively for human DNA viruses. There is growing evidence showing the interaction between avian DNA viruses and the host innate immune system. In this review, we will survey the present knowledge of chicken DNA viruses, then describe the functions of DNA sensors in avian innate immunity, and finally discuss recent progresses in chicken DNA virus evasion from host innate immune responses.

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“…Cloning and characterization of Cherry valley duck TLR21 (duTLR21) indicated that it shares 92% identity with goose TLR21 (goTLR21) and 76% identity with chTLR21 with 20 LRR motifs; a signal peptide; a TM domain; and an intracellular TIR domain comprising box 1, box 2, and box 3, three conserved motifs [86]. Like chTLR21, duTLR21 exhibited broader ligand specificity and responded to CpG-ODN through NFκB activation and downstream transcription of IL-1β, IL-6, and IFN-α [86]. Lastly, ectopic expression of duTLR21 in DEF cells conferred an antiviral effect against duck plague virus (DPV) infection [86].…”

Section: Tlr21mentioning

confidence: 99%

“…Like chTLR21, duTLR21 exhibited broader ligand specificity and responded to CpG-ODN through NFκB activation and downstream transcription of IL-1β, IL-6, and IFN-α [86]. Lastly, ectopic expression of duTLR21 in DEF cells conferred an antiviral effect against duck plague virus (DPV) infection [86].…”

Section: Tlr21mentioning

confidence: 99%

Avian Pattern Recognition Receptor Sensing and Signaling

Neerukonda

Katneni

2020

Veterinary Sciences

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Pattern recognition receptors (PRRs) are a class of immune sensors that play a critical role in detecting and responding to several conserved patterns of microorganisms. As such, they play a major role in the maintenance of immune homeostasis and anti-microbial defense. Fundamental knowledge pertaining to the discovery of PRR functions and their ligands continue to advance the understanding of immune system and disease resistance, which led to the rational design and/or application of various PRR ligands as vaccine adjuvants. In addition, the conserved nature of many PRRs throughout the animal kingdom has enabled the utilization of the comparative genomics approach in PRR identification and the study of evolution, structural features, and functions in many animal species including avian. In the present review, we focused on PRR sensing and signaling functions in the avian species, domestic chicken, mallard, and domestic goose. In addition to summarizing recent advances in the understanding of avian PRR functions, the present review utilized a comparative biology approach to identify additional PRRs, whose functions have been well studied in mammalians but await functional characterization in avian.

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CpG oligodeoxynucleotide-specific duck TLR21 mediates activation of NF-κB signaling pathway and plays an important role in the host defence of DPV infection

Cited by 10 publications

References 43 publications

Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens

Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens

The Evasion of Antiviral Innate Immunity by Chicken DNA Viruses

Avian Pattern Recognition Receptor Sensing and Signaling

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