CpG oligodeoxynucleotide synergizes innate defense regulator peptide for enhancing the systemic and mucosal immune responses to pseudorabies attenuated virus vaccine in piglets in vivo

Cao, Ding; Li, Huazhou; Jiang, Zhenggu; Cheng, Qing; Yang, Zhaihan; Xu, Chenchao; Cao, Guangjun; Zhang, Linghua

doi:10.1016/j.intimp.2011.01.028

Cited by 18 publications

(9 citation statements)

References 34 publications

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“…The beneficial use of IDR peptides for the control of infections is now well established in preclinical models of a wide range of pathogens, including multidrug resistant bacteria, viruses, parasites, and antibiotic-recalcitrant bacterial biofilms 54,[56][57][58][59][60] . IDR peptides also exhibit adjuvant functions to enhance mucosal immunity and antigen-specific humoral response [61][62][63][64] , and are effective in controlling inflammation and related physiological outcomes in models of sterile inflammation 65 and chronic inflammatory diseases 21 . A distinct advantage of IDR peptide-based therapy, compared to current anti-inflammatory therapeutics, is the potential to resolve infections along with the ability to control inflammation 54,57 .…”

Section: [H2] Synthetic Innate Defence Regulator (Idr) Peptidesmentioning

confidence: 99%

Antimicrobial host defence peptides: functions and clinical potential

Mookherjee

Anderson

Haagsman

et al. 2020

Nat Rev Drug Discov

976

955

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Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally-occurring peptides which can combat infections through their direct microbicidal properties and/or by influencing the host's immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been employed to design synthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies. This has led to the adoption of the current name for this family of peptides, Cationic Host Defence Peptides, which encompasses the wide range of described functions. Over the last three decades there has been substantial interest in therapeutically harnessing CHDP, with more than 5000 papers published in this area of research since 2017 alone. These include the examination of potential clinical uses for CHDP ranging from infections including multidrug-resistant bacteria 16-19 , to chronic inflammatory diseases such as arthritis 20 , asthma 21 and colitis 22 , as well as some cancers 23. Peptide-based therapeutics currently in clinical trials are primarily for the treatment of infections such as respiratory, oral and catheter-related infections, and for wound healing (see http://dramp.cpu-bioinfor.org/browse/ClinicalTrialsData.php). This review will provide an overview of current understanding of the scope of functions of CHDP, primarily from eukaryotes. Emerging therapeutic applications of these peptides, current clinical trials and the associated clinical developmental challenges will be discussed. Although there is increasing interest in the development of non-peptide mimics of CHDP for therapeutic application, such as peptoid analogs (reviewed in 24), a comprehensive discussion of these approaches is beyond the scope of this review. [H1] Naturally occurring CHDP The antimicrobial peptide database has catalogued more than 2600 natural antimicrobial peptides, including those annotated as immunomodulatory 25. The major families of CHDP from eukaryotes that are of interest from a drug discovery perspective are summarized below. [H2] Vertebrate CHDP CHDP from vertebrates have an essential role in the first line of defense against microbial pathogens. Upon infection, CHDP can kill pathogens through diverse mechanisms 26-31 (discussed below), acting rapidly and directly on the pathogen when present in high local concentrations, or indirectly to modify components of host defense. These peptides exhibit immunomodulatory activities that can be either pro-or anti-inflammatory depending on the phase of the infection (see below) 12-14,29. CHDP from vertebrates are amphipathic peptides containing amino acids with hydrophilic and hydrophobic side chains at opposite sides of the molec...

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Section: [H2] Synthetic Innate Defence Regulator (Idr) Peptidesmentioning

confidence: 99%

Antimicrobial host defence peptides: functions and clinical potential

Mookherjee

Anderson

Haagsman

et al. 2020

Nat Rev Drug Discov

976

955

View full text Add to dashboard Cite

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“…A recent study has also demonstrated that oral administration of the cathelicidin peptide LL-37 elicits T-cell dependent antigen-specific antibody mucosal responses primarily via a Th17-skewed pathway, by interacting with receptors on M cells [ 79 ]. Studies effectively using synthetic derivatives of CHDPs as adjuvants in vaccine formulations have corroborated the role of these peptides in the adaptive immune response [ 80 , 81 , 82 ]. Taken together, these studies indicate that CHDPs function at the interface of innate and adaptive immune responses and play a critical role in promoting initiation, polarization and amplification of adaptive immunity.…”

Section: Chdps Bridge Innate and Adaptive Immunitymentioning

confidence: 99%

Functions of Cationic Host Defense Peptides in Immunity

2016

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Cationic host defense peptides are a widely distributed family of immunomodulatory molecules with antimicrobial properties. The biological functions of these peptides include the ability to influence innate and adaptive immunity for efficient resolution of infections and simultaneous modulation of inflammatory responses. This unique dual bioactivity of controlling infections and inflammation has gained substantial attention in the last three decades and consequent interest in the development of these peptide mimics as immunomodulatory therapeutic candidates. In this review, we summarize the current literature on the wide range of functions of cationic host defense peptides in the context of the mammalian immune system.

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“…An innate defence regulator peptide, HH2, has shown synergy with oligonucleotides containing CpG motifs, when used as an immunoadjuvant to enhance the immune response through stimulation of T-helper 1 and T-helper 2 responses in newborn piglets which were vaccinated with a pseudorabies attenuated virus vaccine [29]. Recently, Brown et.…”

Section: Commercial Potential Of Milk Derived Proteins and Peptidesmentioning

confidence: 99%

“…It is tremendously encouraging that many of these proteins and peptides have pharmaceutical potential within antiviral and anticancer therapy, as vaccine adjuvants, as immunosuppressants for the treatment of autoimmune diseases and in conjunction with organ transplantation, etc. [20,[23][24][25][27][28][29].…”

Section: Introductionmentioning

confidence: 99%