CPPD crystal deposition disease of the cervical spine: A common cause of acute neck pain encountered in the neurology department

Abstract

Background: Calcium pyrophosphate dehydrate (CPPD) crystal deposition disease is one of

Headache in a Patient With Crowned Dens: Report of a New Case

“…His employer, the University Hospital Basel, has received compensation for his serving on scientific advisory boards or speaking fees from Novartis,ATI, Genzyme,Actelion, Jansen,Teva, Mitsubishi Pharma Europe, and Biogen Idec.These fees were used for funding of research. Patients affected by CDS usually suffer from periodic attacks of non-lateralized cervico-occipital pain, 11 while this patient had strictly left-sided headaches with the peak in the frontal area. He has consulted for Pfizer, Nevrocorp, Lundbeck, Zogenix, Impax, Zosano, and Dr. Reddy, and has been compensated for expert legal testimony.…”

“…The second atypical feature related to the localization of the pain. Patients affected by CDS usually suffer from periodic attacks of non-lateralized cervico-occipital pain, 11 while this patient had strictly left-sided headaches with the peak in the frontal area. The CT and MRI scans accordingly showed a mainly left-sided posterolateral degenerative process around the periodontoid articular structures with contact to the left C2 root and left vertebral artery (see Fig.…”

Frequency of Atlantoaxial Calcium Pyrophosphate Dihydrate Deposition at CT

“…In addition, although CT is generally regarded as sensitive for the detection of small calcifications, it is certainly less sensitive than histologic examination (17), which may result in underestimation of the true prevalence. Furthermore, not all CT-evident calcifications relate to CPPD crystal deposition at histologic examination, although histologic analysis is generally not performed in the clinical setting and characteristic calcifications are generally assumed to be due to CPPD crystal deposition (22,28). With regard to retro-odontoid soft-tissue thickness, we did not evaluate any potential causes other than CPPD crystal deposition that could be diagnosed at imaging, such as osteoarthrosis or an inflammatory arthropathy.…”

Incidence, Age and Gender of Subjects With the Calcium Pyrophosphate Deposition Around the Dens, and Clinical Characteristics of Patients With Crowned Dens Syndrome

“…CDS has been reported to be misdiagnosed and under-recognized as a cause of acute neck pain and fever of unknown origin [25,26]. Clinical, biochemical and radiological characteristics for CDS obtained from our study may The calcification around the dens detected by CT…”