2005
DOI: 10.1210/me.2004-0107
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CR6-Interacting Factor 1 Interacts with Orphan Nuclear Receptor Nur77 and Inhibits Its Transactivation

Abstract: CR6-interacting factor 1 (CRIF1) was recently identified as a nuclear protein that interacts with the Gadd45 (growth arrest and DNA damage inducible 45) family of proteins and participates in the regulation of the G1/S phase of the cell cycle. However, the nuclear action of CRIF1 is largely unknown. In this study, we demonstrate that CRIF1 acts as a novel coregulator of transactivation of the orphan nuclear receptor Nur77. Both in vitro and in vivo studies show that CRIF1 interacts with Nur77 via the Nur77 AB … Show more

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Cited by 42 publications
(36 citation statements)
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“…Besides STAT3, Crif1 has other binding partners, such as all three members, Gadd45a, Gadd45b, and Gadd45g, of the Gadd45 protein family and Nur77 (Chung et al, 2003;Park et al, 2005). Although the early embryonic lethality of the Crif1 À/À mice cannot be explained by the interactions with the Gadd45 family members and Nur77, because their mutant mice are viable and fertile, the more severe phenotypes of Crif1 À/À embryos might be due to the additional dysfunctions of other binding partners, in the absence of STAT3 signalling (Lee et al, 1995;Hollander et al, 1999;Gupta et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Besides STAT3, Crif1 has other binding partners, such as all three members, Gadd45a, Gadd45b, and Gadd45g, of the Gadd45 protein family and Nur77 (Chung et al, 2003;Park et al, 2005). Although the early embryonic lethality of the Crif1 À/À mice cannot be explained by the interactions with the Gadd45 family members and Nur77, because their mutant mice are viable and fertile, the more severe phenotypes of Crif1 À/À embryos might be due to the additional dysfunctions of other binding partners, in the absence of STAT3 signalling (Lee et al, 1995;Hollander et al, 1999;Gupta et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Crif1 interacts with Gadd45a,b,g, and Nur77, and has been suggested as a potential regulator of cell cycle progression and cell growth (Chung et al, 2003;Park et al, 2005). To determine the role of Crif1 in vivo, we generated mice with a disruption in the gene encoding Crif1.…”
Section: Introductionmentioning
confidence: 99%
“…This in turn down-regulates Gadd45 proteins (28 -30). Gadd45 interacts with Gadd45GIP1 and up-regulates MKK4 through MEKK4/MTK1 activation (31). In this manner, Gadd45 functions as a tumor suppressor (26).…”
Section: Discussionmentioning
confidence: 99%
“…Gadd45GIP1 co-localized with Gadd45g in the nuclei, and recombinant Gadd45GIP1 proteins inhibited histone H1 kinase activity of immunoprecipitated Cdc2/ cyclin B1 and Cdk2/cyclin E. The inhibitory effects were synergistic by Gadd45 proteins. In addition, Gadd45GIP1 interacts with the Orphan nuclear receptor, Nur77, and inhibits its transactivation (28). Biologically, overexpression of Gadd45GIP1 inhibited cellular proliferation in NIH3T3 cells, and Gadd45GIP1 gene knockdown led to the inactivation of the Rb pathway (17).…”
Section: Discussionmentioning
confidence: 99%