Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats

An, Yeon Ju; Kim, Yulha; Jun, Woojin; Lee, Yoo‐Hyun

doi:10.1089/jmf.2020.4779

Cited by 6 publications

(4 citation statements)

References 38 publications

(37 reference statements)

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“…Due to these reasons, many studies have tested the inhibitory effects of many compounds, especially phytochemicals, on the development of BPH by measuring prostate weights. 36 In the present study also, oral administration of ethanolic (A) and hydroxyalcoholic (B) extracts of C. bonduc seed, at 400 mg/kg, resulted in substantial reductions in absolute and relative prostate weights. Hence, the ability of C. bonduc seed extracts to reduce the prostate weight of BPH-induced rats clearly pointed the ameliorative potential of this plant.…”

Section: Discussionsupporting

confidence: 62%

Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats

Sasidharan¹,

KP²,

Bhaumik³

et al. 2022

RRU

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Introduction Benign prostatic hyperplasia (BPH) is a major chronic disease affecting men, and the therapeutic agents currently used to manage it have significant side effects. As a result, an alternative medicine with improved therapeutic properties with no side effects is desperately needed. The current investigation aims to study whether the Caesalpinia bonduc seed extracts (ethanolic-A, hydroalcoholic-B, and aqueous-C) have inhibitory potential on testosterone propionate (TP)-induced BPH in Wistar rats. Methods Wistar rats (male) were randomly allocated to one of five groups: control, BPH (TP-3 mg/kg, subcutaneously daily), low dose (TP + C. bonduc seed extracts – 200 mg/kg body weight), high dose (TP + C. bonduc seed extracts – 400 mg/kg body weight), and standard drug (TP + finasteride – 10 mg/kg body weight). At the end of drug treatment, the rats were sacrificed and their serum and prostates were taken for biochemical and histological studies. Results C. bonduc seed extracts treatment significantly decreased prostate weight and prostatic index in rats with TP-induced BPH. The seed extracts exhibited a potent inhibitory effect on dihydrotestosterone (DHT) in serum and prostate. In addition, the PSA level in the serum showed a noteworthy decrease in comparison with the BPH group. Histopathological examination also indicated that extracts improved the tissue morphology of the prostate significantly. Out of three extracts tested, ethanolic and hydroalcoholic extract recorded significant effect. Finally, liquid chromatography quadrupole time-of-flight mass spectrometry (LC/MS-QTOF) analysis showed that the major compounds present in the extracts were tocopherols, fucosterol, linoleic acid, β-amyrin, β-sitosterol, campesterol, cassane furanoditerpene, norcassane furanoditerpene and other diterpenes. Conclusion Thus, C. bonduc seed extracts could be a potential source for the formulation of new drug for managing BPH. To the best of our knowledge, this is the first scientific animal investigation into the use of C. bonduc seed extract for the management of BPH.

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Section: Discussionsupporting

confidence: 62%

Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats

Sasidharan¹,

KP²,

Bhaumik³

et al. 2022

RRU

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“…Prostate enlargement and increasing its weight is considered as a vital marker for detecting and evaluating BPH. In our results, TP given group significantly increased prostate weight and these results are in line with previous studies [7,18,19] . However, DIA plus BPH could significantly diminish prostate weight indicating the improvement of BPH.…”

Section: Discussionsupporting

confidence: 93%

Diacerein ameliorates benign prostatic hyperplasia with dysplastic changes in rats via modulation of IL1β and Nrf2/HO1 pathway

Refaie

Bayoumi

El-Hussieny

2021

Minia Journal of Medical Research

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Benign prostatic hyperplasia (BPH) is a common disrupting health problem affects elderly men. However, different mechanisms underlying the pathogenesis of BPH are still unclear. For the first time, we tried to explore the role of interleukin 1β (IL1β) antagonist, diacerein (DIA) in BPH and different pathways involved in mediating such effect. BPH was induced using testosterone propionate (TP) (5 mg/kg/day) for 4 weeks subcutaneous injection followed by DIA (50 mg/kg/day) orally for 4 weeks. We evaluated the histopathological changes, prostate weight, dihydrotestosterone (DHT), prostate specific antigen (PSA), and total antioxidant capacity (TAC) in serum. Moreover, malondialdehyde (MDA), heme oxygenase 1 (HO1), nuclear factor erythroid 2-related factor 2 (Nrf2), caspase3, IL1β expressions, and proliferating cell nuclear antigen (PCNA) were measured in tissue specimens. Our results confirmed the induction of BPH by histopathological examination which revealed typical changes of BPH with dysplastic features. Moreover, there are significant increases in prostate weights, DHT, PSA, PCNA, MDA, and IL1β but significant decreases in TAC, HO1, Nrf2 and caspase 3. Interestingly, DIA significantly improved BPH induced histopathological and biochemical changes that is not differing from control group without dysplastic changes. This is mostly attributed to blocking of IL1β, anti-oxidant, apoptotic properties with activation of Nrf2/HO1 pathway.

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“…Sample absorbance was measured at 450 nm using an Epoch Micro plate Spectrophotometer (BioTek Instruments, Inc., Winooski, VT, USA). The recorded values were in ng/mL [ 41 ].…”

Section: Methodsmentioning

confidence: 99%

Origanum majorana L. Extract Attenuated Benign Prostatic Hyperplasia in Rat Model: Effect on Oxidative Stress, Apoptosis, and Proliferation

et al. 2022

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Benign prostatic hyperplasia (BPH) is a widespread androgenic illness influencing elderly men. It is distinguished by prostatic epithelial and stromal muscle cell proliferation. Inflammation, oxidative stress, and apoptosis have all been interrelated to the development of BPH. Marjoram (Origanum majorana L.) is a herb with reported antiproliferative, proapoptotic, and antioxidative properties, which have not yet been studied in relation to BPH. Consequently, in this work, an ethanolic extract of O. majorana was prepared in two doses (250 and 500 mg/kg/day) to be injected into castrated rats after induction of a testosterone-BPH model. Testosterone propionate (TP) was subcutaneously injected (0.5 mg/kg/day) for one week after castration to induce BPH. Forty adult Wistar male rats were randomly allocated into five groups: control, BPH model, high and low O. majorana doses (250, 500 mg/kg/day), and finasteride (FN) (0.8 mg/kg/day) as a positive control. Treatment was continued with drugs/normal saline for 28 days. Rat’s body and prostate were weighed, prostate index (PI) and % of prostate growth inhibition were calculated, serum dihydrotestosterone (DHT), prostatic content of superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAC), and malondialdehyde (MDA), DN damage, histopathological changes, immune expression of proliferating cell nuclear antigen (PCNA), caspase-3, α-SMA, and TGF-β1 were assessed. In addition, molecular quantitative PCR and ELISA analyses were performed to identify the expression of mRNAs and related proteins of both caspase-3 and TGF-β1 in prostate tissue from O. majorana-treated and untreated groups. Rats with BPH had significantly higher prostate weights and PI, higher DHT, DNA damage (8-hydroxyguanine, 8-OH-dG), and MDA levels with prominent PCNA, α-SMA, and TGF-β expression, but lower SOD, CAT, and TAC activity and caspase-3 expression. O. majorana (250 and 500 mg/kg/day)-treated groups revealed a decrease in prostate weights and PI, lower levels of DHT, suppressed oxidative stress, reduced tissue proliferation and fibrosis, and restored antioxidant and proapoptotic activity. Additionally, quantitative PCR and ELISA analysis showed that treatment with O. majorana significantly upregulated the expression of caspase-3 and downregulated the expression of TGF-β in prostate tissues of BPH rats. The data were confirmed by the immunohistological reactivity of these targeted markers in the prostate tissues. These effects were more significant with O. majorana 500 mg/mL/rat. In conclusion, the current study indicates the efficient use of O. majorana in the treatment of testosterone-induced BPH through its antiproliferative, proapoptotic, and antioxidative mechanisms.

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Cranberry Powder Attenuates Benign Prostatic Hyperplasia in Rats

Cited by 6 publications

References 38 publications

Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats

Administration of Caesalpinia bonduc Seed Extracts Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia (BPH) in Male Wistar Rats

Diacerein ameliorates benign prostatic hyperplasia with dysplastic changes in rats via modulation of IL1β and Nrf2/HO1 pathway

Origanum majorana L. Extract Attenuated Benign Prostatic Hyperplasia in Rat Model: Effect on Oxidative Stress, Apoptosis, and Proliferation

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