Cranio-maxillofacial non-Hodgkin’s lymphoma: Clinical and histological presentation

Scherfler, Sebastian; Freier, Kolja; Seeberger, Robin; Bacon, Claire; Hoffmann, Jürgen; Thiele, Oliver C.

doi:10.1016/j.jcms.2011.10.021

Cited by 23 publications

(35 citation statements)

References 21 publications

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“…Il s'agit rarement d'images osseuses lytiques mal limitées, évocatrices d'une pathologie maligne [1][2][3][4][5][6]13].…”

Section: Symptomatologie Et Signes D'appelunclassified

“…Cette prédominance se retrouve dans diverses études [3,4,9,13] mais elle semble moins franche dans d'autres travaux [2]. Un seul cas présente un lymphome de phénotype T, confirmant l'aspect exceptionnel de cette pathologie dans la sphère oro-faciale [4].…”

Section: Classificationunclassified

“…La région de la tête et du cou est le deuxième site le plus atteint après le tractus gastrointestinal. La cavité buccale et les maxillaires représentent 2 à 3 % des sites extraganglionnaires [1][2][3][4][5][6][7].…”

Section: Introductionunclassified

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Lymphomes malins non hodgkiniens buccaux : À propos de 18 cas

Renard

Canonica

Piral

et al. 2015

Med Buccale Chir Buccale

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Résumé -Introduction : L'atteinte primitive buccale par un lymphome malin non hodgkinien (LMNH) est rare. Matériels et méthodes : Au travers de cette étude rétrospective, une série de 18 cas dont le diagnostic a été le plus souvent difficile, avec de fréquents retards de diagnostic, a été analysée. Les critères évalués étaient les signes d'appel, la symptomatologie de ces LMNH, les différents traitements suivis et l'évolution de chaque patient. Résultats : Il existait un grand nombre de LMNH de différents types dans cette étude ; les LMNH diffus à grandes cellules B étant les plus fréquents. Une des difficultés diagnostiques était liée à la grande variabilité clinique des symptômes sans signe pathognomonique. Indépendamment de la classification histologique des LMNH, les protocoles thérapeutiques associaient radiothérapie et chimiothérapie. Discussion : Malgré un fréquent retard de diagnostic, le pronostic du LMNH reste bon grâce aux protocoles thérapeutiques appropriés. L'enjeu majeur pour le spécialiste de la cavité orale est une détection plus précoce.Abstract -Malignant non-hodgkin's lymphoma of the oral cavity: a survey of 18 cases. Introduction: Primary malignant non-Hodgkin's lymphoma (MNHL) is a very uncommon lesion of the jaws and the oral cavity. Materials and Methods: In this retrospective study, a survey of 18 cases of MNHL was performed. The clinical presentation, histological subtype, mode of treatment and long-term prognosis were assessed. Results: Many subtypes of MNHL were noted in this survey; diffuse large B-cell lymphoma was the most frequent subtype. One of the greatest difficulties for the diagnosis was the wide clinical variability of the symptoms without any pathognomonic features. The standard treatment protocol associated chemotherapy with radiotherapy. Discussion: Unless there is a prolonged delay in diagnosis, the prognosis is good thanks to adequate therapeutic protocols. The main and crucial point is the earliest possible detection in patients by oral surgeons and dentists.

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“…Il s'agit rarement d'images osseuses lytiques mal limitées, évocatrices d'une pathologie maligne [1][2][3][4][5][6]13].…”

Section: Symptomatologie Et Signes D'appelunclassified

Section: Classificationunclassified

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Lymphomes malins non hodgkiniens buccaux : À propos de 18 cas

Renard

Canonica

Piral

et al. 2015

Med Buccale Chir Buccale

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“…Even though lymphomas represent approximately 5% of malignant neoplasm of the head and neck region, they are the second most common malignant lesions after the squamous cell carcinoma [1,2]. These lymphomas mainly consist of non-Hodgkin's lymphomas (NHLs).…”

Section: Introductionmentioning

confidence: 99%

“…Occurrence of lymphoma in the oral cavity is relatively rare, accounting for approximately 3.5% of oral malignancies [4]. Diffuse large B-cell lymphoma (DL-CBL) is the most common form, followed by follicular lymphoma (FL) [2]. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) is also frequent in the oral and maxillofacial region.…”

Section: Introductionmentioning

confidence: 99%

Follicular Lymphomas of Oral Region Treated by Rituximab Monotherapy: About Two Cases

Montaner¹,

Weingertner²,

Ledoux³

et al. 2018

J Hematol

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Lymphomas represent the second most common malignant lesions of the head and neck. Among them, follicular lymphomas (FLs) are the second most frequent B-cell non-Hodgkin's lymphomas. However, their incidence is rare in the oral cavity. We describe here two cases of FL with initial intra-oral presentation. The first patient was 81 years old and presented a palatal hyperplasia, covering the posterior edge of her dental removable prosthesis. After surgical excision of the lesion, the pathological diagnosis was an extra-nodal low-grade follicular lymphoma. Medical imaging assessment found a widespread but non-bulky involvement. The second patient was 38 years old and referred for asymptomatic swelling of the lower vestibule evolving for 4 months. Surgical exploration revealed a cheek lymphadenopathy infiltrated by a grade 3 FL; this patient did not have any other localization. Both patients were treated by a rituximab monotherapy with excellent response after 2 years of follow-up. Most of the time, FL affecting the oral cavity presenting as unspecific swelling, can mimic other frequent and benign oral lesions. In the absence of biopsy, both diagnosis and proper onco-hematological management may be delayed. The introduction of monoclonal antibody rituximab represents a major advance in the management of FL: it can be used as monotherapy or may be combined with chemo-immunotherapy according to histological grading, initial staging (extent, tumor mass or bulk), age and co-morbidities. These two observations show the importance of an early diagnosis regarding a chronic lesion in the oral cavity. Painless lymphadenopathy, asymptomatic swelling, aspecific mucosal lesions, or subprosthetic lesions should draw attention of any oral specialist.

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