Craniofacial Characteristics of Thalassemia Major Patients

Karakaş, Sacide; Tellioğlu, Ayfer Metin; Bilgin, Mehmet; Ömürlü, İmran Kurt; Çalışkan, Serçin Özlem; Coşkun, Salih

doi:10.5152/eurasianjmed.2016.150013

Cited by 20 publications

(32 citation statements)

References 14 publications

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“…Initial observational studies of the craniofacial complex of thalassaemia patients have shown that they are more prone to a Class II skeletal pattern (increased facial convexity with the mandible positioned posteriorly www.nature.com/scientificreports/ at the sagittal level in relation to the maxilla), without being able to define the exact structural differences from the normal population that could support their findings 10,11 . Further observational anthropometric studies are available 14,[32][33][34][35][36] , while 6 more studies [15][16][17][37][38][39] and one systematic review 40 could be found in the literature. These studies used conventional cephalometrics to compare beta thalassaemia patients with controls.…”

Section: Discussionmentioning

confidence: 99%

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

Ρούσσος

Mitsea

Halazonetis

et al. 2021

Sci Rep

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The shape of the craniofacial complex of patients with beta thalassaemia was evaluated using geometric morphometrics on lateral cephalometric radiographs and was compared with matched controls. The beta thalassaemia group consisted of 40 patients (16 females, 24 males, mean age 33.4). Each patient was matched by age and gender to two controls (32 females, 48 males, mean age 33.1). The 120 lateral cephalometric radiographs were digitized and traced with 15 curves, 10 landmarks and 117 sliding semi-landmarks. These landmarks were subjected to Procrustes superimposition and principal component analysis in order to describe shape variability of the cranial base, maxilla and mandible, as well as of the entire craniofacial complex for each sex. The first 4 principal components accounted for 50% of the total sample’s variability. The beta thalassaemia group was significantly different in overall shape to the control group for both sexes. Similar findings were noted for the maxilla, the mandible and the cranial base. The main differences were related to smaller mandibular body for the thalassaemia group, midface protrusion and decrease in posterior face height. The shape of the craniofacial complex in these patients is prone to be more convex and hyperdivergent.

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Section: Discussionmentioning

confidence: 99%

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

Ρούσσος

Mitsea

Halazonetis

et al. 2021

Sci Rep

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“…6 This finding of present study also commensurate with the study of Karakas S et al who concluded significantly larger total upper lip height (sn-sto) in their study. 1…”

Section: Discussionmentioning

confidence: 99%

ASSOCIATION OF OROFACIAL FEATURES OF Β-Thalassemia MAJOR PATIENTS

Gupta¹,

Arora²

2018

jemds

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BACKGROUND Patients with β-thalassemia major or Cooley's anaemia will have severe anaemia, which triggers several defence mechanisms in the body, the most significant of which is the expansion of bone marrow. This expansion of bone marrow in turn forces the bones to expand, produces deformities of the skull and face bones. The purpose of this study was to find out the relationship between different orofacial parameters of labio-oral region in patients with β-thalassemia major and to identify differences by comparing them with age and sex matched controls. MATERIALS AND METHODS A case-control study was carried out in 400 study participants (200 cases and 200 controls). Mouth breadth (ch-ch), Height of integumental lips (ls-li) and Height of the total upper lip (sn-sto) of all the study participants were measured. RESULTS All the measurements used in the present study except height of integumental lips were found significantly associated in sex-wise subgroups as well as in overall study group. CONCLUSION The result of the present study increased our knowledge about orofacial anatomy of β-thalassemia major patients and enabled us to achieve quantitative results.

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“…Thalassemia are group of single gene inherited hematological disorders caused by deficiencies in the synthesis of hemoglobin chains that cause haemolytic anemia . [1] . ß-thalassemia major is the most severe form leading to severe anemia in infancy or childhood and used to be life threatening in absence of regular red cell transfusions [2] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Blood Groups and Complications on Orofacial Measurements of B Thalassemia Adult Patients

Mohammed¹,

Abdullah²,

Al-Taee³

2021

MLU

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Background: β-thalassaemia is a common hereditary disorders in Iraq and worldwide .with different treatment schemes,, including blood transfusion, iron chelation and splenectomy, patients with B thalassemia may develop different skeletal changes. Limited studies link these complications with orofacial changes, This study aimed to evaluate the orofacial dimensions in β-thalassemia patients with age, gender, blood groups, splenectomy and cholecystectomy and to assist surgeons for planning their future intervention.Method: This study was conducted on 130 ß-thalassemia patients of both gender,,and two age categories (20-30 yrs), & (21-40 yrs), five orofacial measurements (face,eyes,nose,mouth and ears) and sixteen parameters were measured and calculated for differences,P value is estimated,data analysis were done by using Chi square test and SPSS version 20 Results: Significant findings were found for mandibular width and mouth width at older age group (31-40 years), the nasal width and ear height are more in male, patients with splenectomy have significance for lower 1\3 face and ear width. Cholecystectomy increase eye length measurments and ear height but for blood groups the P ˃ 0.05 Conclusions: Orofacial bone changes are pronounced in β-thalassaemia with distinct findings regarding sex dimorphism, older are more prone to have variations, earlier splenectomy is advisable,cholecystectomy is better choice for symptomatic patients, blood groups have no significance.

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Craniofacial Characteristics of Thalassemia Major Patients

Cited by 20 publications

References 14 publications

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

ASSOCIATION OF OROFACIAL FEATURES OF Β-Thalassemia MAJOR PATIENTS

Effect of Blood Groups and Complications on Orofacial Measurements of B Thalassemia Adult Patients

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