Cranioplasty Using a Novel Osteoconductive Scaffold and Platelet Gel

Tseng, Ching Li; Chang, Guang Wei; Ou, Kuang‐Ling; Chou, Wan-Jung; Wu, Te Hsing; Fang, Hsu Wei; Tsai, Jui-che; Chen, Tim Mo

doi:10.1097/sap.0000000000000696

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Some of recent experimental studies were summarized in Table 2. [37][38][39][40][41][42][43][44][45][46][47][48][49][50] Research areas included deep second-degree burns, decubitus ulcers, abdomen wound, surgical skin wound, methicillin-resistant Staphylococcus aureus (MRSA)-related wound, and bone defect. The assesses were various, such as gross morphologic, GFs assay, histology examine, immunostaining analysis, laser doppler, energy dispersive X-ray, computed tomographic scan, 3D computed tomographic scan, scanning electron microscopy, and transmission electron microscopy.…”

Section: Animal Studiesmentioning

confidence: 99%

Current applications of platelet gels in wound healing—A review

Wang

Yang

Zhao

et al. 2021

Wound Repair Regeneration

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Human platelets play important roles in several physiologic and pathologic processes.Platelet concentrates are activated with thrombin or calcium, resulting in a viscous coagulum (platelet gel [PG]), composed of 95% platelets at least. PG is increasingly used for the treatment of a variety of soft and hard tissue defects, most notably in the management of chronic non-healing wounds. During wound healing, platelets not only play a critical role in primary hemostasis and thrombosis, but also release growth factors and cytokines to promote tissue regeneration, enhance collagen synthesis, and trigger an immune response. This review addresses a variety of aspects relevant to the functions of well-known platelet growth factors, animal and clinical studies of PG in the last decade, and different sources of platelets for PG. PG is used for nonhealing chronic wounds, such as oral ulcerations related to epidermolysis bullosa and chronic graft-versus-host disease, for those, the traditional treatment effect is poor.PG maybe provide a new therapeutic direction for these diseases. Nevertheless, some uncertainty is present, the number of clinical studies is not enough. Hence, randomized controlled trials are still required to study the potential of the use of PG in the near future. K E Y W O R D Splatelet gel, platelet growth factor, platelet-rich plasma, wound healing | INTRODUCTIONOver the past three decades, extensive cellular and molecular details were elucidated regarding the regulation of cutaneous wound healing. 1,2 Although platelets are fundamental components of the hemostatic response to vessel damage. It is worth noting that platelet rich plasma (PRP) gel/platelet gel (PG) is increasingly used for the treatment of a variety of soft and hard tissue defects, most notably in the management of chronic non-healing wounds and in accelerating bone formation. [3][4][5][6][7][8] Wound healing is a very intricate process involving the complex interplay of numerous humoral factors and cells. PG as a new application was proposed during the last 30 years, to favour wound healing through the growth factors (GFs) released by platelets during clotting. Platelet concentrates are activated with thrombin or calcium, which induces the release of GFs and also fibrin generation, resulting in a viscous coagulum (PG), composed of 95% platelets at least. 9 A wound is defined as damage or disruption to the normal anatomical structure and function, and it may cause damage in other structures such as tendons, muscles, vessels, nerves, parenchymal

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Section: Animal Studiesmentioning

confidence: 99%

Current applications of platelet gels in wound healing—A review

Wang

Yang

Zhao

et al. 2021

Wound Repair Regeneration

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“…Они несут в себе сигнальные молекулы либо стволовые клетки, запускающие процессы регенерации кости, т.е. обладают сильным остеоиндуктивным действием [11][12][13]. К недостаткам подобных матеиалов относят их высокую уязвимость к переломам и сложности использования в местах мозговых синусов.…”

Section: металлы и синтетические материалыunclassified

Modern materials for the reconstruction of the cranial vault bones

Офицеров¹,

Borovkova²,

Talypov³

et al. 2019

Transplantologiâ (Mosk.)

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Introduction. The need for cranioplasty occurs after the removal of the bony structures of the cranial vault. Craniotomy can be performed both in emergency as in case of increased intracranial pressure, and as a planned operation in the treatment of neoplasms or abscesses. A long-lasting presence of an extensive bone defect is the cause of the "trephined skull" syndrome development. Currently, cranioplasty is performed with materials of synthetic or natural origin. Synthetic materials include hydroxyapatite, tricalcium phosphate, polymethyl methacrylate. The natural materials include the auto-, allo- and xenografts. The main disadvantage of bone autografts is their rapid lysis. The most promising solution to this problem may include a lyophilization method with transplant saturation with growth factors, the source of which can be autoplasma rich in platelets. Of particular relevance is the development of methods for the preparation and preservation of an autograft, its modification in order to increase osteoreparative properties, which will bring the cranioplasty method with natural transplants to a whole new level.The purpose of research. Combine relevant data and the results of a comprehensive analysis of the advantages and disadvantages of existing bone-plastic materials.

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“…An early description of this surgery stated that “postoperative analgesia was not considered necessary” [9]. Recent publications using this model fail to provide sufficient information on perioperative animal management [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24] and do not comply with ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines [25]. It is possible that many experimental rabbits undergoing this procedure receive inappropriate perioperative analgesia.…”

Section: Introductionmentioning

confidence: 99%

Anaesthetic and Perioperative Management of 14 Male New Zealand White Rabbits for Calvarial Bone Surgery

Raillard

Detotto

Grepper

et al. 2019

Animals

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Simple SummaryBone substitutes are commonly used when bone grafts are necessary in human craniofacial surgery. To study the properties and biologic behaviour of those substitutes, they can be implanted in experimental animals. A frequently used model involves the creation of critical-sized defects (defects that are too large to heal by themselves) in the rabbits calvaria (the top part of the skull). The procedure was initially described in 1989 and the authors considered and reported that post-operative analgesia was not necessary. In our experience, this procedure is invasive and can result in severe postoperative pain. The anaesthetic management of rabbits undergoing this procedure is challenging. Most of the recent publications using this model fail to provide sufficient information on perioperative animal management. With this report we have aimed to document a possible practical and simple anaesthetic and postoperative management of rabbits undergoing this procedure. Particular emphasis has been placed on postoperative pain assessment, duration and treatment.AbstractCalvarial bone surgery on rabbits is frequently performed. This report aims to document a simple and practical anaesthetic and perioperative management for this procedure. Fourteen male New Zealand white rabbits were included in the study. Subcutaneous (SC) dexmedetomidine, ketamine and buprenorphine ± isoflurane vaporized in oxygen administered through a supraglottic airway device (V-gel®) provided clinically suitable anaesthesia. Supplemental oxygen was administered throughout recovery. Monitoring was clinical and instrumental (pulse-oximetry, capnography, invasive blood pressure, temperature, arterial blood gas analysis). Lidocaine was infiltrated at the surgical site and meloxicam was injected subcutaneously as perioperative analgesia. After surgery, pain was assessed five times daily (composite behavioural pain scale and grimace scale). Postoperative analgesia included SC meloxicam once daily for four days and buprenorphine every 8 h for three days (unless both pain scores were at the lowest possible levels). Rescue analgesia (buprenorphine) was administered in case of the score > 3/8 in the composite pain scale, >4/10 on the grimace scale or if determined necessary by the caregivers. Airway management with a V-gel® was possible but resulted in respiratory obstruction during the surgery in two cases. Hypoventilation was observed in all rabbits. All rabbits experienced pain after the procedure. Monitoring, pain assessments and administration of postoperative analgesia were recommended for 48 h.

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Cranioplasty Using a Novel Osteoconductive Scaffold and Platelet Gel

Abstract: The use of this novel osteoconductive scaffold combined with osteoinductive platelet gel offers a valuable alternative for the reconstruction of calvarial bone defects.

Cited by 5 publications

References 12 publications

Current applications of platelet gels in wound healing—A review

Current applications of platelet gels in wound healing—A review

Modern materials for the reconstruction of the cranial vault bones

Anaesthetic and Perioperative Management of 14 Male New Zealand White Rabbits for Calvarial Bone Surgery

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