CREAM: a database for chemotherapy resistance-associated miRSNP

Dai, Erfu; Lv, Yingli; Meng, Fanling; Yu, Xiaowen; Zhang, Y; Wang, S; Liu, Xiangqiong; Liu, D; Wang, J; Li, X; Jiang, Wei

doi:10.1038/cddis.2014.236

Cited by 10 publications

(5 citation statements)

References 5 publications

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“…Polymorphisms in miRNA 3′ UTR target sites and/or miRNA gene s have been associated with resistance to chemotherapy in patients suffering from various subtypes of cancer . The CREAM (Chemotherapy ResistancE-Associated MiRSNP) repository lists 150 such SNPs predicted to interfere with 1164 chemotherapy response compounds [ 73 ]. In breast cancer patients with estrogen receptor alpha expression, the acquired resistance to tamoxifen treatment has been associated with an elevated expression of miR-519a, which in turn targets a number of tumor-suppressor mRNAs to decrease the life expectancy of patients [ 74 ].…”

Section: Emerging Pharmacogenomics Due To Mirna-linked Genetic Variationmentioning

confidence: 99%

MicroRNAs in Disease

Papagregoriou

2015

Genomic Elements in Health, Disease and Evolution

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Section: Emerging Pharmacogenomics Due To Mirna-linked Genetic Variationmentioning

confidence: 99%

MicroRNAs in Disease

Papagregoriou

2015

Genomic Elements in Health, Disease and Evolution

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“…MiRSNPs refer to polymorphisms present at, or near-by, the miRNA binding sites of their target genes as well as in those genes that are involved in miRNA biogenesis [100]. MiRSNPs have been shown to influence the drug response by affecting the expression of drug target genes, mostly in the field of cancer chemotherapy response and survival [101].…”

Section: Potential Role Of Mirna Polymorphisms In Drug Response and Ementioning

confidence: 99%

Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World

Nuzziello

Ciaccia

Liguori

2019

Cells

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Novel insights in the development of a precision medicine approach for treating the neurodegenerative diseases (NDDs) are provided by emerging advances in the field of pharmacoepigenomics. In this context, microRNAs (miRNAs) have been extensively studied because of their implication in several disorders related to the central nervous system, as well as for their potential role as biomarkers of diagnosis, prognosis, and response to treatment. Recent studies in the field of neurodegeneration reported evidence that drug response and efficacy can be modulated by miRNA-mediated mechanisms. In fact, miRNAs seem to regulate the expression of pharmacology target genes, while approved (conventional and non-conventional) therapies can restore altered miRNAs observed in NDDs. The knowledge of miRNA pharmacoepigenomics may offers new clues to develop more effective treatments by providing novel insights into interindividual variability in drug disposition and response. Recently, the therapeutic potential of miRNAs is gaining increasing attention, and miRNA-based drugs (for cancer) have been under observation in clinical trials. However, the effective use of miRNAs as therapeutic target still needs to be investigated. Here, we report a brief review of representative studies in which miRNAs related to therapeutic effects have been investigated in NDDs, providing exciting potential prospects of miRNAs in pharmacoepigenomics and translational medicine.

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“…Single-nucleotide polymorphisms (SNPs) are among the most extensively studied genetic variations that may be involved in miRNA regulation. 14 MiRNA-related SNPs (miRSNPs) can influence miRNA expression and their processing kinetics, 15 especially when these miRSNPs occur in the 3′ untranslated regions (3′UTR).…”

Section: Introductionmentioning

confidence: 99%

“…Single‐nucleotide polymorphisms (SNPs) are among the most extensively studied genetic variations that may be involved in miRNA regulation. 14 MiRNA‐related SNPs (miRSNPs) can influence miRNA expression and their processing kinetics, 15 especially when these miRSNPs occur in the 3′ untranslated regions (3′UTR). The 3′ UTRs of messenger RNAs (mRNAs) are well‐known for their role in regulating mRNA‐based processes, including mRNA localization, stability, and translation.…”

Section: Introductionmentioning

confidence: 99%

miRSNP rs188493331: A key player in genetic control of microRNA‐induced pathway activation in hypertrophic scars and keloids

Chen,

Pan,

Chen

et al. 2024

Skin Research and Technology

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BackgroundOur study aims to delineate the miRSNP–microRNA–gene–pathway interactions in the context of hypertrophic scars (HS) and keloids.Materials and MethodsWe performed a computational biology study involving differential expression analysis to identify genes and their mRNAs in HS and keloid tissues compared to normal skin, identifying key hub genes and enriching their functional roles, comprehensively analyzing microRNA‐target genes and related signaling pathways through bioinformatics, identifying MiRSNPs, and constructing a pathway‐based network to illustrate miRSNP‐miRNA‐gene‐signaling pathway interactions.ResultsOur results revealed a total of 429 hub genes, with a strong enrichment in signaling pathways related to proteoglycans in cancer, focal adhesion, TGF‐β, PI3K/Akt, and EGFR tyrosine kinase inhibitor resistance. Particularly noteworthy was the substantial crosstalk between the focal adhesion and PI3K/Akt signaling pathways, making them more susceptible to regulation by microRNAs. We also identified specific miRNAs, including miRNA‐1279, miRNA‐429, and miRNA‐302e, which harbored multiple SNP loci, with miRSNPs rs188493331 and rs78979933 exerting control over a significant number of miRNA target genes. Furthermore, we observed that miRSNP rs188493331 shared a location with microRNA302e, microRNA202a‐3p, and microRNA20b‐5p, and these three microRNAs collectively targeted the gene LAMA3, which is integral to the focal adhesion signaling pathway.ConclusionsThe study successfully unveils the complex interactions between miRSNPs, miRNAs, genes, and signaling pathways, shedding light on the genetic factors contributing to HS and keloid formation.

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CREAM: a database for chemotherapy resistance-associated miRSNP

Cited by 10 publications

References 5 publications

MicroRNAs in Disease

MicroRNAs in Disease

Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World

miRSNP rs188493331: A key player in genetic control of microRNA‐induced pathway activation in hypertrophic scars and keloids

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