Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study

Bekkelund, Svein Ivar; Johnsen, Stein Harald

doi:10.1371/journal.pone.0198133

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…Low serum CK levels maybe a consequence of decreased serum muscle enzyme outflow due to reduced physical activity caused by disease or advanced age ( 40 ). The present observations also confirm the hypothesis that CK is inversely and independently associated with CRP ( 41 ). The absence of statistically significant differences between groups in terms of CK-MB suggests no coexisting heart damage, which may have altered the values of other parameters (CRP, fibrinogen).…”

Section: Discussionsupporting

confidence: 91%

Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients

Matei

Anghel

et al. 2022

Exp Ther Med

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Chronic venous disease (CVD) is a frequently encountered disease that progresses with age. Although the principal method of evaluation and diagnosis is Doppler ultrasound, routine laboratory tests may be an easier and more accessible way to evaluate CVD progression. The present retrospective study evaluated the laboratory results of 256 patients diagnosed with CVD. According to the Clinical, Etiological, Anatomical and Pathophysiological classification, depending on the CVD stage, patients were stratified into three groups: Group 1 (C2-C3; mild disease), Group 2 (C4; moderate to severe disease) and Group 3 (C5-C6; severe disease). The considered parameters were age, red blood cell count (RBC), white blood cell count (WBC) and platelet count (PLT), percentage of neutrophils and lymphocytes, neutrophil-to-lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fibrinogen, prothrombin time (in percentages and seconds), internal normalized ratio, activated partial thromboplastin time, creatine kinase (CK), CK myocardial band, alanine transaminase, aspartate transaminase, total bilirubin and urea. No significant differences among the groups were noted in RBC, WBC, PLT and coagulation factors; on the other hand, inflammatory markers exhibited differences among the groups. Several differences were observed in hepatic, metabolic and muscle tissue markers. Intraluminal thrombus formation in the case of varicose veins (thrombophlebitis) may be due to conditions of turbulent flow, stasis and endothelial inflammation, rather than hypercoagulability. The results of the present study confirmed the implication of inflammatory factors in pathophysiological modifications, including thickening of venous walls and valvular modification, as well as the appearance of intraluminal thrombi and trophic lesions. NLR, ESR, CRP and fibrinogen were increased with CVD progression and may be considered useful markers in evaluating CVD progression. Simple blood tests may provide phlebologists with additional insight for the management of those patients.

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Section: Discussionsupporting

confidence: 91%

Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients

Matei

Anghel

et al. 2022

Exp Ther Med

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“…High-sensitivity C-reactive protein (Hs-CRP) and HbA 1c were measured in the main Tromsø 6 study, as described previously. 30 , 32 …”

Section: Methodsmentioning

confidence: 99%

“…High-sensitivity C-reactive protein (Hs-CRP) and HbA1c were measured in the main Tromsø 6 study, as described previously. 30,32 Blood pressure (BP) was measured three times in a seated position after a 2 min rest period.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population

Melsom

Norvik

Enoksen³

et al. 2021

Kidney International Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…All samples carried out in accordance with relevant guidelines and regulations are described elsewhere [ 20 ]. Serum-CK was obtained in an automated chemistry analyzer (Modular P, Roche) by photometry using an enzymatic method (CK-NAC, Roche Diagnostics, Mannheim, Germany) with an analytical variation coefficient ≤1.6%.…”

Section: Methodsmentioning

confidence: 99%

Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study

Bekkelund

2023

PLoS ONE

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Background Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population. Methods Associations between CK and the outcome variable HbA1C (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA1C (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. Results Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA1C (%) in the “high CK” group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the “normal CK” group, P <0.001. CK increased significantly and linearly with higher levels of HbA1C (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA1C (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA1C (%). Conclusion These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population.

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Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study

Cited by 10 publications

References 39 publications

Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients

Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients

Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population

Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study

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