Creatine kinase-MB fraction elevation after percutaneous coronary intervention in patients with chronic renal failure

Gruberg, Luis; Mehran, Roxana; Waksman, Ron; Dangas, George; Fuchs, Shmuel; Wu, Hongsheng; Kent, Kenneth M.; Pichard, Augusto D.; Satler, Lowell F.; Stone, Gregg W.; Leon, Martin B.

doi:10.1016/s0002-9149(01)01552-1

“…The study by Novack et al 22 in 4930 patients undergoing PCI showed that a postprocedural elevation of CK-MB and cTnI level were correlated with 1-year mortality, and the mortality risk of patients with increased TnI was higher than that for patients with elevated CK-MB levels. Gruberg et al 23 concluded that postprocedural cTnI elevation was an independent predictor for poor long-term (12 months) prognosis in patients with chronic renal failure who underwent PCI, especially in patients with cTnI levels >3 times normal.…”

Section: Discussionmentioning

confidence: 99%

“…The study by Novack et al 22 in 4930 patients undergoing PCI showed that a postprocedural elevation of CK-MB and cTnI level were correlated with 1-year mortality, and the mortality risk of patients with increased TnI was higher than that for patients with elevated CK-MB levels. Gruberg et al 23 concluded that postprocedural cTnI elevation was an independent predictor for poor long-term (12 months) prognosis in patients with chronic renal failure who underwent PCI, especially in patients with cTnI levels >3 times normal. The incidence of cardiovascular events may be affected by myocardial injury after PCI through the following mechanisms: (1) decreased left ventricular function or ventricular arrhythmias via a small reentrant circuit in the ventricle as a result of scar formation due to myocardial necrosis caused by PCI; (2) the increase in markers for myocardial injury might be the markers for diffuse coronary atherosclerosis; and (3) vessels and myocardial cells themselves release markers of myocardial injury during PCI.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Exogenous Creatine Phosphate on Myocardial Injury After Percutaneous Coronary Intervention

Deng

¹

,

Xubo

²

,

Zhao

³

et al. 2013

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“…Although cardiac troponins have high sensitivity in the diagnosis of myocardial injury, an elevation in their levels may be observed in other situations other than cardiac events. 20 In light of these discrepancies, new biomarkers are required and there exists a need to establish an assay system to predict USAP.…”

Section: Discussionmentioning

confidence: 99%

Evaluating Serum Levels of Pentraxin-3, von Willebrand Factor and C-X-C Motif Chemokine Ligand 13 as Inflammatory Markers of Unstable Angina Pectoris

Raygan

¹

,

Mohammadi

²

,

Etminan

³

et al. 2019

IJAAI

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Unstable angina pectoris (USAP) is a complex condition in which widespread coronary inflammatory processes have important implications for clearer understanding of its pathogenesis and also its treatment. This study aimed at evaluating the diagnostic as well as prognostic value of serum inflammatory markers of pentraxin-3 (PTX-3), Von Willebrand Factor (vWf) and C-X-C Motif Chemokine Ligand 13 (CXCL13) in such patients. Out of sixty-nine patients, thirty-nine had USAP, thirty had stable angina pectoris (SAP), and thirty-nine were healthy controls. For all participants, serum PTX-3, vWf and CXCL13 levels were measured using ELISA. For each patient with USAP, the Thrombolysis in Myocardial Infarction (TIMI) and the scores of Global Registry of Acute Coronary Events (GRACE) were calculated to determine the severity of the disease. We, then, analyzed the relation of PTX-3, vWf and CXCL13 levels with TIMI and GRACE scores in patients with USAP. Serum PTX-3, vWf and CXCL13 levels were significantly higher in USAP group than those in either SAP or control groups (p˂0.001). Strong correlation was observed between CXCL13 level and TIMI risk score (p=0.019). In receiver operating characteristic (ROC) curves, area under the curve (AUC) values of PTX3, vWf and CXCL13 for detection of USAP were 0.755, 0.751, and 0.906, respectively. The levels of serum PTX3, vWf and CXCL13 increased in patients with USAP. The notable correlation implied that CXCL13 might be a sensitive and specific biomarker for the diagnosis of USAP as well as its severity. It might also show additional diagnostic values when measured in combination with vWf.

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“…The CK-MB elevation after PCI in CKD patients is associated with increased mortality and in-hospital complications (52).…”

Section: Value Of Biomarkers In Ckd Reliability Of Biomark-ers For Dmentioning

confidence: 99%

The renal patient with coronary artery disease

Gupta

¹

,

Birnbaum

²

,

Uretsky

³

2004

Journal of the American College of Cardiology

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Creatine kinase-MB fraction elevation after percutaneous coronary intervention in patients with chronic renal failure

Cited by 12 publications

References 23 publications

The Effect of Exogenous Creatine Phosphate on Myocardial Injury After Percutaneous Coronary Intervention

The Effect of Exogenous Creatine Phosphate on Myocardial Injury After Percutaneous Coronary Intervention

Evaluating Serum Levels of Pentraxin-3, von Willebrand Factor and C-X-C Motif Chemokine Ligand 13 as Inflammatory Markers of Unstable Angina Pectoris

The renal patient with coronary artery disease

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