Creatine kinase release in acute myocardial infarction: correlation with clinical, electrocardiographic, and pathological findings.

Abstract

Creatine kinase (CK) cardiogram, and serum enzyme changes. Initially serum CK activity in all patients was still within the normal range (< 40 mU/ml). Patients who had had intramuscular injections, direct current shock, or other possible cause of increase in serum CK activity were excluded from the study.Blood for CK determinations was taken at one-, two-, or three-hourly intervals from the time of admission until CK activity had either returned to normal or, in patients who died, was decreasing. CK activity was measured with Boehringer CK activated test sets (Boehringer, Mannheim) at 25sC, with an upper normal value of 40 mU/ml (Szasz, Busch, and Farohs, I970). A 12-lead standard electrocardiogram was recorded on the day of admission and on the following three days. Daily ST segment changes were measured according to the criteria suggested by Reid et al. (I974) and expressed as a percentage of the initial ST segment height. Blood pressure, heart rate, arrhythmias, and clinical events were carefully monitored. The incidence and severity of recurrent chest pain were estimated by the patient's consumption of morphine or its derivatives.A post-mortem examination was performed in 12 patients. For macroscopic observation the heart was cut into slices o.5 cm thick, which were stained with Nitro-BT (Nachlas and Shnitka, I963). As the result of a on 12 May 2018 by guest. Protected by copyright.

The time course in acute myocardial infarction evaluated with precordial mapping and standard ecg

“…Several methods are available for studies of the time course in acute myocardial infarction (Inoue et al, 1977;Mathey et al, 1975;von Essen et al, 1979). All of them are indirect and inexact.…”

Magnetic resonance imaging (MRI) in different stages of myocardial infarction using the contrast agent gadolinium‐DTPA

“…. 1977;Cobb et al, 1979;Mathey et al, 1975;Sobel et al, 1972;Swain et al, 1980;Vatner et al, 1978). Diagnosis of chronic infarction is not difficult (Bodenheimer et al, 1975(Bodenheimer et al, , 1976Hillis and Braunwald, 1977;Selwyn er al., 1977).…”

Extension of myocardial infarction: incidence and prognosis.

“…Kronenberg et al3 reported infarct extension associated with ST elevation in 33% of 27 patients, six of whom died. Mathey et al 4 found that abnormal CK release curves suggesting infarct extension were present in 62% of 40 patients. In a postmortem study, Hutchins and Bulkley5 found histologic evidence of recent foci of necrosis around an infarct in 17% of 76 hearts.…”