Creatine monohydrate attenuates body fat accumulation in children with acute lymphoblastic leukemia during maintenance chemotherapy

Bourgeois, Jacqueline M.; Nagel, Kim; Pearce, Erin; Wright, Marilyn; Barr, Ronald D.; Tarnopolsky, Mark A.

doi:10.1002/pbc.21571

Cited by 29 publications

(22 citation statements)

References 37 publications

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“…Fuld et al (2005) demonstrated that patients with CPOD supplemented with Cr have improved muscle mass, strength, aerobic capacity, and clinical condition compared with non-supplemented patients. Similar benefits from Cr supplementation have also been reported in patients with congenital heart failure (Andrews et al 1998) and acute lymphoblastic leukemia (Bourgeois et al 2008). The therapeutic application of Cr supplementation in patients suffering from long-term bed rest, physical inactive lifestyle, malnutrition and other types of cancer remain to be investigated.…”

Section: Other Therapeutic Applicationsmentioning

confidence: 82%

In sickness and in health: the widespread application of creatine supplementation

et al. 2011

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There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application of Cr supplementation is indeed exciting. Evidences of benefits from this supplement have been reported in a broad range of diseases, including myopathies, neurodegenerative disorders, cancer, rheumatic diseases, and type 2 diabetes. In addition, after hundreds of published studies and millions of exposures creatine supplementation maintains an excellent safety profile. Thus, we contend that the widespread application of this supplement may benefit athletes, elderly people and various patient populations. In this narrative review, we aimed to summarize both the ergogenic and therapeutic effects of Cr supplementation. Furthermore, we reviewed the impact of Cr supplementation on kidney function.

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Section: Other Therapeutic Applicationsmentioning

confidence: 82%

In sickness and in health: the widespread application of creatine supplementation

et al. 2011

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“…The authors found that creatine supplementation had no significant effects on the weight, body mass index, whole body bone mineral content, and fat-free mass. On the other hand, it was observed a reduced gain in body fat on supplemented patients when compared to the control group [13]. This is a pioneer study with humans; however, important limitations need to be addressed.…”

Section: Creatinementioning

confidence: 95%

“…Conversely, it is known that creatine supplementation may counteract the side effects of glucocorticoid administration on skeletal muscle [9]. In order to assess these potential effects, Bourgeois et al (2008) supplemented with creatine monohydrate nine children with acute lymphoblastic leukemia during two periods of 16 weeks interspaced by a wash out period of 6 weeks. During the supplementation protocol, the children also had been submitted to corticosteroids treatment.…”

Section: Creatinementioning

confidence: 99%

“…Recently, some amino acids and other dietary supplements including amine groups (e.g., creatine) have been applied in several sports modalities due to their anabolic effects on skeletal muscle [7,8]. Additionally, these supplements exert positive effects upon several diseases evolving skeletal muscle atrophy [9][10][11], including cancer [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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An overview of amines as nutritional supplements to counteract cancer cachexia

Campos-Ferraz

Andrade

Neves

et al. 2014

J cachexia sarcopenia muscle

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Cancer cachexia is a complex multifactorial syndrome characterized by loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Recently, some amino acids and other amine dietary supplements have been highlighted in medical field due to positive effects upon diseases evolving skeletal muscle atrophy. Therefore, the aim of this brief review is to discuss the putative application of amines as dietary supplements to counteract skeletal muscle wasting on cancer cachexia. Specifically, we focus in two nutritional supplements: (1) branched-chain amino acids (BCAAs) and (2) creatine. Both BCAAs and creatine may attenuate proteolysis and enhance proteins synthesis in skeletal muscle. Although more experimental studies and clinical trials are still necessary to elucidate this therapeutic application, several evidences have demonstrated that amines supplementation is a promising coadjuvant treatment to cancer cachexia.

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“…22 Creatine monohydrate may attenuate corticosteroid-associated increases in body fat accumulation, a common complication of therapy for childhood ALL and lymphoma. 23 The hepatoprotective herb milk thistle is associated with reductions in serum transaminases in children receiving maintenance chemotherapy for ALL.…”

Section: Practicing Integrative Oncology In the Care Of Children Withmentioning

confidence: 99%

Integrative therapies for children with hematological malignancies

Kelly¹

2009

Hematology

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Evidence for integrative therapies (IT) in children with hematological malignancies is slowly evolving. The ideal model of integrative pediatric oncology would offer IT modalities that are deemed safe and effective in conjunction with effective conventional medical treatments. Because of potential interactions, herbs and other dietary supplements should be used with caution, especially during active therapy. Health and wellness should be the emphasis, with IT therapies supporting health promotion and key disease prevention strategies for childhood cancer survivors. All uses, responses, and effects of IT therapies should be carefully documented. A desire to use IT therapies may be an effort to become an active participant in the healing process. Health care providers should encourage, not discourage, this partnership.

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Creatine monohydrate attenuates body fat accumulation in children with acute lymphoblastic leukemia during maintenance chemotherapy

Abstract: Children with ALL treated with corticosteroids as part of a maintenance protocol of chemotherapy showed an increase in % BF that was attenuated by CrM supplementation.

Cited by 29 publications

References 37 publications

In sickness and in health: the widespread application of creatine supplementation

In sickness and in health: the widespread application of creatine supplementation

An overview of amines as nutritional supplements to counteract cancer cachexia

Integrative therapies for children with hematological malignancies

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