Creatine supplementation reduces oxidative stress biomarkers after acute exercise in rats

Deminice, Rafael; Jordão, Alceu Afonso

doi:10.1007/s00726-011-1121-x

Cited by 49 publications

(31 citation statements)

References 36 publications

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“…In this work, the adenine – treated rats exhibited the urinary and plasma profile of several traditional and novel markers of renal damage, as reported by us and others [20], [36], [37]. Most of these were improved in rats given either GA or SE, and even more so in rats given GA and subjected to SE at the same time, supporting our hypothesis that the ameliorative action of GA on adenine- induced CRF is further enhanced by SE.…”

Section: Discussionsupporting

confidence: 89%

Does Swimming Exercise Affect Experimental Chronic Kidney Disease in Rats Treated with Gum Acacia?

Ali

Al-Salam²,

Za’abi

et al. 2014

PLoS ONE

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Different modes of exercise are reported to be beneficial in subjects with chronic kidney disease (CKD). Similar benefits have also been ascribed to the dietary supplement gum acacia (GA). Using several physiological, biochemical, immunological, and histopathological measurements, we assessed the effect of swimming exercise (SE) on adenine –induced CKD, and tested whether SE would influence the salutary action of GA in rats with CKD. Eight groups of rats were used, the first four of which were fed normal chow for 5 weeks, feed mixed with adenine (0.25% w/w) to induce CKD, GA in the drinking water (15% w/v), or were given adenine plus GA, as above. Another four groups were similarly treated, but were subjected to SE during the experimental period, while the first four groups remained sedentary. The pre-SE program lasted for four days (before the start of the experimental treatments), during which the rats were made to swim for 5 to 10 min, and then gradually extended to 20 min per day. Thereafter, the rats in the 5th, 6th, 7th, and 8th groups started to receive their respective treatments, and were subjected to SE three days a week for 45 min each. Adenine induced the typical signs of CKD as confirmed by histopathology, and the other measurements, and GA significantly ameliorated all these signs. SE did not affect the salutary action of GA on renal histology, but it partially improved some of the above biochemical and physiological analytes, suggesting that addition of this mode of exercise to GA supplementation may improve further the benefits of GA supplementation.

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Section: Discussionsupporting

confidence: 89%

Does Swimming Exercise Affect Experimental Chronic Kidney Disease in Rats Treated with Gum Acacia?

Ali

Al-Salam²,

Za’abi

et al. 2014

PLoS ONE

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“…CMH supplementation with a dose of 1200 mg/kg significantly decreased the contents of lactate and GP in pectoralis major muscle, indicating that the reduction muscle glycolysis by CMH supplementation is probably the reason for maintain meat quality of transported broilers. In addition, it has been demonstrated that creatine can attenuate acute stress responses via direct antioxidant activity (Lawler et al, 2002;Deminice and Jordao, 2012). We thus recommended that further studies are needed to investigate whether the protective effect of CMH supplementation for maintaining meat quality in transported broilers is also closely related to its antioxidant activity.…”

Section: Creatine Monohydrate In Transported Broilersmentioning

confidence: 99%

“…They found that CMH can not only increase growth of pigs (James et al, 2002), but also help to improve the quality of chicken meat (Young et al, 2004). In addition, some studies also reported a new function of creatine to attenuate acute stress responses by effectively quenching superoxide anions and other aqueous radicals (Lawler et al, 2002;Deminice and Jordao, 2012). However, there is limited information concerning the effects of CHM on muscle energy metabolism and meat quality of broiler chickens when experiencing transport stress.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary supplementation with creatine monohydrate during the finishing period on growth performance, carcass traits, meat quality and muscle glycolytic potential of broilers subjected to transport stress

Zhang

Gao

et al. 2014

Animal

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A total of 320 male Arbor Acres broiler chickens (28 days old) were randomly allotted to one of the three experimental diets supplemented with 0 (160 birds), 600 (80 birds) or 1200 mg/kg (80 birds) creatine monohydrate (CMH) for 14 days. On the morning of 42 day, after an 8-h fast, the birds of CMH-free group were divided into two equal groups, and all birds of these four groups were transported according to the follow protocol: 0.75-h transport without CMH supplementation (as a lower stress control group), 3-h transport without CMH supplementation, 3-h transport with 600 or 1200 mg/kg CMH supplementation. Each treatment group was composed of 8 replicates with 10 birds each. The results showed that supplementation of CMH for 14 days before slaughter did not affect the overall growth performance and carcass traits of stressed broilers (P>0.05). A 3-h transport decreased plasma glucose concentration, elevated plasma corticosterone concentration, increased bird live weight loss, breakdown of muscle glycogen, as well as the accumulation of muscle lactate (P<0.05), which induced some detrimental changes to breast meat quality (lower ultimate pH and higher drip loss, P<0.05). Nevertheless, supplementation of 1200 mg/kg CMH reduced chicken weight loss, decreased the contents of lactate and glycolytic potential in pectoralis major of 3-h transported broilers (P<0.05), which is beneficial to maintain breast meat quality by reducing the drip loss (P<0.05). These findings suggest that the reduction of muscle glycolysis is probably the reason for maintainance of meat quality by supplementation of CMH in transported broilers.

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“…According to Deminice and Jordao (2012), Cr supplementation can decrease oxidative stress markers in plasma and muscle after a moderate aerobic exercise like swimming. Creatinesupplemented rats demonstrate antioxidant and protective effects, decreasing reactive oxygen species (ROS) when compared with rats without supplementation.…”

Section: Introductionmentioning

confidence: 99%

The effects of different doses of oral creatine supplementation on tibial muscle resistence and fatigue in wistar rats

Coelho¹,

Carvalho²,

Saltorato³

et al. 2017

Biosci. J.

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ABSTRACT:The aim of the present study was to investigate the effects of different doses of oral creatine supplementation on tibial muscle resistance and fatigue in Wistar rats. The treatment protocols included swimming exercises, supplementation alone (different doses), and supplementation (different doses) + swimming exercises. Analysis of the effect of creatine supplementation on skeletal muscle fatigue was performed using the intensity of muscle contraction to electrical stimulation to evaluate the intensity of muscle contraction, decay time of muscle tetanic contraction to 50% of maximum tension (fatigue), and the area under the curve for the intensity x time ratio, besides AST, LDH, and urea plasmatic analysis. Our results suggest that creatine supplementation seems to be able to produce ergogenic effects on contractile metabolism in the group treated with the dose of 280 mg/kg + swim exercise. This creatine dose presented a statistically significant increase in decay time of muscle tetanic contraction (C280+swim (119±13.1), C500+swim (110±23.6) and C1000+swim (87±15.1)), area under the curve between tetanic contractions, and plasma LDH decrease, when compared to the other doses. These data clearly demonstrate that high doses do not lead to any additional ergogenic effects. We conclude that the dose of 280 mg/kg+swim exercise obtained the best ergogenic effects on tibial muscle resistance and fatigue in Wistar rats.

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Creatine supplementation reduces oxidative stress biomarkers after acute exercise in rats

Cited by 49 publications

References 36 publications

Does Swimming Exercise Affect Experimental Chronic Kidney Disease in Rats Treated with Gum Acacia?

Does Swimming Exercise Affect Experimental Chronic Kidney Disease in Rats Treated with Gum Acacia?

Effects of dietary supplementation with creatine monohydrate during the finishing period on growth performance, carcass traits, meat quality and muscle glycolytic potential of broilers subjected to transport stress

The effects of different doses of oral creatine supplementation on tibial muscle resistence and fatigue in wistar rats

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