Creating a “Pro-Survival” Phenotype Through Epigenetic Modulation

Li, Y.; Liu, B.; Gu, Xuesong; Kochanek, Ashley R.; Fukudome, Eugene Y.; Velmahos, George C.; DeMoya, Marc; Libermann, Towia A.; Alam, Hasan B.

doi:10.1016/j.jss.2011.11.221

Cited by 1 publication

(1 citation statement)

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“…Li et al first illustrated suberoylanilide hydroxamic acid (SAHA) as a histone deacetylase inhibitor to protect mice against LPS-induced septic shock. SAHA reversed the downregulation of histone acetylation caused by LPS, reduced TNF-α and IL-6 expression, and improved long-term survival after LPS stimuli [122,123]. Their further study reveals SAHA also inhibits CitH3 triggering, which is associated with a better septic prognosis [124].…”

Section: Treatments Targeting Histone Modifications In Sepsismentioning

confidence: 89%

Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification

Shi

Zhang

et al. 2023

Cell Death Dis

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Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated immune responses and multiple organ dysfunction. The imbalance between hyperinflammation and immunosuppression is a crucial feature of sepsis immunity. Epigenetic modifications, including histone modifications, DNA methylation, chromatin remodeling, and non-coding RNA, play essential roles in regulating sepsis immunity through epi-information independent of the DNA sequence. In recent years, the mechanisms of histone modification in sepsis have received increasing attention, with ongoing discoveries of novel types of histone modifications. Due to the capacity for prolonged effects on immune cells, histone modifications can induce immune cell reprogramming and participate in the long-term immunosuppressed state of sepsis. Herein, we systematically review current mechanisms of histone modifications involved in the regulation of sepsis, summarize their role in sepsis from an immune perspective and provide potential therapeutic opportunities targeting histone modifications in sepsis treatment.

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Section: Treatments Targeting Histone Modifications In Sepsismentioning

confidence: 89%