Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens

Lei, Ming; Wu, Si; Shao, Xingfeng; Li, X.W.; Chen, Z.; Ying, Shijia; Shi, Zhen‐Dan

doi:10.1016/j.domaniend.2014.09.001

Cited by 14 publications

(4 citation statements)

References 67 publications

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“…Serum testosterone concentrations were determined by an ELISA using the quantitative Diagnostic Kit for testosterone (North Institute of Biological Technology, Beijing, China) [ 23 ]. Concentrations of glucose, triglycerides, cholesterol, high-density lipoprotein, and low-density lipoprotein were measured by using a ROCHE Modular P800 Automatic Biochemical Analyzer (Roche, Milan, Italy) [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of Caponization on Growth Performance and Carcass Composition of Yangzhou Ganders

Lei

Dai

et al. 2022

Animals

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In this study, we determined the effects of caponization on the growth performance and carcass traits of Yangzhou ganders. Fifty sham operated geese (the control group) and 80 caponized geese (the caponized group) were selected at 150 days of age and reared until 240 days of age. At 210 days of age, 30 geese from the caponized group were selected and fed with testosterone propionate (testosterone group). The results showed that caponization lowered testosterone and increased the total cholesterol and triglyceride concentrations in serum, live weights, average 15 day gains, and feed intake. Abdominal fat and intramuscular fat were significantly higher in the caponized geese than in the control at 240 days. Gene expression analysis showed that caponization promoted abdominal fat deposition and intermuscular fat content by upregulating the expression of adipogenic genes in the liver, adipose tissue, and muscle tissue. The high expression of SOCS3 in the hypothalamus, liver, and muscle of caponized geese suggests that caponization may lead to negative feedback regulation and leptin resistance. Changes in the expression of these genes, along with the downregulation of PAX3 in the breast muscle and MYOG in the leg muscles, indicate that caponization increases the live weight mainly by increasing fat deposition rather than muscle growth. These results expand our understanding of the mechanisms of caponization on growth performance and fat deposition in ganders.

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Section: Methodsmentioning

confidence: 99%

Effects of Caponization on Growth Performance and Carcass Composition of Yangzhou Ganders

Lei

Dai

et al. 2022

Animals

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“…Immunization against the LEP receptor downregulated egg production and follicular development and lowered fat deposition in growing chickens [ 107 , 108 ]. Higher body fat is directly proportional to lower sperm concentration, sperm motility, and T in males [ 109 , 110 ].…”

Section: Methods To Improve Reproductive Efficiency Of Gandersmentioning

confidence: 99%

Improving Gander Reproductive Efficacy in the Context of Globally Sustainable Goose Production

Akhtar

Shafiq

Ali

2021

Animals

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The goose is a popular poultry species, and in the past two decades the goose industry has become highly profitable across the globe. Ganders low reproductive performance remains a barrier to achieving high fertility and hatchability in subsequent flocks. To address the global demand for cheaper animal protein, various methodologies for improving avian (re)production should be explored. A large amount of literature is available on reproduction traits and techniques for commercial chicken breeder flocks, while research on improved reproduction in ganders has been carried out to a lesser extent. The present review aims to provide a comprehensive literature overview focusing on recent advancements/techniques used in improving gander reproductive efficacy in the context of ensuring a globally sustainable goose industry.

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“…Despite this experiment, the molecular mechanism of LEP-R-mediated signal transduction pathways is unclear in adipocytes (Adachi et al, 2008). The availability of a functional chicken leptin receptor prompts studies targeting leptin receptor, which substantially augmented leptin bioactivities in both chicken hens and pullets (Lei et al, 2015). 4.1.3.…”

Section: Receptor and Cell Signallingmentioning

confidence: 99%

Adipokines in metabolic and reproductive functions in birds: An overview of current knowns and unknowns

Bernardi

Estienne

Reverchon

et al. 2021

Molecular and Cellular Endocrinology

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Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens

Cited by 14 publications

References 67 publications

Effects of Caponization on Growth Performance and Carcass Composition of Yangzhou Ganders

Effects of Caponization on Growth Performance and Carcass Composition of Yangzhou Ganders

Improving Gander Reproductive Efficacy in the Context of Globally Sustainable Goose Production

Adipokines in metabolic and reproductive functions in birds: An overview of current knowns and unknowns

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