Creating three dimensional models of Alzheimer’s disease

Marks, Matthew; Alexander, Amy E.; Matsumoto, Joseph Y.; Matsumoto, Jane M.; Morris, Jonathan M.; Petersen, Ronald C.; Jack, Clifford R.; Oishi, Tatsuya; Jones, David T.

doi:10.1186/s41205-017-0020-5

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…This work aims to enhance current knowledge regarding how to enable the use of emerging 3D technologies in the medical eld (16) for the development of a model for research on neurodegenerative diseases; we chose the hippocampus for its relationship with memory processes (17) and its involvement in pathologies such as epilepsy (18) and Alzheimer's disease (19). Thus, the results analyze the acquisition of magnetic resonance images and the translation to the 3D printer using Fusion deposit modeling (FDM).…”

Section: Discussionmentioning

confidence: 99%

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Polymer and bioink mixed strategy for human 3D printed Hippocampus model development

Rodrigues

Zanirati

Ghilardi

et al. 2022

Preprint

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Science development can be directly correlated with the models and technologies applied to best simulate the analyzed environment in relation to the clinical reality to be studied and treated. 3D printers and bioinks enable the information acquisition from a clinical imaging environment and replicate it in an experimental one, such as cultured cells, with individual anatomical fidelity and control of cell layers, which mimic real tissue. Neuronal tissue greatly benefits from this approach because it´s a tissue hard to get samples, controls and with limitations in current cell culture monolayer models. Our results demonstrate the development of a model of human hippocampus with anatomical fidelity from magnetic resonance, printed with 3D technology in polylactic acid (PLA) polymer and brain decellularized tissue bioink. Therefore, we performed a screening aiming to determine the best materials. We performed hydrophobicity, surface morphology, cell viability, direct and indirect adhesion assays in the polymers, resulting in PLA among the best performing materials. Then we demonstrated a 3D model to comprehend hippocampus anatomy and histological complexity. Our results combine different expertise in the development of a model with the potential to enhance the study and application of therapeutic strategies regarding hippocampus pathologies.

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Section: Discussionmentioning

confidence: 99%

“…The work from Mark and colleges. provides a solid model of the hippocampus (19). These models can be used to aid in medical diagnosis, histology (26), as a surgical targeting tool (27), and for teaching (16).…”

Section: Discussionmentioning

confidence: 99%

Polymer and bioink mixed strategy for human 3D printed Hippocampus model development

Rodrigues

Zanirati

Ghilardi

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…They also pointed out the models were important tools in medical students and patient education. Marks et al [112] also made a contribution to the models for education, they directly 3D printed the models in some stages of Alzheimer's disease (Figure 7C). Some other hard materials are also used for direct 3D printing of such models, including thermoplastics and photopolymer resins.…”

Section: Neurosurgerymentioning

confidence: 99%

3D Printing of Physical Organ Models: Recent Developments and Challenges

Jin

Kang

et al. 2021

Advanced Science

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Physical organ models are the objects that replicate the patient-specific anatomy and have played important roles in modern medical diagnosis and disease treatment. 3D printing, as a powerful multi-function manufacturing technology, breaks the limitations of traditional methods and provides a great potential for manufacturing organ models. However, the clinical application of organ model is still in small scale, facing the challenges including high cost, poor mimicking performance and insufficient accuracy. In this review, the mainstream 3D printing technologies are introduced, and the existing manufacturing methods are divided into "directly printing" and "indirectly printing", with an emphasis on choosing suitable techniques and materials. This review also summarizes the ideas to address these challenges and focuses on three points: 1) what are the characteristics and requirements of organ models in different application scenarios, 2) how to choose the suitable 3D printing methods and materials according to different application categories, and 3) how to reduce the cost of organ models and make the process simple and convenient. Moreover, the state-of-the-art in organ models are summarized and the contribution of 3D printed organ models to various surgical procedures is highlighted. Finally, current limitations, evaluation criteria and future perspectives for this emerging area are discussed.

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“…As a result, this can translate into reduced operating time, cost, and risks, especially when patients have deformities or anatomical abnormalities [197]. To date, anatomical replicas of various organs, such as kidney, heart, ureter, liver and even brain, have been beneficial for preoperative planning [198][199][200].…”

Section: Overview Of Current Biomedical Applicationsmentioning

confidence: 99%

Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges

Ghilan¹,

Chiriac²,

Niţă³

et al. 2020

J Polym Environ

145

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Additive manufacturing (AM) is considered the latest technology that creates breakthrough innovations and addresses complex medical problems. This is clearly demonstrated by the promising results obtained in regenerative medicine, diagnosis, implants, artificial tissues and organs. This paper provides a basic understanding of the fundamentals of 3D/4D printing along with bioprinting processes. We are briefly discussing about the main printing systems including stereolithography, inkjet 3D printing, extrusion, laser-assisted printing, selective laser melting and Poly-Jet printing. The basic requirements for the selection of successful inks based on polymers, polymer blends, and composites are described. Furthermore, the on-going transition from 3D to 4D printing is highlighted with emphasis on the newest applications in the medical area. Also, a glimpse into the future possibilities and benefits provided by machine learning in the additive manufacturing field is emphasized. Machine learning can improve printing efficiency by using generative design and testing in the pre-fabrication stage. Finally, important limitations and prospects are identified. Within the next few years, AM is set to become an important component in patient-specific medical technologies.

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Creating three dimensional models of Alzheimer’s disease

Cited by 9 publications

References 16 publications

Polymer and bioink mixed strategy for human 3D printed Hippocampus model development

Polymer and bioink mixed strategy for human 3D printed Hippocampus model development

3D Printing of Physical Organ Models: Recent Developments and Challenges

Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges

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