Creatinine- vs. cystatin C-based equations compared with 99mTcDTPA scintigraphy to assess glomerular filtration rate in chronic kidney disease

Trimarchi, Hernán; Muryan, Alexis; Martino, Diana; Toscano, Agostina; Iriarte, Romina; Campolo-Girard, Vicente; Forrester, Mariano; Pomeranz, Vanesa; Fitzsimons, Clara; Lombi, Fernando; Young, Pablo; Rana, MA; Alonso, Mirta

doi:10.5301/jn.5000083

Cited by 29 publications

(41 citation statements)

References 37 publications

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“…Generally, patients with concomitant diseases or chronically taking medications are known to have less reliable GFR measured by DTPA (probably because of alterations in protein-binding of DTPA) [30]. We are also not sure if and how an increased ratio of fat tissue may influence reliability and reproducibility of the DTPA scintigraphic measurement of GFR [31].…”

Section: Discussionmentioning

confidence: 99%

Glomerular Filtration Rate Estimation in Prospective Living Kidney Donors: Preliminary Study

Gozdowska

Urbanowicz

Sadowska

et al. 2014

Transplantation Proceedings

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Section: Discussionmentioning

confidence: 99%

Glomerular Filtration Rate Estimation in Prospective Living Kidney Donors: Preliminary Study

Gozdowska

Urbanowicz

Sadowska

et al. 2014

Transplantation Proceedings

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“…All these formulae lack the proper validation at the GFR at which they were applied because the creatinine methods were not standardized among the intervening centers, giving rise to differences in creatinine measurements [2, 4]. Finally, creatinine-based estimations of GFR present many drawbacks and depend on many variables, and the precision of these equations remains under intense debate [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

“…Many equations based on creatinine and cystatin C have been developed. In this regard, we have recently published a prospective study in which kidney function was evaluated employing 99m Tc-DTPA as the gold standard of GFR and creatinine or cystatin C equations [6]. In that manuscript in which 300 subjects were included the main conclusions were that at GFR < 60 mL/min, CKD-EPI creatinine and cystatin C-based Hoek equations gave the best correlations with 99m Tc-DTPA.…”

Section: Introductionmentioning

confidence: 99%

Proteinuria, ^99mTc-DTPA Scintigraphy, Creatinine-, Cystatin- and Combined-Based Equations in the Assessment of Chronic Kidney Disease

et al. 2014

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Background. Precise estimation of the glomerular filtration rate (GFR) and the identification of markers of progression are important. We compared creatinine, cystatin, and combined CKD-EPI equations with 99mTc-DTPA scintigraphy to measure GFR and proteinuria as markers of progression. Methods. Cross-sectional, observational study including 300 subjects. CKD was classified by 99mTc-DTPA scintigraphy. Determinations. Creatinine, 24-hour creatinine clearance, cystatin, Hoek formula, and creatinine, cystatin, and combined CKD-EPI equations. Results. In the global assessment, creatinine CKD-EPI and combined CKD-EPI equations yielded the highest correlations with 99mTc-DTPA: ρ = 0.839, P < 0.0001 and ρ = 0.831, P < 0.0001. Intergroup analysis versus 99mTc-DTPA: control G, creatinine clearance ρ = 0.414, P = 0.013; G3, combined CKD-EPI ρ = 0.5317, P < 0.0001; G4, Hoek ρ = 0.618, P < 0.0001, combined CKD-EPI ρ = 0.4638, P < 0.0001; and G5, creatinine clearance ρ = 0.5414, P < 0.0001, combined CKD-EPI ρ = 0.5288, P < 0.0001. In the global assessment, proteinuria displayed the highest significant correlations with cystatin (ρ = 0.5433, P < 0.0001) and cystatin-based equations (Hoek: ρ = −0.5309, P < 0.0001). When GFR < 60 mL/min: in stage 3, proteinuria-cystatin (ρ = 0.4341, P < 0.0001); proteinuria-Hoek (ρ = −0.4105, P < 0.0001); in stage 4, proteinuria-cystatin (ρ = 0.4877, P < 0.0001); proteinuria-Hoek (ρ = −0.4877, P = 0.0026). Conclusions. At every stage of GFR < 60 mL/min, cystatin-based equations displayed better correlations with 99mTc-DTPA. Proteinuria and cystatin-based equations showed strong associations and high degrees of correlation.

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“…In early stage renal failure patients and healthy population, statistical significance was found to be continuing with declining correlation (r ¼ 0.60, P50.001). 30 In a study Huang and colleagues have made in a heterogeneous group of 42 adult patients, they compared Filler, Grubb, Hoek, Larsson, Le Bricon ve Rule formulas with multiple blood sampling method using Tc-99m DTPA. They found that Cystatin-C based formulas showed a quite good correlation among themselves and that correlation coefficients with radionuclidic method changed between 0.87 and 0.65 (each P50.001).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Cystatin-C and radionuclidic measurement method of glomerular filtration rate in patients with lung cancer receiving cisplatin treatment

Öç¹,

Demır²,

Çekmen

et al. 2014

Renal Failure

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Objective: Cisplatin is a chemotherapeutic agent which affects renal functions adversely. The best indicator of renal functions is glomerular filtration rate (GFR) measurement. Cystatin-C appears to be a good alternative to existing methods of measuring GFR. However, it is controversial whether Cystatin-C demonstrates GFR correctly for patients receiving chemotherapy. This study aimed to investigate the correlation between GFR values calculated by Cystatin-C based formulas, radionuclidic method (multiple blood sampling) and blood Cystatin-C values in patients with lung cancer, receiving cisplatin treatment in both pre-treatment and post-treatment periods. Materials and methods: Thirty-six patients with lung cancer who were going to receive cisplatin treatment were included in this study. However, the evaluation was performed with 20 patients since 16 of them could not complete the treatment. Blood Cystatin-C values, GFR values calculated via Cystatin-C based formulas, and radionuclidic method were investigated before and after the cisplatin treatment. Results: After treatment significant decreases were detected in GFR values, obtained via radionuclidic measuring method. However, there was no significant difference in Cystatin-C values between pretreatment and post-treatment periods. Also GFR values obtained by Cystatin-C based formulas were not significantly different in pre-treatment and post-treatment periods. There were meaningful correlations between radionuclidic method and Cystatin-C values and Cystatin-C based formulas before treatment. However, all correlations disappeared after the treatment. Conclusion: GFR values, calculated by Cystatin-C may not be reliable in following renal functions in patients receiving chemotherapy. When reliable monitoring of the renal functions is necessary radionuclidic method may be preferred in these patients.

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Creatinine- vs. cystatin C-based equations compared with 99mTcDTPA scintigraphy to assess glomerular filtration rate in chronic kidney disease

Abstract: At GFR <60 ml/min, CKD-EPI and Hoek equations appeared to best correlate with (99m)TcDTPA. In controls and at early stages of CKD, creatinine-based equations correlated better with (99m)Tc-DTPA, with CKD-EPI being the one with the best degree of agreement.

Cited by 29 publications

References 37 publications

Glomerular Filtration Rate Estimation in Prospective Living Kidney Donors: Preliminary Study

Glomerular Filtration Rate Estimation in Prospective Living Kidney Donors: Preliminary Study

Proteinuria, ^99mTc-DTPA Scintigraphy, Creatinine-, Cystatin- and Combined-Based Equations in the Assessment of Chronic Kidney Disease

Correlation of Cystatin-C and radionuclidic measurement method of glomerular filtration rate in patients with lung cancer receiving cisplatin treatment

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Creatinine- vs. cystatin C-based equations compared with 99mTcDTPA scintigraphy to assess glomerular filtration rate in chronic kidney disease

Abstract: At GFR <60 ml/min, CKD-EPI and Hoek equations appeared to best correlate with (99m)TcDTPA. In controls and at early stages of CKD, creatinine-based equations correlated better with (99m)Tc-DTPA, with CKD-EPI being the one with the best degree of agreement.

Cited by 29 publications

References 37 publications

Glomerular Filtration Rate Estimation in Prospective Living Kidney Donors: Preliminary Study

Glomerular Filtration Rate Estimation in Prospective Living Kidney Donors: Preliminary Study

Proteinuria, 99mTc-DTPA Scintigraphy, Creatinine-, Cystatin- and Combined-Based Equations in the Assessment of Chronic Kidney Disease

Correlation of Cystatin-C and radionuclidic measurement method of glomerular filtration rate in patients with lung cancer receiving cisplatin treatment

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Proteinuria, ^99mTc-DTPA Scintigraphy, Creatinine-, Cystatin- and Combined-Based Equations in the Assessment of Chronic Kidney Disease