2021
DOI: 10.1016/j.yjmcc.2021.03.008
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Creld1 regulates myocardial development and function

Abstract: CRELD1 (Cysteine-Rich with EGF-Like Domains 1) is a risk gene for non-syndromic atrioventricular septal defects in human patients. In a mouse model, Creld1 has been shown to be essential for heart development, particularly in septum and valve formation. However, due to the embryonic lethality of global Creld1 knockout (KO) mice, its cell type-specific function during peri-and postnatal stages remains unknown.Here, we generated conditional Creld1 KO mice lacking Creld1 either in the endocardium (KO Tie2 ) or th… Show more

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Cited by 12 publications
(9 citation statements)
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“…Cysteine rich with epidermal growth factor like domains 1 ( CRELD1 ) is a multifunctional gene that mostly plays important roles in myocardial development ( Beckert et al, 2021 ) and immune system homeostasis ( Bonaguro et al, 2020 ). Most human fetal and adult tissues express CRELD1 and the gene expression in skeletal muscle and adult heart has a higher level ( Rupp et al, 2002 ).…”
Section: Introductionmentioning
confidence: 99%
“…Cysteine rich with epidermal growth factor like domains 1 ( CRELD1 ) is a multifunctional gene that mostly plays important roles in myocardial development ( Beckert et al, 2021 ) and immune system homeostasis ( Bonaguro et al, 2020 ). Most human fetal and adult tissues express CRELD1 and the gene expression in skeletal muscle and adult heart has a higher level ( Rupp et al, 2002 ).…”
Section: Introductionmentioning
confidence: 99%
“…Proteins of the Creld family [cysteine-rich with epithelial growth factor (EGF)–like domains] are ER proteins that have been reported to regulate ER stress response and untranslated protein response ( 23 , 24 ). CRELD1 is a risk gene for atrioventricular septal defects, and murine CRELD1 is required during heart development ( 25 ). A recent study links human CRELD1 to T cell survival ( 26 ).…”
Section: Introductionmentioning
confidence: 99%
“…1,4 We previously characterized the function of Creld1 as being essential for heart development and immune cell function in mice. [4][5][6] In contrast, Creld2 is localized predominantly within the endoplasmic reticulum (ER) and can be secreted. 3,7,8 Indeed, Creld2 has been suggested as a biomarker in human body fluids for molecular phenotyping of pathophysiologies such as kidney disease 9 and prosthetic joint infections.…”
Section: Introductionmentioning
confidence: 99%
“…Creld1 is found anchored in the plasma membrane facing the extracellular matrix 1,4 . We previously characterized the function of Creld1 as being essential for heart development and immune cell function in mice 4–6 . In contrast, Creld2 is localized predominantly within the endoplasmic reticulum (ER) and can be secreted 3,7,8 .…”
Section: Introductionmentioning
confidence: 99%