Crescimento e alterações no fígado e na carcaça de alevinos de jundiá alimentados com dietas com aflatoxinas

Lopes, Paulo Rodinei Soares; Neto, João Radünz; Mallmann, Carlos Augusto; Lazzari, Rafael; Pedron, Fabrício de Araújo; Veiverberg, Cátia Aline

doi:10.1590/s0100-204x2005001000012

Cited by 23 publications

(26 citation statements)

References 14 publications

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“…The effect of aflatoxins on the liver and immune system is well known, causing a great deal of damage to the metabolism of proteins, carbohydrates and lipids (Mallmann et al, 1994;Rosmaninho et al, 2001;Bennett;Klich, 2003). The fishes receiving aflatoxin become sensitive to stress due to environmental and microbial factors (Rosmaninho et al, 2001;Lopes et al, 2005). It is believed that the same may have occurred in our study, with reduced parameters of apparent feed conversion and total length.…”

Section: Discussionsupporting

confidence: 72%

“…Arana et al (2002) showed that the trout genotype can significantly affect the effect of aflatoxins on growth parameters and weight gain. The catfish is a resistant fish (Jantrarotai;Lovell, 1991), which was also confirmed by Lopes et al (2005) after evaluating the effect of aflatoxins on catfish. This indicates the importance of the impact of the species and intrinsic genetic components on the effects caused by micotoxins on fish, and this may explain some of the results described in this study.…”

Section: Discussionmentioning

confidence: 71%

“…Lopes et al (2005) observed a decrease in the growth of silver catfish fingerlings (Rhamdia quelen) fed on a diet containing aflatoxin at a concentration of 0.204 mg/kg, but no effect was observed on the survival of fishes even when doses of 1.177 mg/kg were administered.…”

Section: Discussionmentioning

confidence: 96%

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Aeromonas hydrophila in tilapia (Oreochromis niloticus) after the intake of aflatoxins

et al. 2013

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) e um grupo controle com ração sem aflatoxina, em um delineamento inteiramente randomizado com quatro tratamentos e cinco repetições. No segundo ensaio, utilizou-se um grupo controle que recebeu ração livre de aflatoxina, o qual foi inoculado com solução salina (grupo 1) e Aeromonas hydrophila (grupo 2), bem como grupos de animais que receberam ração contendo 0,350 mg.kg feed -1 de aflatoxina (grupo 3); 0,757 mg.kg feed -1 de aflatoxina (grupo 4); e 1,177 mg.kg ração -1 de aflatoxina (grupo 5), sendo estes grupos inoculados com Aeromonas hydrophila. A sobrevivência e o comprimento total dos alevinos foram influenciados pelos tratamentos (p < 0,05). A ação sinérgica de aflatoxinas e Aeromonas hydrophila mostrou-se eficaz ao provocar a morte dos alevinos e influenciar a conversão alimentar e comprimento. PALAVRAS-CHAVE:peixe; micotoxina; patógeno oportunista. ABSTRACT:The objectives of this study were to assess the effect of the intake of aflatoxin on the development of tilapia and to evaluate the impact of inoculation with Aeromonas hydrophila on performance parameters, so these two individual tests were performed. One hundred and twenty fingerlings aged 35 days old, with mean weight of 1.55 ± 0.005 g and mean length of 5 cm were used in each test, distributed in 20 tanks. Each experimental unit consisted of a 60 L tank with six fingerlings. In the first experiment, increasing levels of aflatoxin (0.350, 0.757, 1.177 mg.kg feed -1 ) were used as treatments and, for the control group, a diet without aflatoxin was used in a completely randomized design with four treatments and five replicates. In the second experiment, a control group of Nile tilapia fingerlings was used and received a diet without aflatoxin, inoculated with saline solution (group 1) and Aeromonas hydrophila (group 2), as well as groups of animals fed on diets containing 0.350 mg.kg feed -1 of aflatoxin (group 3), 0.757 mg.kg feed -1 of aflatoxin (group 4) and 1.177 mg.kg feed -1 of aflatoxin (group 5), and these groups were inoculated with Aeromonas hydrophila. The survival rate and the total length of fingerlings were influenced by the treatments (p < 0.05). The synergistic action of aflatoxins and Aeromonas hydrophila was effective and caused the death of experimental fish, thus affecting feed conversion and length.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 71%

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Aeromonas hydrophila in tilapia (Oreochromis niloticus) after the intake of aflatoxins

et al. 2013

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“…Além disso, observou-se também diminuição no ganho com o aumento dos níveis de adsorvente na dieta. Valores semelhantes também foram encontrados por Lopes et al (2005), de 0,23 g de ganho de peso médio diário, com ração controle para alevinos de jundiá em 45 dias experimentais. De certa forma, o peso corporal dos alevinos de jundiá foi proporcional ao crescimento (padrão e total), pois houve diferença significativa no fator de condição corporal, de modo que a ração controle, sem adsorvente, resultou em índice de 0,82, e, com a inclusão de aflatoxina, o fator de condição corporal baixou até valores de 0,72 (Tabela 3).…”

Section: Resultsunclassified

“…Diversos estudos comprovaram também que a bentonita sódica é um ótimo adsorvente para aflatoxinas em aves, do mesmo modo que as ASSCA (Mallmann et al, 2007).…”

Section: Introductionunclassified

Utilização de adsorvente em rações contendo aflatoxina para alevinos de jundiá

Lopes

Pouey

Enke³

et al. 2009

R. Bras. Zootec.

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RESUMO -Neste trabalho foi avaliado o efeito de um adsorvente (aluminossilicato de cálcio e sódio) no desempenho de alevinos de jundiá (Rhamdia quelen) alimentados com rações contendo níveis crescentes de aflatoxina. Foram utilizados 360 peixes com peso inicial de 4,2 ± 0,6 g, criados em sistema de recirculação da água termorregulada, durante 90 dias, e alimentados com rações contendo um dos quatro níveis de aflatoxinas (0, 150, 250 e 350 μg/kg), com e sem inclusão de adsorvente (0, 0,3 e 0,6%), com três repetições. O uso de aflatoxina teve efeito negativo sobre o crescimento e o ganho de peso dos alevinos, que reduziram proporcionalmente aos níveis de aflatoxina, mas não ocasionou mortalidade. Os níveis de adsorvente na dieta não diminuíram os efeitos das aflatoxinas no desempenho dos peixes, mas diminuíram a aceitação da ração, em virtude da palatabilidade do produto. Não é recomendável a utilização de aluminossilicato de cálcio e sódio como adsorvente de aflatoxinas em rações para alevinos de jundiá. Palavra-chave: aluminossilicato, micotoxina, nutrição, toxinaUse of adsorbent in diets containing aflatoxin for silver catfish fingerlings ABSTRACT -The effects of aflatoxins and one adsorbent (Sodium and calcium aluminum silicate) on silver catfish (Rhamdia quelen) fingerlings were evaluated in this study. Three hundred and sixty fish, with initial weight of 4 g, were raised in a thermo-regulated recirculation water system, during 90 days. Twelve treatments with four aflatoxin levels in diet (0, 150, 250 and 350 μg/kg), with and without adsorbents (0, 0.3 and 0.6%) were tested in three replications. The results showed that the negative effect of aflatoxins significantly reduced the growth and weight gain of fingerlings, proportionately to the increasing levels of aflatoxin in diet, with mortality occurrence. The adsorbent levels in diet did not diminish the effects of aflatoxin action on fish performance due to the low inclusion and also little acceptance of ration in relation to the product palatability. It is concluded that silver catfish fingerlings fed diets containing aflatoxin are susceptible to negative effects, with high losses in growth and weight gain.Key Words: aluminum silicate, micotoxin, nutrition, toxin IntroduçãoOs custos com alimentação na aqüicultura determinam grande parte dos custos totais de produção nas criações semi-intensivas (Meer et al., 1995), uma vez que as dietas para peixes possuem elevado teor de proteína em comparação às dietas para outros animais cultivados (Furuya et al., 1997). Assim, na aquisição de ingredientes com alto padrão de qualidade nutricional para elaboração de dietas para os peixes, devem ser considerados principalmente os níveis de micotoxinas.As micotoxinas são metabólitos tóxicos secundários, produzidos por fungos do gênero Aspergillus, espécies A. flavus e A. parasiticus (Yu et al., 2005), que contaminam alguns ingredientes utilizados em rações desde a cultura no campo até o armazenamento nos silos. As micotoxinas apresentam, de modo geral, grande estabilidade q...

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Changes in the cerebral phosphotransfer network impair energetic homeostasis in an aflatoxin B1-contaminated diet

Baldissera

Souza

Zeppenfeld

et al. 2018

Fish Physiol Biochem

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The phosphotransfer network system, through the enzymes creatine kinase (CK), adenylate kinase (AK), and pyruvate kinase (PK), contributes to efficient intracellular energetic communication between cellular adenosine triphosphate (ATP) consumption and production in tissues with high energetic demand, such as cerebral tissue. Thus, the aim of this study was to evaluate whether aflatoxin B (AFB) intoxication in diet negatively affects the cerebral phosphotransfer network related to impairment of cerebral ATP levels in silver catfish (Rhamdia quelen). Brain cytosolic CK activity decreased in animals fed with a diet contaminated with AFB on days 14 and 21 post-feeding, while mitochondrial CK activity increased, when compared to the control group (basal diet). Also, cerebral AK and PK activity decreased in animals fed with a diet contaminated with AFB on days 14 and 21 post-feeding, similarly to the results observed for cerebral ATP levels. Based on this evidence, inhibition of cerebral cytosolic CK activity is compensated by stimulation of mitochondrial CK activity in an attempt to prevent impairment of communication between sites of ATP generation and ATP utilization. The inhibition of cerebral AK and PK activity leads to impairment of cerebral energy homeostasis, decreasing the brain's ATP availability. Moreover, the absence of a reciprocal compensatory mechanism between these enzymes contributes to cerebral energetic imbalance, which may contribute to disease pathophysiology.

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Crescimento e alterações no fígado e na carcaça de alevinos de jundiá alimentados com dietas com aflatoxinas

Cited by 23 publications

References 14 publications

Aeromonas hydrophila in tilapia (Oreochromis niloticus) after the intake of aflatoxins

Aeromonas hydrophila in tilapia (Oreochromis niloticus) after the intake of aflatoxins

Utilização de adsorvente em rações contendo aflatoxina para alevinos de jundiá

Changes in the cerebral phosphotransfer network impair energetic homeostasis in an aflatoxin B1-contaminated diet

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