cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer

Liang, Xiaomei; Yang, Yulu; Huang, Chengzhi; Ye, Zhibin; Lai, Wujiang; Luo, Jiamao; Li, Xiaoxuan; Yi, Xin; Fan, Jun‐Bing; Wang, Ying; Wang, Yifeng

doi:10.1016/j.jconrel.2023.03.017

Cited by 17 publications

(5 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanocarriers have also been used to specifically target to tumors, such as the tumor-targeted probes for Follicle-stimulating hormone (Liu et al, 2024). Furthermore, multifunctional nanoparticles (DDP-Ola@HR) which were loaded with both DDP and Olaparib and modified with heparin, have shown effectiveness in inhibiting the growth and metastasis of DDP-resistant OC (Liang et al, 2023). However, there are challenges that need to be addressed.…”

Section: Discussionmentioning

confidence: 99%

Current trends and emerging patterns in the application of nanomaterials for ovarian cancer research: a bibliometric analysis

Wang,

Wei,

Feng

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Introduction: Ovarian cancer remains to be a significant cause of global cancer-related mortality. In recent years, there has been a surge of studies in investigating the application of nanomaterials in the diagnosis and treatment of ovarian cancer. This study aims to conduct a comprehensive bibliometric analysis regarding nanomaterial-based researches on ovarian cancer to evaluate the current state and emerging patterns in this field.Methods: A thorough literature search on the Web of Science Core Collection database was conducted to identify articles focused on nanomaterial-based ovarian cancer researches. The studies that met the inclusion criteria were selected for further analysis. VOSviewer and CiteSpace were applied for the bibliometric and visual analyses of the selected publications.Results: A total of 2,426 studies were included in this study. The number of annual publications showed a consistent upward trend from 2003 to 2023. Notably, China, the United States, and India have emerged as the leading contributors in this field, accounting for 37.39%, 34.04%, and 5.69% of the publications, respectively. The Chinese Academy of Sciences and Anil K. Sood were identified as the most influential institution and author, respectively. Furthermore, the International Journal of Nanomedicine was the most frequently cited journal. In terms of the research focus, significant attention has been directed towards nanomaterial-related drug delivery, while the exploration of immunogenic cell death and metal-organic frameworks represented recent areas of interest.Conclusion: Through comprehensive analyses, an overview of current research trends and emerging areas of interest regarding the application of nanomaterials in ovarian cancer was illustrated. These findings offered valuable insights into the status and future directions of this dynamic field.

show abstract

Section: Discussionmentioning

confidence: 99%

Current trends and emerging patterns in the application of nanomaterials for ovarian cancer research: a bibliometric analysis

Wang,

Wei,

Feng

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…However, the cancer cells stimulate the alternative molecular pathways to stimulate resistance into these therapies. The increasing evidences have shown that nanostructures can improve the ability of conventional therapies in cancer suppression, they reverse drug resistance and augment immunotherapy [ 173 – 176 ]. Since Wnt has been associated with EMT induction, the application of nanoparticles for the regulation of Wnt/EMT axis has been provided.…”

Section: Nanoparticle-mediated Regulation Of Wnt/emt Axis In Cancer M...mentioning

confidence: 99%

Wnt/β-catenin-driven EMT regulation in human cancers

Xue,

Yang,

Chen

et al. 2024

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Metastasis accounts for 90% of cancer-related deaths among the patients. The transformation of epithelial cells into mesenchymal cells with molecular alterations can occur during epithelial–mesenchymal transition (EMT). The EMT mechanism accelerates the cancer metastasis and drug resistance ability in human cancers. Among the different regulators of EMT, Wnt/β-catenin axis has been emerged as a versatile modulator. Wnt is in active form in physiological condition due to the function of GSK-3β that destructs β-catenin, while ligand–receptor interaction impairs GSK-3β function to increase β-catenin stability and promote its nuclear transfer. Regarding the oncogenic function of Wnt/β-catenin, its upregulation occurs in human cancers and it can accelerate EMT-mediated metastasis and drug resistance. The stimulation of Wnt by binding Wnt ligands into Frizzled receptors can enhance β-catenin accumulation in cytoplasm that stimulates EMT and related genes upon nuclear translocation. Wnt/β-catenin/EMT axis has been implicated in augmenting metastasis of both solid and hematological tumors. The Wnt/EMT-mediated cancer metastasis promotes the malignant behavior of tumor cells, causing therapy resistance. The Wnt/β-catenin/EMT axis can be modulated by upstream mediators in which non-coding RNAs are main regulators. Moreover, pharmacological intervention, mainly using phytochemicals, suppresses Wnt/EMT axis in metastasis suppression. Graphical abstract

show abstract

“…The stimuliresponsive drug release system can be incorporated into these targeted nanoparticles to further enhance their efficacy. 187 This system allows for the controlled release of therapeutic agents in response to specific stimuli, such as changes in pH, temperature, or the presence of certain enzymes ensuring that the drugs are only released at the desired location and time. Additionally, this targeted drug delivery approach has shown promising results in preclinical studies, highlighting its potential as a future treatment option for ovarian cancer.…”

Section: Nanotechnology Advances For Gestational Trophoblastic Disord...mentioning

confidence: 99%

“…In which, the generic nanoparticles are modified with these targeting molecules or antibodies to specifically deliver therapeutic agents to cancer stem cells. The stimuli-responsive drug release system can be incorporated into these targeted nanoparticles to further enhance their efficacy . This system allows for the controlled release of therapeutic agents in response to specific stimuli, such as changes in pH, temperature, or the presence of certain enzymes ensuring that the drugs are only released at the desired location and time.…”

Section: Applications Of Nanotechnology-mediated Drug Delivery System...mentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Acharya,

Behera,

Behera

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important in reproductive health care, which has become an emerging and significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, and reproductive cancers. Nanotechnology presents promising solutions to address these concerns by introducing innovative tools and techniques, facilitating early detection, targeted drug delivery, and improved imaging capabilities. Through the utilization of nanoscale materials and devices, researchers can craft treatments that are not only more precise but also more effective, significantly enhancing outcomes in reproductive healthcare. Looking forward, the future of nanotechnology in reproductive medicine holds immense potential for reshaping diagnostics, personalized therapies, and fertility preservation. The utilization of nanotechnology-driven drug delivery systems is anticipated to elevate treatment effectiveness, minimize side effects, and offer patients therapies that are not only more precise but also more efficient. This review aims to delve into the various types, properties, and preparation techniques of nanocarriers specifically designed for drug delivery in the context of reproductive disorders, shedding light on the current landscape and potential future directions in this dynamic field.

show abstract

cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer

Cited by 17 publications

References 44 publications

Current trends and emerging patterns in the application of nanomaterials for ovarian cancer research: a bibliometric analysis

Current trends and emerging patterns in the application of nanomaterials for ovarian cancer research: a bibliometric analysis

Wnt/β-catenin-driven EMT regulation in human cancers

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Contact Info

Product

Resources

About