Crimean-Congo hemorrhagic fever and expansion from endemic regions

Spengler, Jessica R.; Bergeron, Éric; Spiropoulou, Christina F.

doi:10.1016/j.coviro.2018.12.002

Cited by 108 publications

(96 citation statements)

References 77 publications

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“…Saksida et al [9], Hasanoğlu et al [7] and Yilmaz et al [10] reported the mortality rate associated with CCHF to be 27.5%, 8.1%, and 5%, respectively. The mortality rate was reported to be lower in countries such as Turkey and Russia, where CCHF is endemic, but the underlying reasons have not yet been elucidated [5,6]. In agreement with findings in the literature, the mortality rate was found to be 8.1% in the present study.…”

Section: Discussionsupporting

confidence: 90%

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Factors affecting mortality in Crimean-Congo hemorrhagic fever

Kavak¹,

Gürbüz²

2019

Journal of Surgery and Medicine

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This is an open access article distributed under the terms of the CreativeCommons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Crimean-Congo hemorrhagic fever is a viral disease that is transmitted by infected ticks and has high mortality.We aim to determine the factors affecting mortality in patients with Crimean-Congo hemorrhagic fever (CCHF). Methods: Age, gender, number of ticks, tick removal procedures, tick location, time to hospital admission, symptoms, physical examination findings, vital signs, laboratory parameters and factors affecting mortality were evaluated. The study was designed as a retrospective cohort study. Results: The median age of the 172 patients was 46 (range, 18-78) years, and 73.8% of the patients were men. The mortality rate was high in patients with delayed time to hospital admission, those who were bitten on the head and neck region, those who had a high number of tick bites, those who had removed the tick themselves or had the tick removed by a relative and those who had impaired consciousness (P=0.001, P<0.001, P<0.001, P<0.001 and P=0.002, respectively). Bleeding was detected in 87.2% of cases. The frequency of ecchymosis, pleural effusion, hematuria, hematemesis and melena occurrence was high in non-survivors (P<0.001, P<0.001, P<0.001, P=0.006 and P=0.006, respectively). Fever and heart rate were significantly higher, systolic and diastolic blood pressure was significantly lower in non-survivors (P<0.001, P<0.001, P=0.006 and P<0.001, respectively). Additionally, the white blood cell (WBC) count, international normalized ratio (INR), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly higher and platelet count were significantly lower in non-survivors (P<0.001 for all). Conclusion: We found that in patients with CCHF, bleeding was a major factor associated with mortality. Factors such as a number of ticks, the number of people removing the ticks and tick location were found to affect mortality. We believe that blood tests and vital parameters can be used to predict mortality in patients with CCHF. Öz Amaç: Kırım kongo kanamalı ateşi enfekte kenelerle bulaşan ve yüksek mortaliteye sahip viral bir hastalıktır. Kırım Kongo Kanamalı Ateşi (KKKA) hastalarında mortalite üzerinde etkili faktörleri belirlemeyi amaçladık. Yöntemler: Hastaların yaş, cinsiyet, kene teması, kene sayısı, kenenin kim tarafından çıkarıldığı, kenenin vücuttaki lokalizasyonu, hastaneye başvuru süresi, semptomları, fizik muayene ve vital bulguları, laboratuvar parametreleri ve mortaliteye etki eden faktörler değerlendirildi. Çalışma retrospektif kohort olarak dizayn edildi. Bulgular: 172 hastanın yaş ortancası 46 (18-78) yıl olup, olguların %73,8'i erkekti. Hastaneye başvurusu geç olan, baş ve boyun bölgesinden ısırılmış olan, ısıran kene sayısı fazl...

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Section: Discussionsupporting

confidence: 90%

“…The mortality rate associated with this disease is 5%-30%; however, the mortality rate is lower in endemic regions such as Turkey and Russia. It remains unclear whether the differences in mortality are related to regional differences or case management strategies [5,6].…”

Section: Introductionmentioning

confidence: 99%

Factors affecting mortality in Crimean-Congo hemorrhagic fever

Kavak¹,

Gürbüz²

2019

Journal of Surgery and Medicine

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“…Fatality rates range from ~5% to −80% in different countries. A relatively low fatality rate (4.6%) has been reported from the most recent Turkish series compared to reports from other countries 1 . CCHF causes both disease‐related morbidity and mortality and economic losses with the increase in the number of cases reported in the world.…”

Section: Introductionmentioning

confidence: 84%

Association of MCP‐1 promotor polymorphism with disease severity of Crimean‐Congo hemorrhagic fever

Bağcı

Bağci

Büyüktuna

et al. 2020

Journal of Medical Virology

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Crimean‐Congo hemorrhagic fever (CCHF) is a thick‐borne viral zoonotic disease. The pathogenesis and the reasons why cases have a mild or severe course in CCHF have not yet been explained. In this study, we investigated the relationship between promoter ‐2518 A/G single‐nucleotide polymorphism (SNP) of the MCP‐1 gene and the clinical course of CCHF. The MCP‐1‐2518 A/G SNP (rs1024611) frequency was examined in 128 virologically/serologically confirmed CCHF patients and 181 healthy controls by using the PCR‐RFLP method. When CCHF patients and controls were compared, no significant difference was found between genotype distributions and allele frequencies of the ‐2518 A/G SNP of MCP‐1 gene (P > .05). Compared to the AA genotype, both AG (P = .016; OR = 2.57) and GG genotype (P = .039; OR = 3.43) were found with significantly higher frequencies in mild/moderate cases than in severe cases. Compared to the AG + GG genotype, AA showed a significant risk for severe CCHF (60.0% vs 38.4%, P = .02; OR = 2.41). In contrast, the AG genotype showed a significant protective effect against severe disease compared to AA + GG genotype (29.1% vs 47.9%, P = .013; OR = 2.58). Compared to mild/moderate cases, the A allele was found to be significantly higher in severe cases (0.745 vs 0.623, P = .039; OR = 1.77). However, no significant relationship was found between fatal and nonfatal cases in terms of genotype or allele frequencies (P > .05). In conclusion, both ‐2518 AA genotype and A allele of MCP‐1 were associated with disease severity, and the AG genotype had a protective effect against a severe disease course in CCHF patients.

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“…In particular, the climate change along with anthropogenic factors may have caused significant effect on reproduction rate of Hyalomma tick. This inevitably resulted in extensive amplification of virus through tick vertebra tick cycle (along with increase of wildlife population) [20,[43][44][45] . Owing to security reasons, several activities including, agriculture, farming, and hunting were limited in the rural areas in Tokat and neighbouring provinces between 1995 and 2001.…”

Section: Emergence Of Crimean Congo Haemorrhagic Fever Disease In Turkeymentioning

confidence: 99%

“…This is particularly important to map areas where outbreaks could occur in future and to alert public health systems. If the prevalence of CCHFV increases in ticks, in conjunction with virus specific antibody circulation in wild and domestic animals in any given area, cases of disease outbreak may occur [9,44,45] . These examples highlight the importance of veterinary medicine in the one health initiative, particularly in case of CCHFV disease.…”

Section: One Health Initiative To Combat Cchf Diseasementioning

confidence: 99%

Türkiye’de Kırım Kongo Kanamalı Ateşi Hastalığının Güncel ve Gelecekteki Etkileri

Kalaycioğlu¹

2019

Kafkas Univ Vet Fak Derg

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Crimean-Congo haemorrhagic fever virus (CCHFV) is an emerging tick-borne zoonosis and a public health concern in Turkey since its first confirmation in 2002. The virus displays great genetic diversity and tends to expand its release to new areas. The presence of the biological tick vectors harbouring the virus and a suitable habitat are the predisposing factors for disease emergence in Turkey and elsewhere. As Turkey is one of the most endemic countries for CCHF disease, deliberate studies should be conducted to monitor all aspects of virus circulation and diversity in all endemic and non-endemic areas of the country. This will help to gain valuable information to predict the fate of the disease, and to develop effective vaccines and treatment facilities. Owing to the zoonotic nature of the virus, it offers a good prospect for collaboration of human and veterinary medicine with the view to fight the disease based on the one health initiative. This review was focussed on CCHFV diversity, perspectives of disease occurrence in Turkey, and the present and future implications of the disease.

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Crimean-Congo hemorrhagic fever and expansion from endemic regions

Cited by 108 publications

References 77 publications

Factors affecting mortality in Crimean-Congo hemorrhagic fever

Factors affecting mortality in Crimean-Congo hemorrhagic fever

Association of MCP‐1 promotor polymorphism with disease severity of Crimean‐Congo hemorrhagic fever

Türkiye’de Kırım Kongo Kanamalı Ateşi Hastalığının Güncel ve Gelecekteki Etkileri

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