2023
DOI: 10.3390/ph16070920
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CRISPR-Based Gene Editing in Acinetobacter baumannii to Combat Antimicrobial Resistance

Abstract: Antimicrobial resistance (AMR) poses a significant threat to the health, social, environment, and economic sectors on a global scale and requires serious attention to addressing this issue. Acinetobacter baumannii was given top priority among infectious bacteria because of its extensive resistance to nearly all antibiotic classes and treatment options. Carbapenem-resistant A. baumannii is classified as one of the critical-priority pathogens on the World Health Organization (WHO) priority list of antibiotic-res… Show more

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Cited by 8 publications
(3 citation statements)
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“…In this context, the innovative use of CRISPR-Cas9 technology allowed for the design of phages by modifying the tail protein gene sequence. This modification increases the phage's efficacy and specificity in targeting bacterial cells during lysis [115].…”
Section: Bacteriophage Therapymentioning
confidence: 99%
“…In this context, the innovative use of CRISPR-Cas9 technology allowed for the design of phages by modifying the tail protein gene sequence. This modification increases the phage's efficacy and specificity in targeting bacterial cells during lysis [115].…”
Section: Bacteriophage Therapymentioning
confidence: 99%
“…Each CRISPR/Cas system has a specific protein composition for expression, interference, and adaptation [ 394 , 395 , 400 ]. Class 1 comprises three types (I, III, and IV) and sixteen subtypes, whereas Class 2 includes three types (II, V, and VI) and seventeen subtypes [ 401 , 402 ]. The Class 1 CRISPR/Cas system takes on interference through the use of a multi-Cas effector protein complex, whereas Class 2 utilises a single effector protein responsible for the identification and cleavage of the target sequence [ 403 ].…”
Section: Qs Pathways Inhibitionmentioning
confidence: 99%
“…The invention and use of antimicrobial agents and antibiotics have lowered the morbidity and lethality of infectious diseases caused by microorganisms in humans. Unfortunately, many broad-spectrum antibiotics clinically used to prevent and control infections have been misused over time, resulting in the emergence of drug-resistant pathogens [2]. Therefore, antibiotic-free, broad-spectrum, and highly efficient antibacterial materials are urgently required.…”
Section: Introductionmentioning
confidence: 99%