CRISPR editing in the lung with novel lipids

Abstract

CRISPR RNA is delivered to the mouse lung by inhalation using improved lipid nanoparticles.

Cavitation is the determining mechanism for the atomization of high-viscosity liquid

“…Gene therapy has become the development trend of modern medicine, 39 , 40 , 41 , 42 , 43 and inhaled gene therapy is the current research area in the field of inhaled medication delivery. 44 , 45 , 46 Under the single-dimensional energy supply, achieving a high energy supply that is necessary for the atomization of high-viscosity liquids is difficult. Therefore, the currently used piezoelectric ultrasonic atomizer cannot atomize the liquid with a viscosity higher than 10 cP, which results in that most medications used for inhaled therapy are primarily aqueous.…”