Critical Flicker Frequency After Small Doses of Methohexitone, Diazepam and Sodium 4-Hydroxybutyrate

Grove-White, I.G.; Kelman, G. R.

doi:10.1093/bja/43.2.110

Cited by 33 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of diazepam on the psychomotor variables measured are also parallel to those obtained by Borland & Nicholson (1975), Grove-White & Kelman (1971), Haffner, Morland, Setekleiv, Stromsaether, Danielsen, Frivik & Dybing (1973) and Morland, Setekleiv, Haffner, Stromaether, Danielsen & Holst Wethe (1974) on healthy volunteers. In the proprioceptive tests there was recorded a slight exaggeration after diazepam which effect was similar to that found after bromazepam (Saario, 1975).…”

Section: Discussionsupporting

confidence: 78%

Modification by diazepam or thioridazine of the psychomotor skills related to driving: a subacute trial in neurotic out‐patients.

Saario¹,

Linnoila²,

Mattila³

1976

Brit J Clinical Pharma

View full text Add to dashboard Cite

1Forty-five out-patients with clinically manifested anxiety were tested in order to study the effects of 2 weeks' treatment with placebo, diazepam (5-10 mg three times daily) or thioridazine (25-50 mg three times daily) on their psychomotor skills related to driving. 2 When compared with placebo, diazepam increased the number of mistakes in reaction and co-ordination tests and also decreased.ability to discriminate the fusion of flickering light.3 When compared to other groups, reactive and co-ordinative skills were more impaired in patients treated with thioridazine which also impaired divided attention. 4 Subjectively thioridazine was not experienced as effective an anxiolytic as diazepam.

show abstract

Section: Discussionsupporting

confidence: 78%

Modification by diazepam or thioridazine of the psychomotor skills related to driving: a subacute trial in neurotic out‐patients.

Saario¹,

Linnoila²,

Mattila³

1976

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…The doses of sodium oxybate that were examined in the present study (1.125–4.5 g/70 kg) are larger than those that have been administered in other studies that have examined cognitive effects of sodium oxybate in individuals without a history of drug abuse (e.g., Grove-White and Kelman 1971a, b; Mattila et al 1978; Ferrara et al 1999). The doses of sodium oxybate examined in this study resulted in relatively high participant ratings of subjective “drug effect,” which were comparable to those observed after the doses of triazolam that were examined (Fig.…”

Section: Discussionmentioning

confidence: 74%

“…Thus, GHB/sodium oxybate has been studied extensively in clinical trials for the treatment of cataplexy and excessive daytime sleepiness in narcolepsy (Xyrem Prescribing Information 2009). Experimental studies in humans that have examined the effects of sodium oxybate on cognitive processes have typically not studied a broad range of doses of sodium oxybate (e.g., Grove-White and Kelman 1971a, b; Mattila et al 1978; Ferrara et al 1999; Abanades et al 2007), not studied large doses of sodium oxybate (e.g., Grove-White and Kelman 1971a, b; Mattila et al 1978; Ferrara et al 1999), or have not studied the effects of sodium oxybate on episodic memory (i.e., memory for a personally experienced event, associated with a specific spatial and temporal context, e.g., Grove-White and Kelman 1971a; Mattila et al 1978; Ferrara et al 1999; Abanades et al 2006, 2007). However, there are some data that sodium oxybate can impair working memory (i.e., short-term memory that enables the temporary maintenance and on-line manipulation of information in the service of behavioral goals, e.g., Grove-White and Kelman 1971b) and episodic memory encoding processes (i.e., processes that are engaged during an event and lead to the creation of a representation or trace of the event) in humans (e.g., Carter et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers

2009

View full text Add to dashboard Cite

Rationale Illicit gamma-hydroxybutyrate (GHB) has received attention as a “date rape drug” that produces robust amnesia; however, there is little experimental evidence in support of GHB’s amnestic effects. Objectives This study compared the cognitive effects of GHB (sodium oxybate) with those of triazolam in healthy volunteers. Materials and methods Doses of sodium oxybate (1.125, 2.25, and 4.5 g/70 kg), triazolam (0.125, 0.25, and 0.5 mg/70 kg), and placebo were administered to 15 volunteers under repeated measures, counterbalanced, double-blind, double-dummy conditions. The time course and peak physiological, psychomotor, subjective, and cognitive effects were examined. Results Sodium oxybate and triazolam produced similar increases in participant ratings of drug effects. Performance on psychomotor, working memory, and episodic memory tasks was impaired to a greater extent after triazolam than sodium oxybate. Conclusions Together, these data suggest that sodium oxybate produces less psychomotor and cognitive impairment than triazolam at doses that produce equivalent participant-rated subjective effects in healthy volunteers.

show abstract

“…Complex psychomotor tests like reaction times to visual and auditory stimuli and especially the flicker fusion frequency have been established as very sensitive parameters for the persisting effects of anaesthesia in adults (14,15). This is the first time these tests were adapted to children and their suitability for this age group was demonstrated by a group of healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Recovery of psychomotor function following general anaesthesia in children: a comparison of propofol and thiopentone/halothane

Schröter

Motsch

Hufnagel

et al. 1996

Pediatric Anesthesia

View full text Add to dashboard Cite

The present study was undertaken to compare immediate recovery and recovery of complex psychomotor function in 20 children (aged 6-12 years) following general anaesthesia with either thiopentone/halothane or propofol. Early recovery of psychomotor skills was significantly faster in the propofol group than in the thiopentone/halothane group. Compared to preanaesthesia baseline the sedation and cooperation scores, the reaction time to visual and auditory stimuli as well as the postbox test and the flicker fusion frequency were less impaired after propofol than after thiopentone/halothane anaesthesia up to 120 min postoperatively. In the propofol group most tests reached preanaesthesia levels after 120 min, while in the thiopentone/halothane group these levels were not reattained throughout the entire study period. The results indicate that the recovery of psychomotor function in paediatric patients following general anaesthesia with propofol is significantly faster than with thiopentone/halothane. This has important implications for parental satisfaction, the time over which patients need to be monitored in the recovery room and for the discharge criteria after daycase surgery.

show abstract

Critical Flicker Frequency After Small Doses of Methohexitone, Diazepam and Sodium 4-Hydroxybutyrate

Cited by 33 publications

References 0 publications

Modification by diazepam or thioridazine of the psychomotor skills related to driving: a subacute trial in neurotic out‐patients.

Modification by diazepam or thioridazine of the psychomotor skills related to driving: a subacute trial in neurotic out‐patients.

Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers

Recovery of psychomotor function following general anaesthesia in children: a comparison of propofol and thiopentone/halothane

Contact Info

Product

Resources

About