Critical review on analytical detection of first line and second line anti tubercular agent by various modern analytical method

Abstract

Tuberculosis is a chronic inflammatory, granulomatous bacterial infectious disease caused by Mycobacterium tuberculosis. About 10 million people worldwide are ill with MTB in 2018, 5.7 million are males, 3.2 million are females and 1.1 million are infants, 1.6 million died from the disease. This article includes epidemiology, classification, pathogenesis, diagnosis and treatment of Tuberculosis. It includes the drug profile of antitubercular agents such as isoniazid, pyrazinamide, ethambutol, rifampicin, paraminosalicylic acid, thiacetazone, ethionamide, kanamycin, amikacin. cycloserine, viomycin, morphazinamide and some newer drugs such as ofloxacin, ciprofloxacin, clarithromycin and rifabutin. It contains analytical detection methods of antitubercular agents by HPLC.