Crocin averts functional and structural rat hepatic disturbances induced by copper oxide nanoparticles

Yousef, Doaa Mohammed; Hassan, Heba A.; Nafea, Ola Elsayed; Fattah, Eman Ramadan Abd El

doi:10.1093/toxres/tfac064

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…In this study, the elevation aminotransferases activities in vivo liver enzymes along with other biomarkers were used as indicators for CuO-NPs-induced rat intoxication. 38…”

Section: Copper Npsmentioning

confidence: 99%

The Interactions between Metallic Nanoparticles and Cytochrome P450, Alanine Aminotransferase, and Aspartate Aminotransferase Enzymes

Al-Btoush

2023

J. Pure Appl. Microbiol.

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The use of metallic nanoparticles (NPs) in various industrial and biomedical fields is increasing exponentially. As a result, research examining the potentially toxic impact of these NPs on human health is also increasing. Cytochrome P450 (P450s) enzymes are important for the endogenous and exogenous molecules metabolism. Inhibition or induction of these enzymes affects xenobiotic detoxification and causes clinically significant drug toxicity or therapeutic failures. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are the most frequently used biomarker for liver injury and their induction is an important indicator of hepatotoxicity. This review aims to understand the existing literature relevant to the effect of metallic NPs on P450s, ALT and AST (aminotransferases) enzymes. It was found that the predominant effect of metallic NPs is the inhibition of the CYP 450 gene and protein expression and induction of aminotransferases, which highlights their potential interaction and induction of drug-associated toxicity as well as their hepatotoxicity. However, further studies are recommended to investigate the effect of NPs size, morphology, surface area, charge, and NPs coating on the expression of these enzymes.

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“…In this study, the elevation aminotransferases activities in vivo liver enzymes along with other biomarkers were used as indicators for CuO-NPs-induced rat intoxication. 38…”

Section: Copper Npsmentioning

confidence: 99%

The Interactions between Metallic Nanoparticles and Cytochrome P450, Alanine Aminotransferase, and Aspartate Aminotransferase Enzymes

Al-Btoush

2023

J. Pure Appl. Microbiol.

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Preclinical Evaluation of Protective Effects of Terpenoids Against Nanomaterial‐Induced Toxicity: A Meta‐Analysis

Sun,

Zhou,

Xie

et al. 2024

J of Applied Toxicology

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Terpenoids, the largest class of natural products, have been demonstrated to confer antioxidant, anti‐inflammatory, anti‐apoptotic, and antitumor activities. However, whether terpenoids benefit populations exposed to nanomaterials through these mechanisms remains unclear. This meta‐analysis was to evaluate the effects of terpenoids in preclinical models with nanomaterial exposure. Electronic database searching identified 39 studies. The meta‐analysis by Stata 15.0 showed that terpenoid supplementation significantly improved cell viability and altered oxidative stress (decreased ROS, NO, MDA, and TOC and increased SOD, CAT, GPx, GSH, GSH‐Px, and TAC)–, inflammation (decreased IL‐6, IL‐1β, TNF‐α, NF‐κB, monocytes, and increased IL‐10)–, apoptosis (reduced Bax, caspase‐3, caspase‐9, P53, and elevated Bcl‐2)–, genotoxic (reduced tail length, % tail DNA, tail moment, DNA fragmentation, chromosomal aberration, and MNPCEs)–, liver function (reduced ALT, AST, and ALP)–, renal function (reduced creatinine, urea, and uric acid)–, reproductive function (increased sperm count, testosterone, Johnsen's score, and number of progeny)–, lipid profile (lower cholesterol, TG, LDL, and higher HDL)–, and carcinogenesis (downregulated AFP and CEA)–related biomarkers induced by nanomaterials. Subgroup analysis indicated that monoterpenoids and tetraterpenoids were particularly effective. Collectively, terpenoids may be a promising candidate for prevention of toxicities caused by nanomaterials.

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Moringa oleifera leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats

Hindawy,

Manawy,

Nafea

et al. 2024

Toxicology Research

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Background Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. Moringa oleifera (M. oleifera), known as a miracle tree, is utilized as a functional food and nutritional supplement. This study investigates the potential preventive effects of M. oleifera extract on aluminum chloride (AlCl3)-induced cortical neurodegeneration in rats. Materials and methods Therefore, 24 adult male Wistar rats were randomly divided into four distinct groups: negative control, M. oleifera extract (MOE), AlCl3, and AlCl3 + MOE. Treatments were administered orally for 28 consecutive days. Cognitive performance, brain oxidative/nitrosative stress, neuroinflammation, apoptotic-cell death, and associated histopathological alterations were assessed. Results Our results showed that MOE improved spatial learning and memory, enhanced antioxidant superoxide dismutase enzyme activity, antagonized nitrosative stress, reduced inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), decreased caspase-3, increased Bcl-2, and facilitated repair of cortical and hippocampal structures. Conclusions We concluded that MOE exhibits protective effects against cortical neurodegeneration, making it a promising supplement to counteract aluminum-induced neurotoxic effects.

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Crocin averts functional and structural rat hepatic disturbances induced by copper oxide nanoparticles

Cited by 3 publications

References 57 publications

The Interactions between Metallic Nanoparticles and Cytochrome P450, Alanine Aminotransferase, and Aspartate Aminotransferase Enzymes

The Interactions between Metallic Nanoparticles and Cytochrome P450, Alanine Aminotransferase, and Aspartate Aminotransferase Enzymes

Preclinical Evaluation of Protective Effects of Terpenoids Against Nanomaterial‐Induced Toxicity: A Meta‐Analysis

Moringa oleifera leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats

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