Crocin improved locomotor function and mechanical behavior in the rat model of contused spinal cord injury through decreasing calcitonin gene related peptide (CGRP)

Karami, Manizheh; Bathaie, S. Zahra; Tiraihi, Taki; Habibi-Rezaei, Mehran; Arabkheradmand, Jalil; Faghihzadeh, Soghrat

doi:10.1016/j.phymed.2013.07.013

Cited by 37 publications

(17 citation statements)

References 42 publications

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“…α‐Crocin (50, 100, and 200 mg/kg) prevented diazinon‐induced elevation of AST, ALT, ALP, LDH, CPK, creatine kinase‐MB and GGT, and other inflammatory biomarkers such as TNF‐α, 8‐iso‐prostaglandin F2a, and soluble protein‐100 β in rats serum (Hariri et al ., ). Crocins [crocins were extracted and purified according to a patented method for crocins purification (Bathaie, 2008)] also ameliorated locomotor function and mechanical behavior in a rat model of contused spinal cord injury via decreasing calcitonin gene‐related peptide , an important mediator of inflammation and pain (Karami et al ., ).…”

Section: Methodsmentioning

confidence: 97%

Antiinflammatory, Antioxidant, and Immunomodulatory Effects ofCrocus sativusL. and its Main Constituents

2016

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Crocus sativus L. (C. sativus), commonly known as saffron, is used as a food additive, preservative, and medicinal herb. Traditionally, it has been used as an alternative treatment for different diseases. C. sativus' medicinal effects are related to its major constituents like crocins, crocetin, and safranal. According to the literature, C. sativus and its constituents could be considered as an effective treatment for neurodegenerative disorders, coronary artery diseases, asthma, bronchitis, colds, fever, diabetes, and so on. Recently, numerous studies have reported such medicinal properties and found that the underlying mechanisms of action may be mediated by antioxidant, inflammatory, and immunomodulatory effects. C. sativus enhances the antioxidant capacity and acts as a free radical scavenger. As an antiinflammatory and immunomodulatory agent, it modulates inflammatory mediators, humoral immunity, and cell-mediated immunity responses. This review highlights in vitro and animal findings regarding antiinflammatory, antioxidant, and immunomodulatory effects of C. sativus and its constituents. Present review found that the C. sativus and its main constituents such as safranal, crocins, and crocetin could be effective against various diseases because of their antioxidant, anti-inflammation, and immunomodulatory effects. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Methodsmentioning

confidence: 97%

Antiinflammatory, Antioxidant, and Immunomodulatory Effects ofCrocus sativusL. and its Main Constituents

2016

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“…In addition, ER stress is an integral component of neuroinflammation and contributes to the development of neurological diseases. A decrease in the calcitonin gene-related peptide expression was also observed in these rats [106]. In primary human fetal astrocytes transfected with a Syncytin-1-expressing plasmid, XBP-1/s, BiP, and NOS2 were induced, which was suppressed by crocin treatment.…”

Section: Molecular Mechanisms Involved In the Protective Effect Of Samentioning

confidence: 64%

Anticancer Effect and Molecular Targets of Saffron Carotenoids

2014

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“…With regard to our present results and previous studies of cannabinoid receptors and their analgesic effects, it seems that the cannabinoid receptor is one of the possible mechanisms by which crocin exerts its analgesic effects. In addition, it should be noted that there are various mechanisms other than the cannabinoid system that play a role in the effects of crocin on the CCI-induced neuropathic pain, including the anti-inflammatory or antioxidative effect of crocin, 37,46,47 or the reducing effect of crocin on the CGRP level, 18 or the crocin-mediated release of analgesic mediators that needs to be further studied.…”

Section: Discussionmentioning

confidence: 99%

“…Someone believed that the mechanism of action of crocin in controlling neuropathic pain is a reduction in serum levels of CGRP. 18 The activity of cannabinoids and endocannabinoids in the CNS operate with specificity and occurs through interactions with CB1 receptors. 19 The CB1 receptors are widely distributed in the CNS and are predominantly present in the presynaptic terminals.…”

Section: Introductionmentioning

confidence: 99%

<p>Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats</p>

Vafaei¹,

Safakhah²,

Jafari³

et al. 2020

JEP

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Neuropathic pain involves injury or alteration of the normal sensory and modulatory nervous systems to produce a set of symptoms that are often difficult to treat. Previous study indicates that crocin has anti-inflammatory properties that may be mediated by the neurotransmitter system. In this study, we determine if there is an interaction between crocin and the cannabinoid system on chronic constriction injury (CCI)-induced neuropathic pain in male rats. Materials and Methods: In this experimental study, adult male Wistar rats (220-250 g) were used. CCI was induced by setting four loose ligatures around the sciatic nerve. In part 1, after nerve lesion, vehicle, crocin (60 mg/kg) or Win 55-212-2 (0.1 mg/kg) as an agonist and AM 251 (0.1 mg/kg) as an antagonist of cannabinoid receptors were injected intraperitoneally daily in separate groups for 2 weeks. In part 2, two weeks after nerve lesion, vehicle (5 µL), crocin (6 µg/5 µL), Win 55-212-2 (0.1 µg/5 µL), AM 251 (0.1 µg/5 µL) were administered intracerebroventricularly (ICV) in separate groups. Mechanical allodynia and thermal hyperalgesia were measured using Von Frey filaments and plantar test device, respectively, at day 14. Data were analyzed by two-way ANOVA and Sidak's multiple comparisons post-test. Results: Results indicated that centrally administered crocin significantly decreased thermal hyperalgesia and mechanical allodynia. Also, peripheral injection of crocin significantly decreased mechanical allodynia but not thermal hyperalgesia. Central or peripheral administration of Win 55-212-2 or AM 251 modulates the analgesic effect of crocin significantly. Conclusion: Our findings showed that crocin has significant analgesic effects that are probably mediated by an endocannabinoid mechanism.

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Crocin improved locomotor function and mechanical behavior in the rat model of contused spinal cord injury through decreasing calcitonin gene related peptide (CGRP)

Cited by 37 publications

References 42 publications

Antiinflammatory, Antioxidant, and Immunomodulatory Effects ofCrocus sativusL. and its Main Constituents

Antiinflammatory, Antioxidant, and Immunomodulatory Effects ofCrocus sativusL. and its Main Constituents

Anticancer Effect and Molecular Targets of Saffron Carotenoids

<p>Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats</p>

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