Crocin improves the proliferation and cytotoxic function of T cells in children with acute lymphoblastic leukemia

Zhang, Xiaoying; Wang, Lingzhen; Si, Shaoyong; Sun, Yan; Pei, Wenting; Yan, Ming; Sun, Lirong

doi:10.1016/j.biopha.2018.01.042

Cited by 14 publications

(11 citation statements)

References 9 publications

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“…Also, result showed an increase in CD8 + cells without any significant difference when compared to infected control mice. This result comes in agreement with Zhang et al (2018) who reported that crocin as a one constituent of saffron significantly promoted T cell proliferation and increase CD4/CD8 ratio of T subset of children with acute lymphoblastic leukemia. Also, PZQ exerted significant stimulatory effects on cell immune responses which increase the percentage of CD8 + and reduced the percentage of CD4 + T-cells without any significant difference compared to infected control mice.…”

Section: Discussionsupporting

confidence: 92%

Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice

Shaaban¹,

Ibrahim²,

Mohamed³

2019

Egypt. J. of Aquatic Biolo. and Fish.

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Saffron Granuloma Antioxidants Worm SEMThe present study is designed to evaluate the therapeutic effect of Crocus sativus(saffron) aqueous extract (CSE) alone or in combination with praziquantel on Schistosoma mansoni infected mice. Parasitological, immunological, pathological and immunohistochemical parameters and surface topography of worms were determined. Treatment of S. mansoni infected mice with saffron or PZQ revealed a significant reduction in worm burden, hepatic and intestinal ova count with a decline in granuloma diameter. There was an increase in total IgG and IL-10 blood levels after treatment with PZQ and/or CSE. Superoxide dismutase (SOD) and catalase levels were improved in infected mice treated with CSE in comparison with infected mice. Male worm surface ultrastructure examination showed a swelling, rupture of numerous tubercles with marked decrease in spines and severe peeling of tegumental dorsal surfaces after treatment with saffron. In conclusion, administration of aqueous extract of Crocus sativus is effective treatment for S. mansoni infection.

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Section: Discussionsupporting

confidence: 92%

Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice

Shaaban¹,

Ibrahim²,

Mohamed³

2019

Egypt. J. of Aquatic Biolo. and Fish.

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“…Saffron tea has been reputed to be a potential complementary treatment for psoriasis in medical nutrition therapy [13]. Many pharmacological studies have shown that this plant and its phytochemicals have emerged as nutraceutical elements, endowed with beneficial effects on health showing antibacterial [14], antioxidant, cytotoxic [15,16], antifungal [17], immunomodulatory [18,19], anti-mutagenic [20], aphrodisiac [21], antitussives [22,23], and antiplatelet effects [24]. Traditional and modern biomedical reports have also proved saffron to cure coronary artery diseases [25], respiratory diseases [26], menstrual disorders [27,28], and neurodegenerative disorders [29].…”

Section: Introductionmentioning

confidence: 99%

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan

Muhamad

Ismail

et al. 2020

Plants

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Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate, carrageenan-induced paw edema, capillary tube and forced swim test, respectively in mice. The results indicated that among all the extracts, stigma ethanolic extract (SEE) represented maximum latency activity (72.85%) and edema inhibition (77.33%) followed by petal ethanolic extract (PEE) with latency activity and edema inhibition of 64.06 and 70.50%, respectively. Corm ethanolic extract (CEE) and leaf ethanolic extract (LEE) displayed mild analgesic activity of 22.40% and 29.07%, respectively. Additionally, LEE (53.29%) and CEE (47.47%) exhibited mild to moderate response against inflammation. The coagulation time of SEE (101.66 s) was almost equivalent to the standard drug, aspirin (101.66 s), suggesting a strong anticoagulant effect followed by PEE (86.5 s). LEE (66.83 s) represented moderate inhibitory effect on coagulation activity while CEE (42.83 s) showed neutral effect. Additionally, PEE and SEE also expressed itself as potential antidepressants with immobility time ≤76.66 s, while CEE (96.50 s) and LEE (106.83 s) indicated moderate to mild antidepressant efficacy. Based on the in vivo activities, saffron extract, particularly SEE and PEE, can be used as a potential nutraceutical and therapeutic agent due to its significant pharmacological activities.

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“…In this study, the neutral single-cell gel electrophoresis method was used for detection, which mainly detected the breaking of DNA double strands, with high specificity. Compared with other parameters, and TM and TDNA had a higher correlation with the degree of DNA damage and were more sensitive and accurate [17,18]. According to the research of Chen et al [19], although many mosaic algorithms are implemented based on SIFT algorithm, radiation damage suffered by cardiovascular intervention patients is generally acute radiation damage.…”

Section: Discussionmentioning

confidence: 99%

Image Mosaic Algorithm-Based Analysis of Effects of Low-Dose X-Rays on Blood Immune Cells

Miao

Guo

et al. 2021

Scientific Programming

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This work aimed to explore the effects of image mosaic algorithm- (IMA-) based low-dose X-rays on deoxyribonucleic acid (DNA) damage of peripheral blood lymphocytes in cardiovascular patients. 84 patients with interventional cardiovascular surgeries were selected as the research objects and divided into coronary intervention surgery (A) group, coronary angiography (B) group, radiofrequency ablation (C) group, and permanent cardiac pacemaker implantation (D) group. They were treated with IMA-based low-dose X-rays, DNA damage indicators of lymphocytes were detected, and the relationship was analyzed between those indicators and radiation dose. Results showed that the cumulative dose (CD) and dose area product (DAP) of group A were the lowest, and those of group D were obviously higher than those of the other three groups ( P < 0.01 ). Besides, the results also showed that the values of CD and DAP of patients from group A and group D were 0.38 ± 0.08 (Gy) and 0.38 ± 0.08 (Gy/cm2) and 1.37 ± 0.21 (Gy) and 1.37 ± 0.21(Gy/cm2), respectively. The comet tail DNA content (TDNA) and tail moment (TM) of each group after surgery increased dramatically compared with before surgery ( P < 0.01 ), and the TDNA and TM of group D were greatly higher than those of the other three groups ( P < 0.01 ). Therefore, TDNA and TM were markedly positively correlated with DAP and CD ( P < 0.01 ). IMA-based X-ray radiotherapy caused reliable DNA damage to peripheral blood lymphocytes of cardiovascular patients, and the greater the radiation dose, the more serious the DNA damage.

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Crocin improves the proliferation and cytotoxic function of T cells in children with acute lymphoblastic leukemia

Cited by 14 publications

References 9 publications

Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice

Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Image Mosaic Algorithm-Based Analysis of Effects of Low-Dose X-Rays on Blood Immune Cells

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