Crocin-loaded nanoliposomes: Preparation, characterization, and evaluation of anti-inflammatory effects in an experimental model of adjuvant-induced arthritis

Mohammadi, Ghobad; Korani, Mohsen; Nemati, Houshang; Nikpoor, Amin Reza; Rashidi, Khodabakhsh; Varmira, Kambiz; Abbasifard, Mitra; Kesharwani, Prashant; Korani, Shahla; Sahebkar, Amirhossein

doi:10.1016/j.jddst.2022.103618

Cited by 5 publications

(2 citation statements)

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“…Therefore, there is a need to develop an effective delivery system to enhance crocin's physicochemical properties and overall efficacy. Previous research has explored various strategies, such as polymeric particles ( 6 ), nanoemulsions ( 7 ), liposomes ( 8 ), and niosomes ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Crocin-Phospholipid Complex: Molecular Docking, Molecular Dynamics Simulation, Preparation, Characterization, and Antioxidant Activity

Rezaee,

Karami

et al. 2024

Iran J Pharm Res

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Background: Crocin is a water-soluble carotenoid compound present in saffron (Crocus sativus L.), known for its wide range of pharmacological activities, including cardioprotective, hepatoprotective, anti-tumorigenic, anti-atherosclerosis, and anti-inflammatory effects. Objectives: The instability of crocin, its low miscibility with oils, and poor bioavailability pose challenges for its pharmaceutical applications. This study aimed to design and prepare a crocin-phospholipid complex (CPC) and assess its physicochemical properties. Methods: The study investigated the formation of the complex and its binding affinity through molecular docking. Molecular dynamics (MD) simulations were conducted to find the optimal molar ratio of crocin to phospholipid for the complex's preparation. The CPC was produced using the solvent evaporation method. Techniques such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), field-emission scanning electron microscopy (FE-SEM), nuclear magnetic resonance (NMR), and solubility studies were utilized to characterize and confirm the formation of CPC. Additionally, the in vitro antioxidant activity of crocin and CPC was evaluated. Results: Molecular dynamic simulations explored molar ratios of 1: 1, 1: 1.5, and 1: 2 for crocin to phospholipid. The ratio of 1: 2 was found to be the most stable, exhibiting the highest probability of hydrogen bond formation. Molecular docking, FTIR, and NMR studies indicated hydrogen bond interactions between crocin and phospholipid, confirming CPC's formation. XRD and FE-SEM analyses showed a decrease in crocin's crystallinity within the phospholipid complex. Furthermore, the solubility of crocin in n-octanol was enhanced post-complexation, indicating an increase in crocin's lipophilic nature. Conclusions: Phospholipid complexation emerges as a promising technique for enhancing the physicochemical characteristics of crocin.

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Section: Introductionmentioning

confidence: 99%

“…Previous research has explored various strategies, such as polymeric particles (6), nanoemulsions (7), liposomes (8), and niosomes (9).…”

mentioning

confidence: 99%

Crocin-Phospholipid Complex: Molecular Docking, Molecular Dynamics Simulation, Preparation, Characterization, and Antioxidant Activity

Rezaee,

Karami

et al. 2024

Iran J Pharm Res

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Effect of saffron, black seed, and their main constituents on inflammatory cytokine response (mainly TNF-α) and oxidative stress status: an aspect on pharmacological insights

Vafaeipour

Rahbardar

Hosseinzadeh

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Future prospect of nano-based drug delivery approaches against pancreatic cancer and expected pitfalls of the technology

Manu,

Kaur,

Kar

et al. 2024

Recent Advances in Nanocarriers for Pancreatic Cancer Therapy

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Crocin-loaded nanoliposomes: Preparation, characterization, and evaluation of anti-inflammatory effects in an experimental model of adjuvant-induced arthritis

Cited by 5 publications

References 50 publications

Crocin-Phospholipid Complex: Molecular Docking, Molecular Dynamics Simulation, Preparation, Characterization, and Antioxidant Activity

Crocin-Phospholipid Complex: Molecular Docking, Molecular Dynamics Simulation, Preparation, Characterization, and Antioxidant Activity

Effect of saffron, black seed, and their main constituents on inflammatory cytokine response (mainly TNF-α) and oxidative stress status: an aspect on pharmacological insights

Future prospect of nano-based drug delivery approaches against pancreatic cancer and expected pitfalls of the technology

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