2021
DOI: 10.4084/mjhid.2021.049
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Crocin Promotes Apoptosis in Human Ebv-Transformed B-Lymphocyte via Intrinsic Pathway

Abstract: Background: As a major carotenoid in saffron, crocin demonstrates potent anti-cancer impacts. However, its anti-lymphoma effects remain vague, especially in the human EBV-associated B-cell lymphoproliferative disorders. This study examined crocin's apoptogenic potential and its underlying mechanism in CO 88BV59-1 cell line vs. normal human peripheral blood B cells. Methods: CO 88BV59-1 cells were treated with crocin alone or in combination with vincristine for up to 72 h. The cell viability was examined using … Show more

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Cited by 5 publications
(2 citation statements)
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“…The main biological function of p53 is to maintain the stability of cell genome, negatively regulate cell growth, and induce apoptosis. As revealed in a previous study ( Jahromi et al, 2021 ), the growth of CO 88BV59-1 cells treated with crocin is significantly inhibited, and the expression of p53 is up-regulated. These findings indicate that crocin can promote apoptosis of CO 88BV59-1 cells in lymphoma in a time- and concentration-dependent manner by inducing the P53-dependent intrinsic pathway.…”
Section: Induction Of Apoptosis In Tumor Cellssupporting
confidence: 68%
“…The main biological function of p53 is to maintain the stability of cell genome, negatively regulate cell growth, and induce apoptosis. As revealed in a previous study ( Jahromi et al, 2021 ), the growth of CO 88BV59-1 cells treated with crocin is significantly inhibited, and the expression of p53 is up-regulated. These findings indicate that crocin can promote apoptosis of CO 88BV59-1 cells in lymphoma in a time- and concentration-dependent manner by inducing the P53-dependent intrinsic pathway.…”
Section: Induction Of Apoptosis In Tumor Cellssupporting
confidence: 68%
“…Although there are advances in the use of herbal medicine in cancer treatment (Shakeri et al, 2020;Jahromi et al, 2021;Muhammad et al, 2022), pharmaceutical treatments and their side effects are still a major challenge in cancer therapy (Khamisipour et al, 2016;Kokhaei et al, 2016). The use of immunological biomarkers can therefore be useful in the differential diagnosis or targeted treatment of different types of cancer (Berraondo et al, 2019).…”
Section: Discussionmentioning
confidence: 99%