Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH

Guha, Samit; Shaw, Gillian Karen; Mitcham, Trevor; Bouchard, Richard R.; Smith, Bradley D.

doi:10.1039/c5cc08317f

Cited by 76 publications

(73 citation statements)

References 46 publications

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“…We altered the composition of liposomes containing a lipophilic near-infrared pH-sensitive dye and maximized the change in ratiometric photoacoustic signal produced when the liposomes were in the acidic peritoneal cavity of a living mouse. 34 While the two liposome sensors in this present study use anionic membrane additives to raise the probe p K a values, there is no doubt that cationic additives would produce the reverse trend. But in the case of membrane-anchored probes 2 and 4 this would lower the p K a values to < 5, which does not have much biological relevance.…”

Section: Resultsmentioning

confidence: 75%

Using membrane composition to fine-tune the pK_a of an optical liposome pH sensor

et al. 2016

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Liposomes containing membrane-anchored pH-sensitive optical probes are valuable sensors for monitoring pH in various biomedical samples. The dynamic range of the sensor is maximized when the probe pKa is close to the expected sample pH. While some biomedical samples are close to neutral pH there are several circumstances where the pH is 1 or 2 units lower. Thus, there is a need to fine-tune the probe pKa in a predictable way. This investigation examined two lipid-conjugated optical probes, each with appended deep-red cyanine dyes containing indoline nitrogen atoms that are protonated in acid. The presence of anionic phospholipids in the liposomes stabilized the protonated probes and increased the probe pKa values by < 1 unit. The results show that rational modification of the membrane composition is a general non-covalent way to fine-tune the pKa of an optical liposome sensor for optimal pH sensing performance.

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Section: Resultsmentioning

confidence: 75%

Using membrane composition to fine-tune the pK_a of an optical liposome pH sensor

et al. 2016

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“…Recently, other optoacoustic pH sensors e.g. based on micelles [249], liposomes [250], self-assembled nanoprobes [251], semiconducting oligomer nanoparticles [252], dextran-based nanoprobes [253] or gold nanoparticles [254] have been developed.…”

Section: Dynamic Contrast Enhancement Approachesmentioning

confidence: 99%

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

et al. 2017

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Visualization of dynamic functional and molecular events in an unperturbed in vivo environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive capacity to maintain excellent optical contrast and high resolution in deep-tissue observations, far beyond the penetration limits of modern microscopy. Yet, the time domain is paramount for the observation and study of complex biological interactions that may be invisible in single snapshots of living systems. This review focuses on the recent advances in optoacoustic imaging assisted by smart molecular labeling and dynamic contrast enhancement approaches that enable new types of multiscale dynamic observations not attainable with other bio-imaging modalities. A wealth of investigated new research topics and clinical applications is further discussed, including imaging of large-scale brain activity patterns, volumetric visualization of moving organs and contrast agent kinetics, molecular imaging using targeted and genetically expressed labels, as well as three-dimensional handheld diagnostics of human subjects.

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“…In order to detect pH in vivo , recently, some organic dyes with pH-responsive NIR absorption shift have been exploited as PA contrast agents for PA pH detection 119-121. For example, Liu et al developed a pH-responsive nanoprobe based on albumin-benzo[ a ]phenoxazine (BPOx)-IR825 complexes (HSA-BPOx-IR825) for in vivo ratiometric PA pH imaging (Figure 5A) 119.…”

Section: Biomedical Applications Of Paimentioning

confidence: 99%

Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications

et al. 2016

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Photoacoustic imaging (PAI), a novel imaging modality based on photoacoustic effect, shows great promise in biomedical applications. By converting pulsed laser excitation into ultrasonic emission, PAI combines the advantages of optical imaging and ultrasound imaging, which benefits rich contrast, high resolution and deep tissue penetration. In this paper, we introduced recent advances of contrast agents, applications, and signal enhancement strategies for PAI. The PA contrast agents were categorized by their components, mainly including inorganic and organic PA contrast agents. The applications of PAI were summarized as follows: deep tumor imaging, therapeutic responses monitoring, metabolic imaging, pH detection, enzyme detection, reactive oxygen species (ROS) detection, metal ions detection, and so on. The enhancement strategies of PA signals were highlighted. In the end, we elaborated on the challenges and provided perspectives of PAI for deep-tissue biomedical applications.

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Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH

Cited by 76 publications

References 46 publications

Using membrane composition to fine-tune the pK_a of an optical liposome pH sensor

Using membrane composition to fine-tune the pK_a of an optical liposome pH sensor

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications

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Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH

Cited by 76 publications

References 46 publications

Using membrane composition to fine-tune the pKa of an optical liposome pH sensor

Using membrane composition to fine-tune the pKa of an optical liposome pH sensor

Advanced optoacoustic methods for multiscale imaging of in vivo dynamics

Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications

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Using membrane composition to fine-tune the pK_a of an optical liposome pH sensor

Using membrane composition to fine-tune the pK_a of an optical liposome pH sensor