Crocus sativus L.: A comprehensive review

Srivastava, Rajani; Ahmed, Hiwa M.; Dixit, RK; Dharamveer,; Saraf, Shubhini A.

doi:10.4103/0973-7847.70919

Cited by 257 publications

(177 citation statements)

References 35 publications

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“…Saffron (Crocus sativus L.) is a plant from Iridaceae family, commonly cultivated in Iran and some other countries (6,7). Bitter substances derived from safranal and crocin carotenoid pigment (an important component of saffron stigma) are said to have pharmacological effects (7,8).…”

Section: Introductionmentioning

confidence: 99%

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Mohammadierad¹,

Mohammad‐Alizadeh‐Charandabi²,

Mirghafourvand³

et al. 2018

Iran Red Crescent Med J

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Background: Reduction of pain and anxiety during labor is necessary to prevent some of the maternal and fetal complications, as well as request for cesarean section. There is limited evidence assessing the effects of saffron and dates on intensity of pain and anxiety. Objectives: The current study aimed at examining the effect of saffron with or without dates on the intensity of pain and anxiety during transitional and active phases of labor in primiparous females. Methods: In the current superiority trial, 96 primiparous females admitted to a hospital covered by the iranian social security organization in Tabriz, Iran, at the onset of active phase of labor were recruited using convenience sampling method from 10 January to 21 October 2016. They were randomly divided into three equal groups using block randomization; receiving 80 mL oral syrup of saffron (250 mg) plus date juice (65 g), saffron (250 mg) plus white sugar (165 mg sodium saccharin and 420 mg sodium carboxymethyl cellulose), or placebo every two hours for maximum three doses (240 mL). Intensity of pain and anxiety were assessed using 0-10 visual analogue scale every one hour. Results: Compared with the placebo, mean scores of both pain and anxiety were lower in the intervention groups. The differences were statistically significant at the saffron plus date juice group (adjusted mean difference: -0.8 (95% confidence interval (CI): -1.5 -0.0), P = 0.022 and -1.3 (95% CI: -2.4 to -0.2), P = 0.012, respectively), but were not significant at the saffron plus white sugar group (-0.5 (95% CI: -1.2 -0.2), P = 0.322 and -1.1 (95% CI: -2.2 -0.0), P = 0.058, respectively). The differences between the two intervention groups were not statistically significant (-0.3 (95% CI: -1.0 -0.4), P = 0.557 and -0.2 (95% CI: -1.3 -0.8), P = 0.927, respectively). One subject from saffron plus date juice, three from saffron plus white sugar, and four from the placebo groups had emergency cesarean section. Conclusions: The current study results showed that the oral syrup of saffron plus date juice could be used to reduce the intensity of pain and anxiety during labor in primiparous females. However, the results were inconclusive for the effects of saffron plus white sugar.

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Section: Introductionmentioning

confidence: 99%

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Mohammadierad¹,

Mohammad‐Alizadeh‐Charandabi²,

Mirghafourvand³

et al. 2018

Iran Red Crescent Med J

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“…Saffron increases blood flow in certain tissues 47 affected by aging or chronic oxidative stress. Saffron consumption before tissue exposure to damaging light results in neuro-protective effects through the regulation of various known genes, including the genes encoding the antioxidative GPx3 and ncRNAs.…”

Section: Trigonella Foenum-graecum Seeds (Fenugreek) Chili and Pennymentioning

confidence: 99%

Herbs and Spices in Aging

Mohamed

2014

Aging

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“…Traditionally Saffron has been considered as antispasmodic, aphrodisiac, galactogogue, expectorant and sedative. It has also been used in folk remedy against small pox, scarlet fever, colds, Insomnia, asthma, tumor and other diseases of kidney, liver, spleen and the brain [22]. Saffron extract is also useful for neuro disorders accompanying memory impairment, treatment of mild to moderate depression, reduces stress induced anorexia [23].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2018

RJLBPCS

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ABSTRACT:Cancer is considered as one of the most dreadful diseases of the 20th century and is a major concern. Chemotherapy is the most common modality used for cancer treatment, but is unable to achieve satisfactory effects because of its severe side effects and dose-limiting toxicity. Ample evidence shows that herbal medicine has evolved as a solution for cancer chemoprevention and new drug development. Crocus sativus is reported to be useful in treating various human disorders. It's main constituents have memory improving, anti-oxidant, anti-depressant and anti-tumor properties. The present study was therefore, carried out to unveil the protective potential of saffron in terms of the chromosome damage in tumor bearing mice and cytotoxicity using mice skin cells and human peripheral blood lymphocytes. Chromosomal aberration assay was carried out to unveil the genotoxicity of various saffron extracts. MTT-cytotoxicity assay was carried out to explore the cytotoxicity of the saffron extracts using human peripheral blood lymphocytes and mice skin cells. As compared to standard drug 35mg/kg, 65mg/kg, 165mg/kg and 200mg/kg dosage of saffron stigma were found to produce statistically lower mean aberrant metaphases (p<0.05). Besides, 65mg/kg, 165mg/kg and 200mg/kg dosage of saffron bulb were found to produce statistically lower mean aberrant metaphases (p<0.05). MTT cytotoxicity assay of mice skin cells revealed maximum cytoprotection by 20% methanol stigma and minimum cytotoprotection by 100% saffron bulb extract. MTT cytotoxicity assay of lymphocytes revealed minimum cytoprotection by 100% saffron bulb and maximum cytoprotection by 100% methanol stigma.

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Crocus sativus L.: A comprehensive review

Cited by 257 publications

References 35 publications

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Herbs and Spices in Aging

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