Cronkhite-Canada Syndrome: A Case Report and Literature Review of Gastrointestinal Polyposis Syndrome

Shen, Xiu‐Yu; Husson, Michael A.; Lipshutz, William

doi:10.4236/crcm.2014.312138

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Some studies support treatment with azathioprine, cyclosporine, cromolyn sodium, antibiotics and, rarely, colectomy. 9 Due to the rarity of the disease, appropriate treatment protocols and screening guidelines for malignancy have not established.…”

Section: Discussionmentioning

confidence: 99%

Case of Cronkhite-Canada Syndrome

Raj

Kumar

Agarwal

2020

Journal of Digestive Endoscopy

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Cronkhite–Canada syndrome is a nonhereditary syndrome. It is characterized by cutaneous manifestations and gastrointestinal (GI) polyps. Patients may also present with diarrhea and weight loss. Early diagnosis of disease is important to avoid morbidity and mortality. Definitive treatment is not available for Cronkhite–Canada syndrome but supportive care and symptomatic treatment will improve the symptoms and increase the quality of life.

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Section: Discussionmentioning

confidence: 99%

Case of Cronkhite-Canada Syndrome

Raj

Kumar

Agarwal

2020

Journal of Digestive Endoscopy

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“…The disease is characterized by gastrointestinal symptoms including diarrhoea, abdominal pain, dysgeusia, and weight loss. Later, the dermatologic triad of hyperpigmentation, alopecia, and dystrophic nails often occurs 4 . Endoscopy examination often found multiple diffuse gastrointestinal sessile polyposes except in the oesophagus.…”

Section: Introductionmentioning

confidence: 99%

A case report of Cronkhite–Canada syndrome first encounterd at a hospital in northern Vietnam

Nguyen,

Thi Pham,

Nguyen

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and importance: Cronkhite–Canada syndrome (CCS) is an extremely rare non-inherited syndrome first described in 1955 with only about 500 more cases reported so far. Since the aetiology of the disease remains unknown, there were no specific treatments in consensus. In many countries, CCS is a completely new condition that may confuse physicians at first encounter. Lessons should be learned from these cases by gastrointestinal specialists to be aware of this condition in any circumstances. Case presentation: The authors reported a case study of a 45-year-old Vietnamese male with CCS diagnosis, which encountered at our centre for the first time. Clinical discussion: The definitive diagnosis was provided by combining clinical characteristics, and endoscopic and histopathologic features, after excluding other causes of gastrointestinal polyposis. The patient responds to corticosteroids, proton pump inhibitors, and nutritional support right after treatment. After 1 year of treatment, his symptoms ameliorated completely although colon polyps insignificantly reduced. Conclusion: Gastroenterologists should always be aware of patients with CCS with the following symptoms: gastrointestinal hamartomatous polyps, diarrhoea, and the dermatologic triad of alopecia, hyperpigmentation, and onychodystrophy.

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Cronkhite-Canada syndrome polyps infiltrated with IgG4-positive plasma cells

Fan¹,

Wang²,

Lü³

et al. 2016

WJCC

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Cronkhite-Canada syndrome (CCS) is a rare but serious protein-losing enteropathy, but little is known about the mechanism. Further more, misdiagnosis is common due to non-familiarity of its clinical manifestation. A 40-year-old male patient was admitted to our hospital because of diarrhea and hypogeusia associated with weight loss for 4 mo. On physical examination, skin pigmentation, dystrophic nail changes and alopecia were noted. He had no alike family history. Laboratory results revealed low levels of serum albumin (30.1 g/L, range: 35.0-55.0 g/L), serum potassium (2.61 mmol/L, range: 3.5-5.5 mmol/L) and blood glucose (2.6 mmol/L, range: 3.9-6.1 mmol/L). The erythrocyte sedimentation rate was elevated to 17 mm/h (range: 0-15 mm/h). X-ray of chest and mandible was normal. The endoscopic examination showed multiple sessile polyps in the stomach, small bowel and colorectum. Histopathologic examination of biopsies obtained from those polyps showed hyperplastic change, cystic dilatation and distortion of glands with inflammatory infiltration, eosinophilic predominance and stromal edema. Immune staining for IgG4 plasma cells was positive in polyps of stomach and colon. The patient was diagnosed of CCS and treated with steroid, he had a good response to steroid. Both histologic findings and treatment response to steroid suggested an autoimmune mechanism underling CCS.

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Cronkhite-Canada Syndrome: A Case Report and Literature Review of Gastrointestinal Polyposis Syndrome

Cited by 3 publications

References 30 publications

Case of Cronkhite-Canada Syndrome

Case of Cronkhite-Canada Syndrome

A case report of Cronkhite–Canada syndrome first encounterd at a hospital in northern Vietnam

Cronkhite-Canada syndrome polyps infiltrated with IgG4-positive plasma cells

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