Pavlodar region is the largest industrial center of Kazakhstan. There are three cities with developed industries in the region: Pavlodar, Ekibastuz, and Aksu. A diversified industrial complex has developed in the region, which is focused on the production of electricity, alumina, oil products, mechanical engineering, the food industry, and building materials. The consequences of the rapid development of industry in the Pavlodar region were the highest rate of emissions of pollutants into the atmosphere in the Republic of Kazakhstan. According to the observations of environmentalists, the state of the atmospheric air in the region has deteriorated since the 1990s. Air pollution in industrial cities has a detrimental effect not only on human life, but also on animals, plants, and microorganisms, and also damages the economy of the region. Enormous damage to the waters of the Irtysh is caused by the enterprises of Pavlodar, as well as many enterprises of the East Kazakhstan region, the territory of which flows through most of the Irtysh River. Another no less significant environmental problem is the chemical pollution of the city of Pavlodar with mercury, associated with the Pavlodar chemical plant. Thus, one of the main tasks of the region is to improve the environmental situation.