Cross Brain–Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors

Taghian, Farzaneh; Taghian, Farzaneh; Hajibabaie, Fatemeh

doi:10.1007/s12035-022-02835-1

Cited by 35 publications

(21 citation statements)

References 65 publications

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“…84,91 Besides, endurance exercise and leucine consumption modified the hub genes and lncRNAs involved in the brain-gut axis in mice with depression-like behaviors. 76 In the current study, the authors found common genes, including Kdr/Vegfα/Pten/Bdnf, between the hippocampus region and ileum tissue. Moreover, some mediators such as lncRNAs such as MEG3 (maternally expressed 3), GAS5 (growth arrest-specific 5), TUG1 (taurine up-regulated 1), and HOTAIR (HOX transcript antisense RNA) could target the Kdr/Vegfα/Pten/Bdnf hub genes and modified by endurance exercise and leucine consumption.…”

Section: Non-coding Rnas and Oxidative Stress In The Management Of Ty...supporting

confidence: 48%

“…8,75 Typically a nucleotide sequence of over 200 bp displaying as long noncoding RNAs (lncRNAs) influences gene expression by many mechanisms. 76 Both the linear and the circular forms of lncRNAs are found in cells and the extracellular space. 77 The RNAs that exist in a circular structure are referred to as circular RNAs (circRNAs).…”

Section: Non-coding Rnas and Oxidative Stress In The Management Of Ty...mentioning

confidence: 99%

“…Moreover, some mediators such as lncRNAs such as MEG3 (maternally expressed 3), GAS5 (growth arrest-specific 5), TUG1 (taurine up-regulated 1), and HOTAIR (HOX transcript antisense RNA) could target the Kdr/Vegfα/Pten/Bdnf hub genes and modified by endurance exercise and leucine consumption. 76 In addition, several evidence indicated that lifestyles such as physical activity and unhealthy diets could impact fertility and sperm function. 92,93 High-fat diet and diet enriched advanced glycation end products dysregulated the function, parameters, and intracellular reactive oxygen species of sperm.…”

Section: Non-coding Rnas and Oxidative Stress In The Management Of Ty...mentioning

confidence: 99%

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Pathomechanisms of non-coding RNAs and hub genes related to the oxidative stress in diabetic complications

Hajibabaie

Aali²,

Taghian³

2022

F1000Res

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Cytokine storms, oxidative stress, and hyperglycemia can enhance the risk of type 2 diabetes (T2D). Moreover, T2D may change the functional and structural heart. However, some signaling pathways, such as insulin resistance, dyslipidemia, and hyperglycemia, can play in T2D, and various pathomechanics and pathophysiology involved in T2D are not understood. Moreover, it is well documented that the non-coding RNAs are potentially pivotal molecules in oxidative stress, inflammation, and cell death signaling pathways. Hence, long non-coding RNAs (lncRNAs) and microRNAs may have vital roles in oxidative stress, inflammation, metabolism, T2D, and cardiovascular systems. Non-coding RNAs can target hub gene networks and suppress or trigger various cascades. Furthermore, lifestyle is the other factor that may affect the prevalence of T2D. A sedentary lifestyle and excessive sitting can enhance inflammation, oxidative stress, and hyperglycemia. Here, we attempt to comprehend the role of hub genes, non-coding RNAs, and unhealthy lifestyles on the pathomechanics and pathophysiology of diabetic vascular complications.

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Section: Non-coding Rnas and Oxidative Stress In The Management Of Ty...supporting

confidence: 48%

Section: Non-coding Rnas and Oxidative Stress In The Management Of Ty...mentioning

confidence: 99%

Section: Non-coding Rnas and Oxidative Stress In The Management Of Ty...mentioning

confidence: 99%

See 1 more Smart Citation

Pathomechanisms of non-coding RNAs and hub genes related to the oxidative stress in diabetic complications

Hajibabaie

Aali²,

Taghian³

2022

F1000Res

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“…Recently, the roles of lncRNA in the pathogenesis of depression have been shown to regulate synaptic plasticity, Bdnf expression, inflammation and so on [ 60 ]. LncRNA networks are differentially modified during endurance exercise in mice with depression-like behaviors [ 61 ]. Further, it was confirmed that Baduanjin can effectively ameliorate the symptoms of depression in patients with depression by regulating the dysregulated expression of lncRNA, mRNA, and circRNA [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Gene expression profile associated with Asmt knockout-induced depression-like behaviors and exercise effects in mouse hypothalamus

et al. 2022

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Sleep disorder caused by abnormal circadian rhythm is one of the main symptoms and risk factors of depression. As a known hormone regulating circadian rhythms, melatonin (MT) is also namely N-acetyl-5-methoxytryptamine. N-acetylserotonin methyltransferase (Asmt) is the key rate-limiting enzyme of MT synthesis, and has been reportedly associated with depression. Although 50% to 90% of patients with depression have sleep disorders, there are no effective treatment ways in the clinic. Exercise can regulate circadian rhythm and play an important role in depression treatment. In the present study, we showed that Asmt knockout induced depression-like behaviors, which were ameliorated by swimming exercise. Moreover, swimming exercise increased serum levels of MT and 5-hydroxytryptamine (5-HT) in Asmt knockout mice. In addition, the microarray data identified 10 differentially expressed genes (DEGs) in KO mice compared with WT mice, and 29 DEGs in KO mice after swimming exercise. Among the DEGs, the direction and magnitude of change in epidermal growth factor receptor pathway substrate 8-like 1 (Eps8l1) and phospholipase C-β 2 (Plcb2) were confirmed by qRT-PCR partly. Subsequent bioinformatic analysis showed that these DEGs were enriched significantly in the p53 signaling pathway, long-term depression and estrogen signalling pathway. In the protein-protein interaction (PPI) networks, membrane palmitoylated protein 1 (Mpp1) and p53 induced death domain protein 1 (Pidd1) were hub genes to participate in the pathological mechanisms of depression and exercise intervention. These findings may provide new targets for the treatment of depression.

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“…Evidence has indicated that oxidative stress might have an indispensable role in the pathogenesis of diabetes and its vascular complications; Therefore, antioxidant therapy and physical activity (PA) are suggested as effective approaches for diabetes treatment (Abedpoor et al, 2022a; Davargaon et al, 2019). To ensure optimal heart physiology, maintaining a balanced redox state is required.…”

Section: Introductionmentioning

confidence: 99%

Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti‐apoptotic process

Heydarnia

Taghian

Dehkordi

et al. 2022

Journal of Food Biochemistry

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The apoptosis process could impose significantly by hyperglycemia. According to in silico language processing and high throughput raw data analysis, we recognized hub molecular mechanisms involved in the pathogenesis of diabetic hearts and suggested a new pharmaceutical approach for declining myocardial programed cell death. Fifty male Sprague-Dawley rats were classified into five groups: healthy rats as control, diabetic rats, diabetic combined resistance/endurance training, diabetic rats which How to cite this article: Heydarnia, E., Taghian, F., Jalali Dehkordi, K., & Moghadasi, M. (2022). Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti-apoptotic process.

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Cross Brain–Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors

Cited by 35 publications

References 65 publications

Pathomechanisms of non-coding RNAs and hub genes related to the oxidative stress in diabetic complications

Pathomechanisms of non-coding RNAs and hub genes related to the oxidative stress in diabetic complications

Gene expression profile associated with Asmt knockout-induced depression-like behaviors and exercise effects in mouse hypothalamus

Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti‐apoptotic process

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