2011
DOI: 10.1038/npp.2011.98
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Cross-Disorder Analysis of Bipolar Risk Genes: Further Evidence of DGKH as a Risk Gene for Bipolar Disorder, but also Unipolar Depression and Adult ADHD

Abstract: Recently, several genome-wide association studies (GWAS) on bipolar disorder (BPD) suggested novel risk genes. However, only few of them were followed up and further, the specificity of these genes is even more elusive. To address these issues, we genotyped SNPs in ANK3, CACNA1C, CMTM8, DGKH, EGFR, and NPAS3, which were significantly associated with BPD in previous GWAS, in a sample of 380 BPD patients. Replicated SNPs were then followed up in patients suffering from unipolar depression (UPD; n=387) or adult a… Show more

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Cited by 95 publications
(77 citation statements)
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“…Therefore, our current results encourage us to identify and develop specifi c inhibitors/activators against every DGK isozyme that can be effective regulators and drugs against a wide variety of physiological events and diseases ( 4 ). For example, DGK ␣ : cancer cell growth ( 9,10,37,40 ), angiogenesis ( 41 ), T-cell proliferation ( 45 ), and T-cell anergy ( 12, 13 ); DGK ␤ : bipolar disorder ( 46, 47 ); DGK ␥ : actin reorganization ( 19 ), allergy ( 48 ), and insulin secretion ( 49 ); DGK ␦ : epidermal growth factor receptor signaling ( 50 ) and type 2 diabetes ( 51, 52 ); DGK : epidermal growth factor receptor signaling ( 53 ), lung cancer ( 54 ), bipolar disorder ( 55,56 ), unipolar depression ( 56 ), and attention-defi cit/hyperactivity disorder ( 56 ); DGK : hypospadias ( 57 ); DGK : seizure susceptibility/ long-term potentiation ( 58 ) and Huntington's disease ( 59 ); DGK : cell growth ( 60 ), T-cell receptor response ( 61 ), and brain ischemia ( 62 ); DGK : Ras signaling ( 63 ); and DGK : Parkinson's disease ( 64 ) and bile acid signaling ( 65 ).…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, our current results encourage us to identify and develop specifi c inhibitors/activators against every DGK isozyme that can be effective regulators and drugs against a wide variety of physiological events and diseases ( 4 ). For example, DGK ␣ : cancer cell growth ( 9,10,37,40 ), angiogenesis ( 41 ), T-cell proliferation ( 45 ), and T-cell anergy ( 12, 13 ); DGK ␤ : bipolar disorder ( 46, 47 ); DGK ␥ : actin reorganization ( 19 ), allergy ( 48 ), and insulin secretion ( 49 ); DGK ␦ : epidermal growth factor receptor signaling ( 50 ) and type 2 diabetes ( 51, 52 ); DGK : epidermal growth factor receptor signaling ( 53 ), lung cancer ( 54 ), bipolar disorder ( 55,56 ), unipolar depression ( 56 ), and attention-defi cit/hyperactivity disorder ( 56 ); DGK : hypospadias ( 57 ); DGK : seizure susceptibility/ long-term potentiation ( 58 ) and Huntington's disease ( 59 ); DGK : cell growth ( 60 ), T-cell receptor response ( 61 ), and brain ischemia ( 62 ); DGK : Ras signaling ( 63 ); and DGK : Parkinson's disease ( 64 ) and bile acid signaling ( 65 ).…”
Section: Discussionmentioning
confidence: 99%
“…Further, an association of DGKH with BD has been replicated in a Sardinian as well as a Chinese sample at the haplotype level (Zeng et al, 2011;Squassina et al, 2009). A recent study also reported an association of DGKH with BD, as well as unipolar depression and adult attention deficits/hyperactivity disorder (Weber et al, 2011). In addition, SNP rs9315885 has been associated with BD in a Finnish family cohort (Ollila et al, 2009), and the GWAS carried out by the Wellcome Trust Case Control Consortium (The Wellcome Trust Case Control Consortium, 2007) indicated association for several SNPs near and within DGKH Robbins and Arnsten, 2009).…”
Section: Introductionmentioning
confidence: 78%
“…Seneviratne et al (2013) and Johnson et al (2013) demonstrated that Caucasian or European American subjects carrying one or more specific alleles of the HTR3A and HTR3B genes have significant differences in their responses to ondansetron vs. placebo in terms of drinking (Barker et al, 2013;Tang et al, 2013). Additionally, the interactions of these variants significantly affected alcohol dependency (Weber et al, 2011;Johnson et al, 2013;Seneviratne et al, 2013). However, consistently susceptible gene factors associated with BPD were not found.…”
Section: Introductionmentioning
confidence: 96%