Cross-link between type 2 diabetes mellitus and iron deficiency anemia. A mini-review

Mokgalaboni, Kabelo; Phoswa, Wendy N.

doi:10.1016/j.nutos.2022.08.006

Cited by 4 publications

(5 citation statements)

References 103 publications

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“…76 Saponins enhance the activities of various antioxidant enzymes such as catalases and superoxide dismutase, which is usually lowered in hyperglycemic conditions. 77 The various plant extracts are cost-effective, safe, and environmentally benign for the creation of NPs, 78,79 So in the present project KE-AgNPs were successfully synthesized from KE extract via green processing. Standardizations was done for the biosynthesis of KE-AgNPs in terms of extract concentration, AgNO 3 salt molarity, temperature, time, stability period, and pH value.…”

Section: Discussionmentioning

confidence: 94%

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Bio‐fabrication and characterization of nano‐silver using Kickxia elatine plant and its anti‐diabetic effect on alloxan‐induced Sprague Dawley rats — An in vivo approach

Huda,

Ahmed,

Mushtaq

2023

Applied Organom Chemis

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Diabetes mellitus (DM) is one of the most prevalent, fatal, and non‐contagious diseases. Therefore, researchers are making attempts to develop novel anti‐diabetic drugs using various organic compounds and biomolecules. The idea of using nano‐materials as anti‐diabetic agents seems interesting. The current study aims to develop Kickxia elatine (KE) extract‐based nano‐silver (KE‐AgNPs) and to evaluate their in vivo anti‐diabetic potency in female Sprague Dawley rats. KE‐AgNPs were characterized using UV spectroscopy, X‐ray diffractometer (XRD), scanning electron microscopy (SEM), Electron Diffraction X‐ray Spectroscopy (EDX), and Fourier transforms infrared (FTIR) techniques. The crystalline nature of KE‐AgNPs with a size of 42.47 nm is confirmed by XRD screening. Spherical‐shaped mono‐dispersed KE‐AgNPs with a mean size of 50 nm are validated by SEM examination. The different phyto‐compounds (tannins, alkaloids, flavonoids, proteins, saponins, phenols, carbohydrates, quinones, sterols, fats, and oils) that contribute to the stabilization and reduction of KE‐AgNPs are confirmed by FTIR analysis. EDX showed a strong peak (3.2 keV) that identified Ag as the main component with a 61.67% contribution. The use of Alloxan to induce diabetes resulted in elevated levels of blood sugar, HbA1c, liver, and lipid profile, as well as a drastic reduction in body weight, body organ weight, and Hemoglobin. These modifications were switched following 21 days of treatment of diabetic rats, and a dosage range of 150–450 mg kg−1 BW of KE extract and KE‐AgNPs demonstrated significant inhibition as compared with the diabetic untreated group. The phytochemical analysis of the KE plant was also assessed to examine the phyto‐compounds involved in the anti‐diabetic potential of KE extract and KE‐AgNPs. These findings suggested that, in comparison with the KE extract, KE‐AgNPs have demonstrated promising anti‐diabetic action.

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Section: Discussionmentioning

confidence: 94%

“…It has been demonstrated that tannins minimize the risk of developing diabetes by improving glucose absorption and lowering blood sugar levels 76 . Saponins enhance the activities of various antioxidant enzymes such as catalases and superoxide dismutase, which is usually lowered in hyperglycemic conditions 77 …”

Section: Discussionmentioning

confidence: 99%

Bio‐fabrication and characterization of nano‐silver using Kickxia elatine plant and its anti‐diabetic effect on alloxan‐induced Sprague Dawley rats — An in vivo approach

Huda,

Ahmed,

Mushtaq

2023

Applied Organom Chemis

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“…Research reports has established common causes of microcytic anaemia to include iron deficiency, inflammatory diseases and thalassemia [53], dietary deficiency of vitamin C and gastrointestinal disorders [54]. Research findings has shown that diabetes can contribute to anaemia through reduced absorption of iron, gastrointestinal bleeding and neuropathy [55]. The observed increase in MCV by aspirin, meloxicam and in combination with Terminalia catappa extract indicates correction of the suspected microcytic anaemia.…”

Section: Discussionmentioning

confidence: 99%

Aspirin and meloxicam co-administration with leaf extract of Terminalia catappa; prevention of red blood cell related cardiovascular complications in alloxan induced diabetic rats

Ezekiel E. Ben,

Asuquo E. Asuquo,

Okon, I. Asuquo

et al. 2024

GSC Biol. Pharm. Sci.

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Hyperglycemia induced alterations in red blood cell parameters are associated with cardiovascular complications in diabetes mellitus. This study was designed to investigate abnormalities in red blood cell parameters and changes due to aspirin and meloxicam administrations in diabetic rats. Thirty-six (36) healthy male Wistar rats weighting 150-200g were used for the study. The animals were randomly distributed into six groups of six rats each. Group 1 and 2 respectively served as control and diabetic groups administered with 5 ml/kg body weight of distilled water orally. Groups 3 and 4 were diabetic rats treated with aspirin and meloxicam at 30 mg/kg and 2 mg/kg body weight respectively. A combined administration of aspirin and meloxicam at their respective doses with 130mg/kg body weight of Terminalia catappa extract was in groups 5 and 6. The results showed that RBC count, PCV, HGB and MCV were reduced significantly (p<0.05) in diabetic group but significantly (p<0.05) increased in aspirin, meloxicam and in combined extract treated groups of diabetic rats. Therefore, diabetic induced alterations in red blood cell parameters which maybe attributed to inflammation were reversed by aspirin and meloxicam. Co-administration of these NSAID with T. catappa leaf extract would enhance their safety use in prevention of cardiovascular complications in diabetes mellitus.

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“…The perturbation of insulin signaling exacerbates the distribution of iron in neuronal tissues, resulting in neuronal iron overload and potential complications including neuropathy ( 18 ). Furthermore, T2DM is implicated in the genesis of diverse comorbidities and complications including iron deficiency anemia (IDA) ( 19 ). Iron metabolism parameters undergo modifications due to the influence of T2DM, leading to changes such as elevated ferritin and hepcidin levels ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, T2DM is implicated in the genesis of diverse comorbidities and complications including iron deficiency anemia (IDA) ( 19 ). Iron metabolism parameters undergo modifications due to the influence of T2DM, leading to changes such as elevated ferritin and hepcidin levels ( 19 ). Notably, serum ferritin levels exhibit a discernible association with T2DM ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Quantitative susceptibility mapping for iron monitoring of multiple subcortical nuclei in type 2 diabetes mellitus: a systematic review and meta-analysis

Mohammadi,

Ghaderi,

Sayehmiri

et al. 2024

Front. Endocrinol.

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IntroductionIron accumulation in the brain has been linked to diabetes, but its role in subcortical structures involved in motor and cognitive functions remains unclear. Quantitative susceptibility mapping (QSM) allows the non-invasive quantification of iron deposition in the brain. This systematic review and meta-analysis examined magnetic susceptibility measured by QSM in the subcortical nuclei of patients with type 2 diabetes mellitus (T2DM) compared with controls.MethodsPubMed, Scopus, and Web of Science databases were systematically searched [following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines] for studies reporting QSM values in the deep gray matter (DGM) regions of patients with T2DM and controls. Pooled standardized mean differences (SMDs) for susceptibility were calculated using fixed-effects meta-analysis models, and heterogeneity was assessed using I2. Sensitivity analyses were conducted, and publication bias was evaluated using Begg’s and Egger’s tests.ResultsSix studies including 192 patients with T2DM and 245 controls were included. This study found a significant increase in iron deposition in the subcortical nuclei of patients with T2DM compared to the control group. The study found moderate increases in the putamen (SMD = 0.53, 95% CI 0.33 to 0.72, p = 0.00) and dentate nucleus (SMD = 0.56, 95% CI 0.27 to 0.85, p = 0.00) but weak associations between increased iron levels in the caudate nucleus (SMD = 0.32, 95% CI 0.13 to 0.52, p = 0.00) and red nucleus (SMD = 0.22, 95% CI 0.00 0.44, p = 0.05). No statistical significance was found for iron deposition alterations in the globus pallidus (SMD = 0.19; 95% CI −0.01 to 0.38; p = 0.06) and substantia nigra (SMD = 0.12, 95% CI −0.10, 0.34, p = 0.29). Sensitivity analysis showed that the findings remained unaffected by individual studies, and consistent increases were observed in multiple subcortical areas.DiscussionQSM revealed an increase in iron in the DGM/subcortical nuclei in T2DM patients versus controls, particularly in the motor and cognitive nuclei, including the putamen, dentate nucleus, caudate nucleus, and red nucleus. Thus, QSM may serve as a potential biomarker for iron accumulation in T2DM patients. However, further research is needed to validate these findings.

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Cross-link between type 2 diabetes mellitus and iron deficiency anemia. A mini-review

Cited by 4 publications

References 103 publications

Bio‐fabrication and characterization of nano‐silver using Kickxia elatine plant and its anti‐diabetic effect on alloxan‐induced Sprague Dawley rats — An in vivo approach

Bio‐fabrication and characterization of nano‐silver using Kickxia elatine plant and its anti‐diabetic effect on alloxan‐induced Sprague Dawley rats — An in vivo approach

Aspirin and meloxicam co-administration with leaf extract of Terminalia catappa; prevention of red blood cell related cardiovascular complications in alloxan induced diabetic rats

Quantitative susceptibility mapping for iron monitoring of multiple subcortical nuclei in type 2 diabetes mellitus: a systematic review and meta-analysis

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