Cross Linked Chitosan in Situ Gel of Satranidazole for Intra Periodontal Drug Delivery

Abstract

This paper introduces a novel type of injectable temperature-sensitive chitosan polymer based in situ gel for the local delivery of Satranidazole into the infected periodontal pocket. The thermo gelling polymer, chitosan with different concentrations has been used for formulation of in situ gel of Satranidazole with 10 % propylene glycol as plasticizer and was allowed to cross linked with 1 % solution of glutaraldehyde for extended release. The FTIR studies and the XRD studies confirmed the absence of chemical interaction between the drug and the polymer. The developed formulations were evaluated for various parameters like surface pH, gelation temperature, drug content, spreadability, viscosity, in vitro drug release and in vitro antibacterial activity, SEM and stability studies. The optimized formulation G6 in terms of cumulative percent drug release along with zero order kinetic mechanism with 98.6 % drug release for 5 days and fulfilled many requirements of once a week delivery system. Throughout the permeation study, the average permeation rate for in situ gel was found to be above the minimum inhibitory concentration of Satranidazole indicating the suitability of formulating Satranidazole as a controlled release local delivery in situ gel for longer periods of time. Histopathological and microscopic study of the periodontal mucosa after permeation study suggested that the gel formulations were safe for local anti microbial treatment in to the infected periodontal pocket. The in vitro antibacterial activity demonstrated a significant antibacterial profile of the in situ gel G6 formulation against Porphyromonas gingivalis. The SEM of in situ gel suggesting that the drug(s) were dispersed rather than dissolved in the polymer matrix. The stability studies confirmed that the in situ gel formulation of Satranidazole remained stable at room temperature (30 ± 2°C) and refrigerator temperature (4 ± 2°C).

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