Cross-Linked Guar Gum Hydrogel Discs for Colon-Specific Delivery of Ibuprofen: Formulation and In Vitro Evaluation

Das, Aditi; Wadhwa, Saurabh; Srivastava, Anand

doi:10.1080/10717540500313455

Cited by 71 publications

(23 citation statements)

References 12 publications

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“…Given the fact that modified polysaccharide has more stability against enzyme than its natural form, more attention has been paid, particularly to a cross-linked polysaccharide which is known to have a lower swelling property than its natural form [8,9]. Gliko-Kabir et al showed that the swelling property of guar gum was reduced significantly after being cross-linked with glutaraldehyde [10].…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Vitamin E Onto Cross-Linked Galactomannan Phosphate Matrix and in Vitro Study

Tarigan

Purba

Zuhra

2018

Asian J Pharm Clin Res

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Objective: This study demonstrated the incorporation of Vitamin E from palm fatty acid distillate onto crosslinked galactomannan phosphate (CGP) matrix.Methods: CGP was obtained from the crosslinking reaction of galactomannan from Arenga pinnata (GAP) with tri-sodium metaphosphate (TMF) ranging from 1:1 to 4:3 while incorporation of Vitamin E was conducted in two steps to form films. The reliability study of Vitamin E in CGPVE was conducted using a solution of pepsin and sodium chloride and also in solution of pancreatin and buffer phosphate. Results:The Fourier-transform infrared spectrum indicated the presence of phosphate in CGP while the scanning electron microscope images depicted the changes of surface morphology from smooth (GAP) to rough and hollow (CGP) which confirmed that crosslink had occurred. The swelling study of CGP showed that the swelling indexes were similar and decreased with the increase of TMF. The efficiency of CGP to absorb Vitamin E ranged from 89.66% to 91.09%. The in vitro releasing study of Vitamin E in simulated gastric fluid and simulated intestinal fluid showed that only a small amount of Vitamin E was released.Conclusions: This study demonstrated that CGP can be prepared and is potentially useful for drug delivery to the colon.

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Section: Introductionmentioning

confidence: 99%

Incorporation of Vitamin E Onto Cross-Linked Galactomannan Phosphate Matrix and in Vitro Study

Tarigan

Purba

Zuhra

2018

Asian J Pharm Clin Res

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“…Several hydrogels are currently being investigated as potential devices for colon-specific drug delivery. These include chemically or physically cross-linked polysaccharides, such as dextran, guar gum, azo cross-linked poly(acrylic acid), amidated pectin, and inulin [91][92][93]. They are designed to be highly swollen or degraded in the presence of colonic enzymes or microflora, providing colon specificity in drug delivery [94].…”

Section: Drug Delivery In the Gastrointestinal (Gi) Tractmentioning

confidence: 99%

Hydrogels in Regenerative Medicine

Budama‐Kilinc¹,

Çakır-Koç²,

Aslan³

et al. 2018

Biomaterials in Regenerative Medicine

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Polymer scaffolds have many various applications in the field of tissue engineering, drug delivery, and implantation. They are applied as dispensing devices for bioactive molecules and as three-dimensional (3D) structures that provide stimulants that organize cells and direct desired original tissue formation. Hydrogels are preferred scaffolding material because they are structurally similar to the extracellular matrix of many tissues, often processed under mild conditions, and can be delivered in a minimally invasive manner. Hydrogel materials formed a group of polymeric materials. The hydrophilic structure allows them to hold large amounts of water in their three-dimensional backbone. As a result, hydrogels are used as scaffolding material for drug and growth factor transmission, tissue engineering modifications, and many other applications. In this chapter, we describe the physical and chemical structure of hydrogels, side groups, cross-linkings, swelling properties, types of polymers and fabrication methods, and application fields.

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“…The main difference between them is that mucilage does not dissolve in water whereas gum dissolves in water and makes hydro-gel. Acacia, tragacanth, gum ghatti, gum karaya, and Ocimum bascilium are popular examples of plant mucilages with a demonstrate values in pharmaceutical applications (2,(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Supercritical CO2 Generation of Nanometric Structure from Ocimum basilicum Mucilage Prepared for Pharmaceutical Applications

2014

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Abstract. Plant-derived polymers are widely used in the pharmaceutical industry due to their emollient, lack of toxicity, and irritating nature and low cost. In this work, basil seed mucilage was dried using supercritical carbon dioxide phase inversion technique to form a nanometric structure. The obtained polymeric structures were characterized by scanning electron microscopy (SEM), Brunauer-EmmettTeller (BET) method, and Fourier transform infrared spectroscopy (FTIR) and compared with the ovenderived sample group. It was demonstrated that the product morphology could be controlled by altering the composition of methanol which functioned as the co-solvent in the nonsolvent stream. The most homogeneous product (60-nm mean pore size diameter, 78 m 2 /g BET surface area with no agglomeration) was obtained with 2.5% methanol. The FTIR data showed that the presence of hydroxyl and carboxyl groups suggested the bioadhesive property of basil seed mucilage was good and many active pharmaceutical compounds might be loaded to the resultant nanometric structure to enhance drug release. Furthermore, the FTIR analyses indicated that the nature of the final product did not change during the supercritical drying procedure.

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Cross-Linked Guar Gum Hydrogel Discs for Colon-Specific Delivery of Ibuprofen: Formulation and In Vitro Evaluation

Cited by 71 publications

References 12 publications

Incorporation of Vitamin E Onto Cross-Linked Galactomannan Phosphate Matrix and in Vitro Study

Incorporation of Vitamin E Onto Cross-Linked Galactomannan Phosphate Matrix and in Vitro Study

Hydrogels in Regenerative Medicine

Supercritical CO2 Generation of Nanometric Structure from Ocimum basilicum Mucilage Prepared for Pharmaceutical Applications

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