Cross-linked high amylose starch for controlled release of drugs: recent advances

Lenaerts, Vincent; Moussa, Iskandar S.; Dumoulin, Yves; Mebsout, F; Chouinard, François; Szabo, Pompilia Ispas; Mateescu, Mircea‐Alexandru; Cartilier, L.; Marchessault, R. H.

doi:10.1016/s0168-3659(97)00256-3

Cited by 111 publications

(67 citation statements)

References 8 publications

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“…More recently it was discovered that cross-linked starches possess unique features as an excipient for the manufacture of the controlled-release solid oral dosage form of drugs. 13,14 Chitosan has also been assessed for its potentiality in the development of controlled-release systems and for its propensity for targeting drugs to specific sites. 15,16 Numerous control or sustained delivery systems with chitosan have been described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Solid-state and mechanical properties of aqueous chitosan-amylose starch films plasticized with polyols

et al. 2004

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ABSTRACTagent, gel and emulsion agent, and most recently as a filmcoating agent. Higher molecular weight chitosans have been reported to have good film-forming properties as a result of intra-and intermolecular hydrogen bonding.2 The chitosan film characteristics, however, varied from one report to another. Differences in the sources of chitin used to produce chitosan, chitosan material properties, solvents used, methods of film preparation, and types and amounts of copolymers and plasticizers used may affect the quality of the films. 3-6The film-forming ability of chitosan and binary mixtures of chitosan and native amylose corn starch (Hylon VII) was evaluated with free films prepared by a casting/solvent evaporation method. Unplasticized and plasticized free chitosan films in aqueous acetic acid and respective films containing a mixture of chitosan and native amylose starch in acetic acid were prepared. Glycerol, sorbitol, and i-erythritol were used as plasticizers. Solid-state and mechanical properties of the films were studied by powder x-ray diffractometry (XPRD), differential scanning calorimetry (DSC), and a materials testing machine. The films composed of a mixture of chitosan and native amylose starch in acetic acid were clear and colorless. A plasticizer concentration of 20% wt/wt (of the polymer weight) was sufficient to obtain flexible films with all samples tested. X-ray diffraction patterns and DSC thermograms indicated an amorphous state of the films independent of the type of plasticizer used. In conclusion, incorporation of native amylose corn starch into chitosan films improves the consistency and the mechanical properties of the films.

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Section: Introductionmentioning

confidence: 99%

Solid-state and mechanical properties of aqueous chitosan-amylose starch films plasticized with polyols

et al. 2004

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“…Cross-linked high amylose starch (CLHAS) was introduced in the early 1990s as a tablet excipient for drug controlled release with the brand name Contramid Õ (Lenaerts et al, 1991(Lenaerts et al, , 1998Dumoulin et al, 1998). CLHAS is generally derived from the cross-linking of high amylose starch (70% amylose, 30% amylopectin) with epichlorohydrin or phosphate (Rahmouni et al, 2001).…”

Section: Cross-linked Starchmentioning

confidence: 99%

“…Compared to other excipients, CLHAS is more suitable for hydrophilic matrices preparation. The water uptake rate, drug release rate and equilibrium swelling are elevated with increasing crosslinking degree (cld), which is ascribed to the unique characteristics of CLHAS tablets, such as erosion resistance and swelling restriction (Lenaerts et al, 1998).…”

Section: Cross-linked Starchmentioning

confidence: 99%

“…( Lenaerts et al, 1998) Cross-link degree (cld) 1. The chains of low-cld CLA are closely located and stabilized by hydrogen bonding.…”

Section: Cross-linking Agents Summary Referencesmentioning

confidence: 99%

“…( Lenaerts et al, 1998) Grafted starch Graft copolymerization; drug type. (Casas et al, 2009, Marinich et al, 2012 A grafting chainderived acrylic layer led to enzymatic resistance and hydrophobic behavior.…”

Section: Influence Factors Summary Referencesmentioning

confidence: 99%

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Recent advances of starch-based excipients used in extended-release tablets: a review

Yan

Liu

2014

Drug Delivery

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In recent years, polysaccharides, including starch and its derivatives, have been widely used in the pharmaceutical industry, including as diluents, fillers, binders, disintegrants and glidants. The use of native starch as excipient in extended-release tablets is limited due to its low compactibility and enzymatic degradability, leading to the formation of weakly structured tablets. To overcome these limitations and expand the application of starch as an excipient, researchers have modified starch by physical and chemical methods, as well as by enzymatic hydrolysis. Some starch derivatives, including retrograded starch, pregelatinized starch, carboxymethyl starch, starch acetate, cross-linked starch and grafted starch have recently been introduced as excipients in oral tablets to control drug release. In this review, applications of starch and its derivatives as extended release excipients are reviewed and future frontiers are described.

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Preparation of amylose gel and probe diffusion through the gel membranes

Yasunaga

Matsumoto

Kitamura

2000

Macromol. Rapid Commun.

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Cross-linked high amylose starch for controlled release of drugs: recent advances

Cited by 111 publications

References 8 publications

Solid-state and mechanical properties of aqueous chitosan-amylose starch films plasticized with polyols

Solid-state and mechanical properties of aqueous chitosan-amylose starch films plasticized with polyols

Recent advances of starch-based excipients used in extended-release tablets: a review

Preparation of amylose gel and probe diffusion through the gel membranes

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