Cross-Linking and Corneal Imaging Advances

Kanellopoulos, Anastasios John; Krueger, Ronald R.; Asimellis, George

doi:10.1155/2015/306439

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…The clinical implications of the accuracy of these values is paramount, first considering that they are used clinically to define healthy from diseased, a task that we have previously reported on extensively. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Furthermore, refractive surgery both corneal and lens-based, and especially therapeutic-based refractive laser interventions, have long involved corneal, anterior chamber and pupillary imaging by evolving tomographic devices, as a means of customization of surgical accuracy and its effective assessment. We have also reported extensively on corneal imaging and specifically tomographic imaging used in naïve and/or irregular corneas as a customized-therapeutic surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

<p>Scheimpflug vs Scanning-Slit Corneal Tomography: Comparison of Corneal and Anterior Chamber Tomography Indices for Repeatability and Agreement in Healthy Eyes</p>

Kanellopoulos¹

2020

OPTH

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To evaluate and compare the repeatability and agreement of Scheimpflug vs scanning-slit tomography of the cornea and the anterior chamber in terms of keratometric and tomographic indices in healthy eyes. Methods: The 20 eyes of 10 healthy participants underwent 3 consecutive measurements using both Scheimpflug-tomography and scanning-slit tomography, diagnostic devices. Multiple corneal and anterior chamber tomographic parameters were recorded and evaluated to include corneal keratometry and its axis; corneal best-fit sphere (BFS), pachymetry mapping, angle kappa, anterior chamber depth (ACD), pupil diameter, and location. Repeatability for each device was assessed using the within each subject standard deviation of sequential exams, the coefficient variation (CV) and the intraclass correlation coefficient (ICC). Agreement between the two devices was assessed using Bland-Altman plots with 95% limits of agreement (LoA) and correlation coefficient (r). Results: Both devices were found to have high repeatability (ICC>0.9) both in keratometric and other tomographic measurements. Scheimpflug tomography's repeatability though appeared superior in the average keratometry values, anterior and posterior BFS, thinnest corneal pachymetry value and location (p<0.05). Agreement: Statistically significant interdevice differences were noted in the mean values of K1, K2, BFS, ACD and thinnest corneal pachymetry (p<0.05). Despite the agreement differences noted, the two devices were well correlated (r>0.8) in respective measurements with Scheimpflug delivering consistently lower values than the scanning-slit tomography device. Conclusion: Scheimpflug-tomography repeatability was found to be superior to that of scanning-slit tomography in this specific study, in most parameters evaluated. Inter-device agreement evaluation suggests that reading from the two devices may not be used interchangeably in absolute values, yet they are well correlated with Scheimpflug delivering consistently lower values in most.

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Section: Introductionmentioning

confidence: 99%

<p>Scheimpflug vs Scanning-Slit Corneal Tomography: Comparison of Corneal and Anterior Chamber Tomography Indices for Repeatability and Agreement in Healthy Eyes</p>

Kanellopoulos¹

2020

OPTH

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Principles of Accelerated Corneal Collagen Cross-Linking

Mazzotta

Raiskup

Baiocchi

et al. 2017

Management of Early Progressive Corneal Ectasia

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Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty

Alzahrani

Dardin

Carley

et al. 2018

OPTH

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PurposeTo compare the corneal clarity measurement between penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) in patients with keratoconus, using densitometry software for the Oculus Pentacam.MethodsA retrospective comparative study was carried out at Manchester Royal Eye Hospital. Data were collected 12–18 months after corneal transplantation for keratoconus, including postoperative corneal densitometry, best corrected visual acuity (BCVA), central corneal thickness (CCT), and other relevant clinical details.ResultsAnalysis of 37 keratoconus eyes from 36 patients found there was a significantly higher corneal densitometry measurement after DALK than PK. This was predominantly in the posterior layer of the concentric zone 0–2 mm of the cornea (P=0.0004). A significant correlation was found between postoperative BCVA and corneal densitometry in DALK groups at full thickness (P=0.03). This correlation was seen in the central 0–2 mm (P=0.03) and posterior 0–2 mm (P=0.04) zones. In addition, within the DALK group, a correlation was found between central corneal thickness and densitometry at full thickness 2–6 mm (P=0.007), central 0–2 (P=0.04), central 2–6 mm (P=0.01), and at posterior 2–6 mm (P=0.01) zones.ConclusionThis study showed that corneal densitometry measurement differs depending on the type of corneal transplantation used to treat keratoconus patients. Densitometry may have an important role to play in the final BCVA achieved by patients undergoing corneal transplantation for keratoconus. Analysis of Oculus Pentacam images provides an objective evaluation to monitor the cornea status after the surgery.

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Cross-Linking and Corneal Imaging Advances

Cited by 3 publications

References 9 publications

<p>Scheimpflug vs Scanning-Slit Corneal Tomography: Comparison of Corneal and Anterior Chamber Tomography Indices for Repeatability and Agreement in Healthy Eyes</p>

<p>Scheimpflug vs Scanning-Slit Corneal Tomography: Comparison of Corneal and Anterior Chamber Tomography Indices for Repeatability and Agreement in Healthy Eyes</p>

Principles of Accelerated Corneal Collagen Cross-Linking

Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty

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