Cross-Modal Stochastic Resonance as a Universal Principle to Enhance Sensory Processing

Krauß, Patrick; Tziridis, Konstantin; Schilling, Achim; Schulze, Holger

doi:10.3389/fnins.2018.00578

Cited by 62 publications

(90 citation statements)

References 46 publications

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“…5, right panel) which is in line with the increased activity in the medial geniculate body (MGb) reported after noise exposure (Kalappa et al, 2014). It seems likely that increased thalamic activation of ACx is the result of mechanisms of compensatory, homeostatic plasticity (Mossop et al, 2000;Schaette and Kempter, 2006;Noreña, 2011;Tighilet et al, 2016) or stochastic resonance (Krauss et al, 2016(Krauss et al, , 2018 within the subcortical auditory pathway (Eggermont, 2017a). This conclusion is further supported by our layerspecific analysis, demonstrating that early sink activity in both thalamocortical-recipient layers III/IV and Vb/VIa was significantly increased after recovery (Fig.…”

Section: Chronic Effects Of Sound Trauma On Circuit-level Activity Insupporting

confidence: 67%

Acute and long-term circuit-level effects in the auditory cortex after sound trauma

Jeschke

Happel

Tziridis

et al. 2020

Preprint

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Harmful environmental sounds are a prevailing source for chronic hearing impairments, including noise induced hearing loss, hyperacusis, or tinnitus. How these symptoms are related to pathophysiological damage to the sensory receptor epithelia and its effects along the auditory pathway, such as functional reorganizations in the auditory cortex (ACx), have been documented in numerous studies. An open question concerns the temporal evolution of maladaptive changes after damage and their manifestation in the balance between afferent thalamocortical input and corticocortical input to the ACx.To address this, we investigated the loci of plastic reorganizations across the tonotopic axis of the auditory cortex of male Mongolian gerbils (Meriones unguiculatus) acutely after a sound trauma and after several weeks. We used a laminar residual current-source density analysis to dissociate adaptations of intracolumnar input and horizontally relayed corticocortical input to synaptic populations across cortical layers in ACx. A pure tone-based sound trauma caused acute changes of subcortical inputs and corticocortical inputs at all tonotopic regions, particularly showing a broad elimination of tone-evoked inputs at tonotopic regions with a pre-trauma best frequency between 2-8 kHz. At other cortical sites, the overall columnar activity acutely decreased, while relative contributions of lateral corticocortical inputs increased. After 4-6 weeks, cortical activity to the altered sensory inputs showed a general increase of local thalamocortical input reaching levels higher than before the trauma. Hence, our results suggest a detailed mechanism for overcompensation of altered frequency input in the auditory cortex that relies on a changing balancing of thalamocortical and intracortical input and is confined to the spectral neighborhood of the trauma frequency. Significance statementHarmful noise exposure is a major anthropogenic cause of hearing disorders and is becoming an everincreasing burden for human health and society. Damage to the sensory epithelia elicited by harmful sounds can subsequently lead to chronic hearing loss, hyperacusis or tinnitus. We still lack an understanding of the pathophysiological plastic processes and their evolution, particularly at the circuit level of the auditory cortex (ACx), which is fundamentally involved in auditory perception. We demonstrate that plastic changes in ACx after noise induced hearing loss (NIHL) occur over several weeks, and that changes in intracortical functional connectivity compensate the acute effects in the deafferentiated subcortical inputs. Such longterm changes may underlie the temporal evolution of hearing impairments or phantom sounds after NIHL.

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Section: Chronic Effects Of Sound Trauma On Circuit-level Activity Insupporting

confidence: 67%

Acute and long-term circuit-level effects in the auditory cortex after sound trauma

Jeschke

Happel

Tziridis

et al. 2020

Preprint

Self Cite

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“…Our idea that cross-modal SR, with cochlear inputs being the signal and somatosensory projections being the noise (Figure 2), is a key processing principle of the auditory system and actually takes place in the DCN (Krauss et al, 2018) is supported by a large number of different findings. For instance, it is well known, that jaw movements lead to a modulation of subjective tinnitus loudness (Pinchoff et al, 1998).…”

Section: Tinnitus Developmentmentioning

confidence: 89%

“…In a number of recently published studies, we demonstrated theoretically and empirically that SR might be a major processing principle of the auditory system that serves to partially compensate for acute or chronic hearing loss (Krauss et al, 2016(Krauss et al, , 2018(Krauss et al, , 2019b. According to our model, the noise required for SR is generated within the brain and then perceived as a phantom sound.…”

Section: Tinnitus Developmentmentioning

confidence: 99%

“…From this point of view, auditory phantom perceptions like tinnitus (or even the Zwicker tone, cf. below) seem to be a side effect of an adaptive mechanism within the auditory system whose primary purpose is to compensate for reduced input through continuous optimization of information transmission (Krauss et al, 2016(Krauss et al, , 2018(Krauss et al, , 2019b. This new interpretation may also explain why auditory sensitivity is increased in tinnitus ears (Hebert et al, 2013;: the increased amount of neural noise during tinnitus improves auditory sensitivity by means of SR.…”

Section: Tinnitus Developmentmentioning

confidence: 99%

“…In addition, DCN responses to somatosensory stimulation are enhanced after noiseinduced hearing loss Shore 2011;Wu et al, 2016). Therefore, we previously proposed the possibility that the neural noise which is necessary for SR is injected into the auditory system via somatosensory projections to the DCN (Krauss et al, 2016(Krauss et al, , 2018(Krauss et al, , 2019b, and that these non-auditory projections into the DCN are the cause of the altered "spontaneous activity" within the DCN after hearing loss described previously (Gao et al, 2016). From an information processing point of view, somatosensory inputs are completely uncorrelated, i.e.…”

Section: Tinnitus Developmentmentioning

confidence: 99%

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The Stochastic Resonance model of auditory perception: A unified explanation of tinnitus development, Zwicker tone illusion, and residual inhibition

Schilling

Tziridis

Schulze

et al. 2020

Preprint

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Stochastic Resonance (SR) has been proposed to play a major role in auditory perception, and to maintain optimal information transmission from the cochlea to the auditory system. By this, the auditory system could adapt to changes of the auditory input at second or even subsecond timescales. In case of reduced auditory input, somatosensory projections to the dorsal cochlear nucleus would be disinhibited in order to improve hearing thresholds by means of SR. As a side effect, the increased somatosensory input corresponding to the observed tinnitus-associated neuronal hyperactivity is then perceived as tinnitus. In addition, the model can also explain transient phantom tone perceptions occurring after ear plugging, or the Zwicker tone illusion. Vice versa, the model predicts that via stimulation with acoustic noise, SR would not be needed to optimize information transmission, and hence somatosensory noise would be tuned down, resulting in a transient vanishing of tinnitus, an effect referred to as residual inhibition.

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The Universal Multilevel Relationship Between the Stochastic Organization of Genomes and the Deterministic Structure of DNA Alphabets

Petoukhov

2022

Advances in Intelligent Systems, Computer Science and Digital Economics III

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Cross-Modal Stochastic Resonance as a Universal Principle to Enhance Sensory Processing

Cited by 62 publications

References 46 publications

Acute and long-term circuit-level effects in the auditory cortex after sound trauma

Acute and long-term circuit-level effects in the auditory cortex after sound trauma

The Stochastic Resonance model of auditory perception: A unified explanation of tinnitus development, Zwicker tone illusion, and residual inhibition

The Universal Multilevel Relationship Between the Stochastic Organization of Genomes and the Deterministic Structure of DNA Alphabets

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