Cross-regulation between CDK and MAPK control cellular fate

Durandau, Eric; Pelet, Serge

doi:10.1101/274787

Cited by 1 publication

(1 citation statement)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MAPK can modulate cell-cycle arrest [ 81 ]. MAPK is also tightly regulated with cyclin-dependent kinase (CDK) to control cell-cycle progression [ 82 ].…”

Section: Oxidative Stress Modulates Cell Functionsmentioning

confidence: 99%

The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products

et al. 2022

View full text Add to dashboard Cite

Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating several cell functions of cancer cells. Several natural products modulate both oxidative stress and AKT for anticancer effects. However, the impact of natural product-modulating oxidative stress and AKT on cell functions lacks systemic understanding. Notably, the contribution of regulating cell functions by AKT downstream effectors is not yet well integrated. This review explores the role of oxidative stress and AKT pathway (AKT/AKT effectors) on ten cell functions, including apoptosis, autophagy, endoplasmic reticulum stress, mitochondrial morphogenesis, ferroptosis, necroptosis, DNA damage response, senescence, migration, and cell-cycle progression. The impact of oxidative stress and AKT are connected to these cell functions through cell function mediators. Moreover, the AKT effectors related to cell functions are integrated. Based on this rationale, natural products with the modulating abilities for oxidative stress and AKT pathway exhibit the potential to regulate these cell functions, but some were rarely reported, particularly for AKT effectors. This review sheds light on understanding the roles of oxidative stress and AKT pathway in regulating cell functions, providing future directions for natural products in cancer treatment.

show abstract

“…MAPK can modulate cell-cycle arrest [ 81 ]. MAPK is also tightly regulated with cyclin-dependent kinase (CDK) to control cell-cycle progression [ 82 ].…”

Section: Oxidative Stress Modulates Cell Functionsmentioning

confidence: 99%