Cross-sectional analysis between prostate volumes and serum sex hormones in Japanese men attending a urological clinic

Nukui, Masanori; Takada, Hitosi; Nakagawa, Shuichi

doi:10.3109/13685538.2016.1162783

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…However, after adjusting for age, the results were not statistically significant 13 . In contrast, Nukui M et al 35 found that PV was positively correlated with TT, but this finding only existed in groups with PV > 25 ml in a cross-sectional study of 226 subjects. Other studies have also failed to find a significant association between TT level and PV 12 , 14 .…”

Section: Discussionmentioning

confidence: 81%

Relationship between serum total testosterone and prostate volume in aging men

Xia

Zhao

Chen

et al. 2021

Sci Rep

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Total testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs. 24.06 ± 6.77 P = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all P < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (P = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.

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Section: Discussionmentioning

confidence: 81%

Relationship between serum total testosterone and prostate volume in aging men

Xia

Zhao

Chen

et al. 2021

Sci Rep

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“…In present study, Tai Chi participants have significant higher ratio of DHEA to total testosterone not to free testosterone. However, the ratio of DHEAS to testosterone is reported negatively correlated to prostate volume (23). Moreover, Tai Chi training in patients with innocuous prostate hypertrophy is able to improve lower urinary tract symptoms as well as qual- Well-being encompasses not only the physical body but also the spiritual, mental and emotional parts of an individual's life.…”

Section: Discussionmentioning

confidence: 99%

Higher DHEAS Levels Associated with Long-Term Practicing of Tai Chi

Lai

Liu²,

Lin

et al. 2017

Chin. J. Physiol.

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Tai Chi has many benefits for middle-aged/older individuals including improvements to muscle strength and various body lipid components. DHEAS and testosterone have anti-obesity/anti-aging characteristics and also improve libido, vitality and immunity levels. Thus, the aim of the present study was to investigate the differences between middle-aged Tai Chi practitioners (n = 17) and sedentary individuals (n = 17) in terms of leg strength, blood levels of cholesterol, triglyceride, HDL, as well as DHEAS, testosterone and cortisol. Unpaired t-tests were used to identify significant differences between the two groups. There were no significant differences in body composition, leg strength, blood lipid components and testosterone. However, the Tai Chi practitioners had higher levels of DHEAS (P< 0.01) and lower levels of cortisol (P< 0.05). Thus, Tai Chi practitioners have a higher ratio of DHEAS to cortisol, which might have potential benefits in terms of improving an individual’s health-related quality of life during the aging.

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“…The prostate gland (PG) is an exocrine gland tightly influenced by the endocrine milieu, as its development and homeostasis is regulated, for instance, by sexual hormones. Indeed, testosterone, the main sexual hormone responsible for prostate homeostasis, can be locally converted to dihydrotestosterone, which is involved in increasing proliferation and reducing death of PG cells . Moreover, a growing body of evidence indicates that the endocrine axis comprising growth hormone (GH), insulin and insulin‐like growth factor 1 (IGF1) is locally expressed in the PG and plays a relevant role in its pathophysiology .…”

Section: Introductionmentioning

confidence: 99%

Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1

L‐López

Sarmento‐Cabral

Herrero‐Aguayo

et al. 2017

J Cellular Molecular Medi

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Obesity is a major health problem that courses with severe comorbidities and a drastic impairment of homeostasis and function of several organs, including the prostate gland (PG). The endocrine–metabolic regulatory axis comprising growth hormone (GH), insulin and IGF1, which is drastically altered under extreme metabolic conditions such as obesity, also plays relevant roles in the development, modulation and homeostasis of the PG. However, its implication in the pathophysiological interplay between obesity and prostate function is still to be elucidated. To explore this association, we used a high fat–diet obese mouse model, as well as in vitro primary cultures of normal‐mouse PG cells and human prostate cancer cell lines. This approach revealed that most of the components of the GH/insulin/IGF1 regulatory axis are present in PGs, where their expression pattern is altered under obesity conditions and after an acute insulin treatment (e.g. Igfbp3), which might have some pathophysiological implications. Moreover, our results demonstrate, for the first time, that the PG becomes severely insulin resistant under diet‐induced obesity in mice. Finally, use of in vitro approaches served to confirm and expand the conception that insulin and IGF1 play a direct, relevant role in the control of normal and pathological PG cell function. Altogether, these results uncover a fine, germane crosstalk between the endocrine–metabolic status and the development and homeostasis of the PG, wherein key components of the GH, insulin and IGF1 axes could play a relevant pathophysiological role.

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Cross-sectional analysis between prostate volumes and serum sex hormones in Japanese men attending a urological clinic

Cited by 7 publications

References 26 publications

Relationship between serum total testosterone and prostate volume in aging men

Relationship between serum total testosterone and prostate volume in aging men

Higher DHEAS Levels Associated with Long-Term Practicing of Tai Chi

Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1

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