Cross-Sensitivity between Paroxetine and Sertraline

Warnock, Caroline A; Azadian, Abbas

doi:10.1345/aph.1a262

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…Cross‐sensitivity among different SSRIs has been suggested as some reports have described cutaneous eruptions experienced by the same patients to two or more of these drugs (5). It may be related to a shared mechanism of action or to a common excipient.…”

Section: Discussionmentioning

confidence: 99%

Erythema multiforme photoinduced by paroxetine and herpes simplex virus

Rodríguez-Pazos

Gómez-Bernal

Montero

et al. 2011

Photoderm Photoimm Photomed

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Erythema multiforme (EM) is a self-limited skin disease, characterized by the abrupt onset of symmetric red papules that may evolve into target lesions often precipitated by an infection. Photosensitive erythema multiforme (PEM) is a rare disorder characterized by the distribution of the lesions on sun-exposed areas. It has been described at the sites of sunburn, following episodes of polymorphic light eruption or herpes labialis and in association with drugs. To our knowledge, PEM photoinduced by selective serotonin reuptake inhibitors has not been reported. We describe a patient who had two consecutive episodes of PEM related to two different triggers: paroxetine and HSV infection. In the first episode, systemic photosensitivity was confirmed with the photobiological study. UVB-MED was decreased when the patient was taking paroxetine and did not change after its substitution for duloxetine. However, it became normal after the withdrawal of both drugs, suggesting a cross-reactivity reaction. The UVB photopatch test with paroxetine was positive. The second episode occurred after a herpes labialis relapse. At that time, UVB-MED was normal.

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Section: Discussionmentioning

confidence: 99%

Erythema multiforme photoinduced by paroxetine and herpes simplex virus

Rodríguez-Pazos

Gómez-Bernal

Montero

et al. 2011

Photoderm Photoimm Photomed

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“…[10] The cross-sensitivity among them has been uncommonly reported between paroxetine and sertraline. [78] Our case is of particular interest because in the previous two reports rash was initially noted first on exposure to paroxetine followed by sertraline; however, reverse scenario has been seen in our patient who may have experienced an adverse drug reaction and possible cross-reactivity, since paroxetine was started after 10 days of sertraline discontinuation while the usual washout time for sertraline is about 7 days (The half-life of sertraline is approximately 25 h; and it has a less potently active metabolite with half life of 60 to 70 h). [12] The chronology of events suggested that both reactions were caused by the SSRIs, suggesting a class effect although the confirmative validative patch test could not be done due to patient's refusal.…”

Section: Discussionmentioning

confidence: 99%

“…A computerized MEDLINE search on the above subject yielded a report of two cases of possible cross-sensitivity between SSRIs, and in both the cases paroxetine was involved. [78]…”

Section: Introductionmentioning

confidence: 99%

Possible cross-sensitivity between sertraline and paroxetine in a panic disorder patient

et al. 2010

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Cross-sensitivity due to paroxetine and sertraline, the SSRIs, is rarely reported in the literature. We report an adverse drug reaction to paroxetine and sertraline in a patient of panic disorder, who initially developed a maculopapular, erythematous, pruritic rash in the third week with sertraline 50 mg/day. The rash resolved within 2 days of its discontinuation and oral supplementation of diphenhydramine and betamethasone. 10 days following discontinuation of sertraline, the patient was shifted on sustain release paroxetine 12.5 mg/day when another skin reaction with the same appearance and distribution appeared on day 4 of it, suggesting a possibility of cross-sensitivity, a drug class effect. This case report intends to improve the awareness among clinicians to use caution when choosing an alternative SSRIs.

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“…There are a few reports of rashes developing during SSRI treatment (Charbonnier et al, 1987;Koran et al, 2003;Sannicandro et al, 2002;Spigset, 1999;Thedenat et al, 2001;Warnock and Azadian, 2002). and there are also case reports of allopecia in patients on SSRIs (Mercke et al, 2000).…”

Section: Side-effect Profilementioning

confidence: 99%

Monoaminergic‐based Pharmacotherapy for Depression

Papakostas¹,

Fava²

2005

Biology of Depression

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Although recent advances in neuropharmacology, neuroendocrinology, molecular biology, and pharmacogenetics have been instrumental in bringing about potential treatments for depression which are fundamentally unrelated to their predecessors, including substance P antagonists, glutaminergic agents, and corticotropinreleasing factor (CRF) antagonists, nevertheless it was agents that influenced the function of monoamine receptors and transporters that were discovered initially by serendipity and then developed as treatments for depression. The development of such compounds also served as a framework for the understanding of depression as a medical illness affecting brain functioning. As a result of these efforts, our field has gained further understanding of the role of monoamines in depression. In previous chapters, the relevance of monoamines in the underlying pathophysiology of depression was reviewed. In the following chapter we will focus on describing the contemporary role of monoaminergic agents in the treatment of depression. 6.

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Cross-Sensitivity between Paroxetine and Sertraline

Abstract: The possibility of cross-reactivity between SSRI antidepressants should be considered by clinicians who wish to switch from one SSRI to another due to a dermatologic reaction.

Cited by 10 publications

References 3 publications

Erythema multiforme photoinduced by paroxetine and herpes simplex virus

Erythema multiforme photoinduced by paroxetine and herpes simplex virus

Possible cross-sensitivity between sertraline and paroxetine in a panic disorder patient

Monoaminergic‐based Pharmacotherapy for Depression

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