Cross‐sensitization between testosterone and cocaine in adolescent and adult rats

Engi, Sheila A.; Cruz, Fábio C.; Crestani, Carlos C.; Planeta, Cleópatra da Silva

doi:10.1016/j.ijdevneu.2015.07.001

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…In our study, we observed cross-sensitization in adolescent, but not in adult rats. Our results corroborated our previous study showing cross-sensitization between testosterone and cocaine in adolescent, but not in adult rats ( 22 ). However, in that study we used different groups for adolescent and adult rats.…”

Section: Discussionsupporting

confidence: 93%

“…Despite the importance, little is known about the effects of chronic testosterone administration on psychoactive substance behavior, including ATS. In fact, previous results from our laboratory showed that the chronic treatment with testosterone caused an increase in the cocaine stimulant effect in adolescent and adult rats, and locomotor cross-sensitization in adolescent rats ( 22 ). Therefore, a question to be answered is whether chronic testosterone use could promote cross-sensitization to amphetamine derivatives in adolescent and adult rats.…”

Section: Introductionmentioning

confidence: 89%

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Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats

Conceicao

Engi

Cruz

et al. 2018

Braz J Med Biol Res

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The abuse of psychoactive drugs is considered a global health problem. During the last years, a relevant number of studies have investigated the relationship between anabolic-androgenic steroids (AAS) and other psychoactive drugs. AAS, such as testosterone, can cause a dependence syndrome that shares many features with the classical dependence to psychoactive substances. Pre-clinical evidence shows that there are interactions between testosterone and psychoactive drugs, such as cocaine. However, few studies have been performed to investigate the effect of repeated testosterone treatment on behavioral effects of amphetamine derivatives, such as fenproporex. The purpose of the present study was to investigate the effects of repeated testosterone administration on fenproporex-induced locomotor activity in adolescent and adult rats. Adolescent male Wistar rats were injected with testosterone (10 mg/kg sc for 10 days). After 3 days, animals received an acute injection of fenproporex (3.0 mg/kg ip) and the locomotor activity was recorded during 40 min. Thirty days later, the same animals received the same treatment with testosterone followed by a fenproporex challenge injection as described above. Our results demonstrated that repeated testosterone induced behavioral sensitization to fenproporex in adolescent but not in adult rats. These findings suggest that repeated AAS treatment might increase the dependence vulnerability to amphetamine and its derivatives in adolescent rats.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 89%

Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats

Conceicao

Engi

Cruz

et al. 2018

Braz J Med Biol Res

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“…Furthermore, animal research has suggested that adolescents may be particularly sensitive to the effects of testosterone on reward systems. For instance, in rodent models, repeated administration of testosterone sensitizes adolescent male animals, but not adult males, to the locomotor effects of cocaine, a process that is dependent on changes in dopamine neurotransmission (Engi, Cruz, Crestani, & Planeta, 2015). Neuroendocrine research in animal models, therefore, has supported the possibility that gonadal hormone change will impact reward sensitivity and consequently sensation seeking.…”

Section: Are Developmental Differences In Reward Sensitivity and Sens...mentioning

confidence: 99%

Developmental differences in reward sensitivity and sensation seeking in adolescence: Testing sex-specific associations with gonadal hormones and pubertal development.

Harden¹,

Mann²,

Grotzinger³

et al. 2018

Journal of Personality and Social Psychology

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Sensation seeking has been found to increase, on average, from childhood to adolescence. Developmental scientists have hypothesized that this change could be driven by the rise of gonadal hormones at puberty, which affect reward-related processing in the brain. In a large, age-heterogeneous, population-based sample of adolescents and young adults (N = 810; ages 13-20 years), we tested for sex-specific associations between age, self-reported pubertal development, gonadal hormones (estradiol and testosterone) as measured in saliva, reward sensitivity as measured by a multivariate battery of in-laboratory tasks (including the Iowa gambling task, balloon analogue risk task, and stoplight task), and self-reported sensation seeking. Reward sensitivity was more strongly associated with sensation seeking in males than females. For both males and females, reward sensitivity was unrelated to age but was higher among those who reported more advanced pubertal development. There were significant sex differences in the effects of self-reported pubertal development on sensation seeking, with a positive association evident in males but a negative association in females. Moreover, gonadal hormones also showed diverging associations with sensation seeking-positive with testosterone but negative with estradiol. Overall, the results indicate that sensation seeking among adolescents and young adults depends on a complex constellation of developmental influences that operate via sex-specific mechanisms. (PsycINFO Database Record

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“…Evidence suggests that dopamine is the substrate involved in this process (Kalivas and Stewart, 1991). Studies found that androgens like testosterone induce cross sensitization to cocaine in prepubertal, but not in adult male rats (Engi et al, 2015).…”

Section: Aas and Cocainementioning

confidence: 99%

Nandrolone alters the behavioral response to cocaine as well as striatal and cortical dopamine receptors of prepubertal male rats

Freire-Arvelo,

Rivero,

Santiago-Marrero

et al. 2024

Preprint

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Nandrolone is the anabolic androgenic steroid (AAS) most used by athletes and adolescents. The use of supraphysiologic doses has been associated with dysfunction in brain areas that regulate anxiety, motivation, and reward. This study investigated if exposure to nandrolone before puberty altered anxiety- and addictive-like behaviors. Changes in dopamine type 2 receptors (D2DR) in the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) were also examined. Male rats received 10 daily injections of nandrolone decanoate (20 mg/kg) starting on day 28. Afterwards, they were tested in the elevated plus maze (EPM) and open field (OF). Their locomotor response (sensitization) and preference (conditioned place preference (CPP)) to cocaine (15 mg/kg) was also assessed. Nandrolone reduced anxiety and ambulation. Nandrolone-treated males also displayed sensitization to cocaine at an earlier age (day 44) than oil-treated males (day 52) and showed a 27% reduction in CPP to cocaine. Expression of D2DR in the NAc, and in the PFC of males tested for CPP was increased by nandrolone, whereas treatment with cocaine reduced accumbal D2DR. We hypothesize that nandrolone accelerates the development of the neural circuitry that regulates behavioral sensitization and reduces the rewarding property of cocaine, as manifested in the reduction of CPP. It is possible that the observed increase in accumbal D2DR may partially mediate the reduced anxiety and ambulation as well accelerate the maturation of the neural circuitry responsible for the sensitized response to cocaine.

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Cross‐sensitization between testosterone and cocaine in adolescent and adult rats

Cited by 4 publications

References 33 publications

Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats

Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats

Developmental differences in reward sensitivity and sensation seeking in adolescence: Testing sex-specific associations with gonadal hormones and pubertal development.

Nandrolone alters the behavioral response to cocaine as well as striatal and cortical dopamine receptors of prepubertal male rats

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