Cross-species analysis of transcriptome emphasizes a critical role of TNF-α in mediating MAP2K7/AKT2 signaling in zearalenone-induced apoptosis

Zhang, Fa‐Li; Zhu, Ke-Xin; Wang, Jingya; Guo, Huiling; Yan, Jia-Mao; Liu, Qingchun; Zhang, Xiaoyuan; Guo, Jun; Li, Xuan; Sun, Qiu; Ge, Wei; Li, Lan; Shen, Wei

doi:10.1016/j.jhazmat.2023.132226

Cited by 7 publications

(2 citation statements)

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“…Zearalenone (ZEN) is a metabolite produced by fusarium. It is a common pollutant in cereals such as corn, wheat, oats, etc. − Meanwhile, ZEN has hepatotoxicity, immunotoxicity, teratogenicity, and carcinogenicity, posing a great threat to human health. ,, The International Agency for Research on Cancer classified it as a Group III carcinogen. , There are several methods available for ZEN detection, such as high-performance liquid chromatography, gas chromatography–mass spectrometry, ultra-performance liquid chromatography/tandem mass spectrometry, , and enzyme-linked immunosorbent assay. , But these methods require expensive equipment, skilled operators, and so on . Consequently, it is urgently necessary to develop a simple operation, low-cost, and easy-to-control approach for ZEN detection.…”

Section: Introductionmentioning

confidence: 99%

“…1−3 Meanwhile, ZEN has hepatotoxicity, immunotoxicity, teratogenicity, and carcinogenicity, posing a great threat to human health. 1,4,5 The International Agency for Research on Cancer classified it as a Group III carcinogen. 6,7 There are several methods available for ZEN detection, such as highperformance liquid chromatography, 8 gas chromatography− mass spectrometry, 9 ultra-performance liquid chromatography/tandem mass spectrometry, 10,11 and enzyme-linked immunosorbent assay.…”

Section: ■ Introductionmentioning

confidence: 99%

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Solvent Regulation Induced Cathode Aggregation-Induced Electrochemiluminescence of Tetraphenylethylene Nanoaggregates for Ultrasensitive Zearalenone Analysis

Chen,

Pan,

Cao

et al. 2024

Anal. Chem.

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Zearalenone (ZEN) is an extremely hazardous chemical widely existing in cereals, and its high-sensitivity detection possesses significant significance to human health. Here, the cathodic aggregation-induced electrochemiluminescence (AIECL) performance of tetraphenylethylene nanoaggregates (TPE NAs) was modulated by solvent regulation, based on which an electrochemiluminescence (ECL) aptasensor was constructed for sensitive detection of ZEN. The aggregation state and AIECL of TPE NAs were directly and simply controlled by adjusting the type of organic solvent and the fraction of water, which solved the current shortcomings of low strength and weak stability of the cathode ECL signal for TPE. Impressively, in a tetrahydrofuran–water mixed solution (volume ratio, 6:4), the relative ECL efficiency of TPE NAs reached 16.03%, which was 9.2 times that in pure water conditions, and the maximum ECL spectral wavelength was obviously red-shifted to 617 nm. In addition, “H”-shape DNA structure-mediated dual-catalyzed hairpin self-assembly (H-D-CHA) with higher efficiency by the synergistic effect between the two CHA reactions was utilized to construct a sensitive ECL aptasensor for ZEN analysis with a low detection limit of 0.362 fg/mL. In conclusion, solvent regulation was a simple and efficient method for improving the performance of AIECL materials, and the proposed ECL aptasensor had great potential for ZEN monitoring in food safety.

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