Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies

Ahmad, Khurshid; Shaikh, Sibhghatulla; Ahmad, Syed Sayeed; Lee, Eun Ju; Choi, Inho

doi:10.3389/fphar.2020.00142

Cited by 45 publications

(43 citation statements)

References 86 publications

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“…In support of this finding, the relevant role of ECM in maintaining the structure and integrity of skeletal muscle is widely described in the literature. Indeed, ECM is essential for tissue architecture and for regulating intercellular communications 25 . Alterations in key components of the ECM can lead to muscular abnormalities, as proven for muscular dystrophies in humans 26 .…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, laminins are the main non-collagenous glycoprotein constituting the basement membrane (BM) 28 . This type of glycoproteins is known to be involved in myoblast proliferation and differentiation, and to be associated with myopathies in humans 25 . In particular, mutations in LAMA2 result in a type of muscular congenital dystrophy: the “Laminin-α2 chain-deficient congenital muscular dystrophy” or “LAMA2-CMD” 29 , 30 .…”

Section: Discussionmentioning

confidence: 99%

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Weighted gene co-expression network analysis identifies molecular pathways and hub genes involved in broiler White Striping and Wooden Breast myopathies

Bordini

Zappaterra

Soglia

et al. 2021

Sci Rep

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In recent years, the poultry industry has experienced an increased incidence of myopathies affecting breasts of fast-growing broilers, such as White Striping (WS) and Wooden Breast (WB) defects. To explore the molecular mechanisms and genes involved in WS and WB onset, we decided to perform a Weighted Gene Co-expression Network Analysis (WGCNA) using the gene expression profile and meat quality parameters of Pectoralis major muscles analysed in our previous study. Among the 212 modules identified by WGCNA, the red, darkred, midnightblue and paleturquoise4 modules were chosen for subsequent analysis. Functional analysis evidenced pathways involved in extracellular matrix (ECM) organization, collagen metabolism, cellular signaling and unfolded protein response. The hub gene analysis showed several genes coding for ECM components as the most interconnected nodes in the gene network (e.g. COL4A1, COL4A2, LAMA2, LAMA4, FBLN5 and FBN1). In this regard, this study suggests that alterations in ECM composition could somehow activate the cascade of biological reactions that result in the growth-related myopathies onset, and the involvement of Collagen IV alterations in activating the endoplasmic reticulum (ER) stress response may be hypothesized. Therefore, our findings provide further and innovative knowledge concerning the molecular mechanisms related to the breast abnormalities occurrence in modern broilers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Weighted gene co-expression network analysis identifies molecular pathways and hub genes involved in broiler White Striping and Wooden Breast myopathies

Bordini

Zappaterra

Soglia

et al. 2021

Sci Rep

View full text Add to dashboard Cite

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“…Duchenne muscular dystrophy (DMD) is a form of muscular dystrophy associated with X-linked recessive disorder caused by mutation of dystrophin in SM [72,73]. DMD shows a male predominance and causes muscle degeneration.…”

Section: Role Of Igf-1 In Duchenne Muscular Dystrophymentioning

confidence: 99%

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Ahmad

Lee

et al. 2020

Cells

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117

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Skeletal muscle is an essential tissue that attaches to bones and facilitates body movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an important role in skeletal myogenesis and is importantly associated with muscle mass entity, strength development, and degeneration and increases the proliferative capacity of muscle satellite cells (MSCs). IGF-1R is an IGF-1 receptor with a transmembrane location that activates PI3K/Akt signaling and possesses tyrosine kinase activity, and its expression is significant in terms of myoblast proliferation and normal muscle mass maintenance. IGF-1 synthesis is elevated in MSCs of injured muscles and stimulates MSCs proliferation and myogenic differentiation. Mechanical loading also affects skeletal muscle production by IGF-1, and low IGF-1 levels are associated with low handgrip strength and poor physical performance. IGF-1 is potentially useful in the management of Duchenne muscular dystrophy, muscle atrophy, and promotes neurite development. This review highlights the role of IGF-1 in skeletal muscle, its importance during myogenesis, and its involvement in different disease conditions.

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“…The ECM of skeletal muscle maintains tissue integrity and provides structural support [ 1 , 2 ]. Generally, there are three layers of ECM in skeletal muscle: the endomysium, perimysium, and epimysium [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Aged Skeletal Muscle Retains the Ability to Remodel Extracellular Matrix for Degradation of Collagen Deposition after Muscle Injury

Chen

Lin

Lee

et al. 2021

IJMS

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Aging causes a decline in skeletal muscle function, resulting in a progressive loss of muscle mass, quality, and strength. A weak regenerative capacity is one of the critical causes of dysfunctional skeletal muscle in elderly individuals. The extracellular matrix (ECM) maintains the tissue framework structure in skeletal muscle. As shown by previous reports and our data, the gene expression of ECM components decreases with age, but the accumulation of collagen substantially increases in skeletal muscle. We examined the structural changes in ECM in aged skeletal muscle and found restricted ECM degradation. In aged skeletal muscles, several genes that maintain ECM structure, such as transforming growth factor β (TGF-β), tissue inhibitors of metalloproteinases (TIMPs), matrix metalloproteinases (MMPs), and cathepsins, were downregulated. Muscle injury can induce muscle repair and regeneration in young and adult skeletal muscles. Surprisingly, muscle injury could not only efficiently induce regeneration in aged skeletal muscle, but it could also activate ECM remodeling and the clearance of ECM deposition. These results will help elucidate the mechanisms of muscle fibrosis with age and develop innovative antifibrotic therapies to decrease excessive collagen deposition in aged muscle.

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Cross-Talk Between Extracellular Matrix and Skeletal Muscle: Implications for Myopathies

Cited by 45 publications

References 86 publications

Weighted gene co-expression network analysis identifies molecular pathways and hub genes involved in broiler White Striping and Wooden Breast myopathies

Weighted gene co-expression network analysis identifies molecular pathways and hub genes involved in broiler White Striping and Wooden Breast myopathies

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Aged Skeletal Muscle Retains the Ability to Remodel Extracellular Matrix for Degradation of Collagen Deposition after Muscle Injury

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